Recombinant Human IL-8
- Known as:
- Recombinant Human Interleukin-8
- Catalog number:
- SJB05-01
- Product Quantity:
- 25jg/vial
- Category:
- -
- Supplier:
- amoytop
- Gene target:
- Recombinant Human IL-8
Related genes to: Recombinant Human IL-8
- Gene:
- CXCL8 NIH gene
- Name:
- C-X-C motif chemokine ligand 8
- Previous symbol:
- IL8
- Synonyms:
- SCYB8, LUCT, LECT, MDNCF, TSG-1, IL-8, NAP-1, 3-10C, MONAP, AMCF-I, LYNAP, NAF, b-ENAP, GCP-1, K60, GCP1, NAP1
- Chromosome:
- 4q13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2016-10-05
- Gene:
- CXCR1 NIH gene
- Name:
- C-X-C motif chemokine receptor 1
- Previous symbol:
- CMKAR1, IL8RA
- Synonyms:
- CKR-1, CDw128a, CD181
- Chromosome:
- 2q35
- Locus Type:
- gene with protein product
- Date approved:
- 1992-11-09
- Date modifiied:
- 2016-03-14
- Gene:
- CXCR2 NIH gene
- Name:
- C-X-C motif chemokine receptor 2
- Previous symbol:
- IL8RB
- Synonyms:
- CMKAR2, CD182
- Chromosome:
- 2q35
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-19
- Date modifiied:
- 2016-03-14
- Gene:
- CXCR2P1 NIH gene
- Name:
- C-X-C motif chemokine receptor 2 pseudogene 1
- Previous symbol:
- IL8RBP, CXCR2P
- Synonyms:
- -
- Chromosome:
- 2q35
- Locus Type:
- pseudogene
- Date approved:
- 1992-11-27
- Date modifiied:
- 2016-03-14
Related products to: Recombinant Human IL-8
Related articles to: Recombinant Human IL-8
- Chronic obstructive pulmonary disease (COPD) is a leading global cause of mortality, with ambient fine particulate matter (PM) recognized as a key environmental risk factor. However, the circulating proteomic alterations that may underlie the association between long-term PM exposure and incident COPD remain incompletely characterized. - Source: PubMed
Publication date: 2026/06/08
Wang XiaojieShen YangLin ZihanZhuang ZitongYang ZijunZheng DashanLin Hualiang - Perchlorate, nitrate, and thiocyanate are thyroid disruptors. Emerging evidence suggests they may exert further effects independent of iodide uptake inhibition, influencing oxidative stress and thyroid tumour development. This study aimed to assess their effects on cell viability, proliferation, reactive oxygen species (ROS) production, and chemokine expression in normal human thyroid cells and thyroid cancer cell lines. - Source: PubMed
Publication date: 2026/05/22
Greco AlessiaCoperchini FrancescaFranchi ElenaDenegri MarcoCroce LauraTeliti MarsidaMarotta VincenzoMagri FlaviaDe Marco GiuseppinaFerrarini EleonoraPignata LuisaAgretti PatriziaTonacchera MassimoRotondi Mario - The bovine oviduct supports early reproductive events that require a balance between immune defense and tolerance. Glucocorticoids are well-known immune modulators; however, their presence, regulation, and functional relevance in the bovine oviduct remain poorly understood. This study investigated the presence and role of the corticosteroid system in the bovine oviduct and cultured bovine oviduct epithelial cells (BOECs). Bovine oviducts were collected during estrous cycle, fixed in 4% paraformaldehyde and processed for immunohistochemistry. BOECs were harvested from the ampulla and isthmus and cultured under sequential progesterone and estradiol treatment to mimic estrous cycles. On day 8, which equivalent to post‑ovulation day 1 in vivo, cells were treated with lipopolysaccharide (LPS; 1 μg/ml), cortisol (100 nM), cortisone (100 nM), or their combinations for 24 h. After culture, cells were harvested for gene analysis by RT-PCR, while spent media were collected for cortisol measurement by ELISA. Immunohistochemistry revealed predominant epithelial localization of NR3C1, NR3C2, HSD11B1, and HSD11B2 in both ampulla and isthmus. During 7-day preculture, expression of NR3C1 and HSD11B1 persisted, whereas that of NR3C2 and HSD11B2 declined sharply. LPS treatment on day 8 sharply upregulated TLR2, TNF, IL1B, IL6, CXCL8 and HSD11B1, whereas the concomitant treatment with cortisol suppressed all LPS-induced cytokines. BOECs were capable to convert added cortisone to cortisol, and LPS doubled this through up-regulating HSD11B1. Locally produced cortisol also suppressed LPS-induced cytokines. Collectively, these findings demonstrate that BOECs possess a functional glucocorticoid system, capable of producing cortisol from cortisone, which in turn suppresses LPS-induced inflammation. - Source: PubMed
Publication date: 2026/06/07
Ademola Omowumi FunmilayoPremaratne SameeraMuranishi YukiWatanabe HiroyukiTetsuka Masafumi - Hospitalization in older adults often leads to disability in daily living activities, thereby increasing the risk of functional and cognitive impairments. Thisrandomized controlled trial analyzed the serum protein profile of patients admitted to an acute geriatric unit who engaged in supervised multicomponent functional exercise program compared with a control group. Potential protein biomarkers were assessed using the Olink serum proteomics platform employing two predefined panels: Cardiometabolic and Inflammation. Notably, the short-term exercise intervention was associated with moderate but consistent changes in the serum proteome. Nominal differences (p < .05, unadjusted) were observed for amyloid beta precursor-like protein 1 (APLP1), complement C1q tumor necrosis factor-related protein 1 (C1QTNF1), interleukin-8 (CXCL8), interleukin-7 (IL-7), M-phase phosphoprotein 8 (MPHOSPH8), neurotrophin 3 (NTF3), tissue-type plasminogen activator (PLAT), SFRS1-interacting protein (PSIP1), pleiotrophin (PTN), cardiac-type troponin I (TNNI3), and von Willebrand factor (vWF); conversely, levels of CD40 ligand (CD40LG) were reduced. These findings suggest that short-term multicomponent functional exercise during acute hospitalization can induce changes in the serum proteome. These molecular alterations provide exploratory insights into the biological processes associated with the functional benefits observed following the intervention in hospitalized older adults. - Source: PubMed
Izco-Cubero MaiteLachén-Montes MercedesChenhuichen ChenhuiCedeno-Veloz Bernardo AbelEcheverría-Beistegui IcíarZambom-Ferraresi FabricioZambom-Ferraresi Fabiolade la Riva María Luisa Fernández-GonzálezÁlvarez-Rodríguez PatriciaSantamaría EnriqueMartínez-Velilla Nicolás - Despite a significant advance in multiple sclerosis (MS) treatment, the lack of reliable and easily available prognostic biomarkers, even with serum NfL and GFAP now available, is more exposed than ever, as they would enable tailoring the therapeutic approach to an individual. Since we earlier demonstrated a link between antinuclear antibodies (ANA) and soluble apoptotic factors sFas and sFasL, as well as between CXCL8 and CXCL10 chemokine levels and MS relapses, these analytes were deemed suitable for longitudinal assessment in this sense. - Source: PubMed
Publication date: 2026/06/01
Sremec JosipKošćak Lukač JelenaRaifi ZurapBačić Baronica KoraljkaTomić Sremec NadaRuška BerislavTomasović Sanja