Human cellexp IL-34, Human Recombinant proteins
- Known as:
- Human cellexp Interleukin-34, Human Recombinant proteins
- Catalog number:
- 7108-50
- Product Quantity:
- 50 μg
- Category:
- Proteins
- Supplier:
- Biovis
- Gene target:
- Human cellexp IL-34 Recombinant proteins
Related genes to: Human cellexp IL-34, Human Recombinant proteins
- Gene:
- IL34 NIH gene
- Name:
- interleukin 34
- Previous symbol:
- C16orf77
- Synonyms:
- MGC34647, IL-34
- Chromosome:
- 16q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2006-08-01
- Date modifiied:
- 2014-11-18
Related products to: Human cellexp IL-34, Human Recombinant proteins
Related articles to: Human cellexp IL-34, Human Recombinant proteins
- Cystic lesions are more prevalent in jawbones than in other bones. Odontogenic cysts are typically painless and asymptomatic and often reach significant sizes before detection. Unlike odontogenic cysts of inflammatory origin, understanding of the mechanisms of pathogenesis and progression of developmental odontogenic cysts remains incomplete. This study aimed to elucidate the cause and mechanisms of bone resorption in developmental odontogenic cysts. First, single-cell RNA sequencing was conducted for one of the most common developmental odontogenic cysts, dentigerous cysts, and the obtained data were compared with data of dental follicles of embedded teeth. Most differentially expressed genes in dentigerous cysts and dental follicles were associated with immunoglobulin secretion and an activated immunoglobulin-secreting plasma cell subtype was confirmed. Cell-to-cell interaction analysis revealed strong interactions between the activated plasma cells and leptin receptor-expressing (LepR) fibroblasts via "BMP6-BMPR2" interaction. These LepR fibroblasts constituted the majority of fibroblasts in dentigerous cysts. And these fibroblasts highly expressed genes related to osteoclastogenesis, such as CSF1, IL6, and IL34. Mouse bone marrow-derived monocytes and bone marrow mesenchymal stem cells were treated with culture supernatants of the LepR fibroblasts. The treatment led to osteoclast formation and bone resorption, and inhibition of BMP signaling suppressed the osteoclastogenesis effect. Thus, the LepR fibroblasts distinguished developmental odontogenic cysts from benign follicles; such cells interacted with activated plasma cell through the BMP signaling pathway. And the LepR fibroblasts were crucial in osteoclast induction and bone resorption in dentigerous cysts. This study confirmed a novel LepR fibroblast-induced bone erosion mechanism in developmental odontogenic cysts, which may inspire future pharmacological or surgical therapies. - Source: PubMed
Publication date: 2025/09/12
Bai HetianLi JinyongTu YetingBao Chongyun - This cohort study investigated salivary and serum chemerin, fetuin-A, interleukin (IL)-34, and IL-13 changes in type 2 diabetes mellitus (T2DM) periodontitis following non-surgical periodontal therapy (NSPT). - Source: PubMed
Publication date: 2025/09/11
Görgülü Nimet GülGüngörmek Hatice SelinKalkan YaprakDoğan Başak - The aquaculture industry has experienced considerable growth in recent decades, stimulating research into sustainable and functional feed formulations, mainly related to using high-quality, safe, and environmentally friendly feed ingredients. The employment of immunomodulatory additives is a promising strategy to enhance fish health and performance. In this study, the effects of the ghrelin analog GHRP-6 peptide included in the diet (500 µg/kg of feed) on the endocrine and immune responses of following Incomplete Freund's adjuvant (IFA) treatment were assessed. After 97 days, fish were intraperitoneally injected with 100 µL of saline solution or IFA/100 g fish and sampled 72 h post-injection. Our results indicated that fish fed GHRP-6 maintained stable plasma levels of lactate, triglycerides, and cortisol after IFA treatment, in contrast to control-fed fish, which showed significant metabolic stress. Circulating immunoglobulin levels enhanced significantly in the GHRP-6/IFA group, suggesting a stimulated humoral immune response. Transcriptomics analysis revealed that the anterior intestine was the most responsive tissue, with upregulation of , , , and , indicating mucosal immune activation. In the spleen, GHRP-6-fed fish increased , , and expression, highlighting a balanced pro- and anti-inflammatory response and support for adaptive immunity. Multivariate analysis confirmed that dietary GHRP-6 modulates immune gene expression in a tissue- and stimulus-specific manner, without inducing histological alterations in the intestine or spleen. Taken together, these preliminary results indicate that this peptide is a viable and safe dietary supplement to improve immune resilience and increase the production efficiency of and suggest a protective effect on the fish's immune system in this species. - Source: PubMed
Publication date: 2025/07/25
Rodríguez-Viera LeandroCaderno AnyellMartinez RebecaMartinez-Rodríguez GonzaloOliva MilagrosaPerera ErickMancera Juan MiguelMartos-Sitcha Juan Antonio - In 2021, the rapid rollout of two doses of SARS-CoV-2 vaccines reduced COVID-19 severity and mortality. However, further vaccine doses as a prime-boost schedule were limited, and lifting of public health restrictions by late 2021 frequently led to infection, rather than vaccine, as a third exposure. - Source: PubMed
Publication date: 2025/08/21
Ahimbisibwe GiftGreenwood DavidWilkinson Katalin AndreaGahir JoshuaTownsley HermaleighMiah MuradBawumia PhilipChaloner CharlotteLevi DinaHobson PhilipRiddell AndyHobbs AgnieszkaDowgier GiuliaPenn RebeccaSanderson TheoStevenson-Leggett PhoebeDaley OdiesiaBazire JamesHarvey RuthFowler Ashley SSmith CallieMiranda MauroO'Reilly NicolaWarchal ScottAmbrose KarenStrange AmyKelly GavinKjar Svend Williams BryanLibri VincenzoGamblin SteveGandhi SoniaSwanton CharlesBauer David LvWilkinson Robert JohnCarr Edward JWall Emma C - Immunosenescence, the age-related decline in immune function, profoundly impacts cancer progression and therapeutic outcomes by fostering a tumor-promoting microenvironment and impairing immune surveillance. This review delineates eleven molecular hallmarks of immunosenescence, including genomic instability, telomere attrition, epigenetic dysregulation, mitochondrial dysfunction, and chronic inflammation, which collectively drive immune cell dysfunction and systemic immunosuppression. Aging reshapes the tumor microenvironment (TME) through recruitment of immunosuppressive cells, senescence-associated secretory phenotypes (SASP), and metabolic reprogramming, contributing to therapy resistance and poor prognosis in elderly patients. While immunotherapies such as immune checkpoint inhibitors (ICIs) and chimeric antigen receptor T-cell immunotherapy (CAR-T) cells show promise, their efficacy in aging populations is limited by T cell exhaustion, myeloid bias, and altered intercellular communication. Emerging strategies-including senolytics, epigenetic modulators (e.g., histone deacetylase (HDAC) inhibitor), and metabolic interventions (e.g., spermidine, nicotinamide mononucleotide (NMN))-highlight potential avenues to rejuvenate aged immunity. Single-cell multi-omics (single cell RNA-seq, single cell ATAC-seq) further unravel immune cell heterogeneity, revealing tissue-specific chromatin accessibility dynamics and novel targets like interleukin-34 (IL-34) for microglia-mediated neuroinflammation. However, challenges persist in translating preclinical findings to clinical practice, necessitating age-tailored trials and biomarker-driven approaches. By integrating mechanistic insights with translational innovations, this review underscores the urgency of addressing immunosenescence to optimize cancer immunotherapy for aging populations, ultimately bridging the gap between aging biology and precision oncology. - Source: PubMed
Publication date: 2025/08/22
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