ANG-1, Human Recombinant proteins
- Known as:
- ANG-1, Human Recombinant proteins
- Catalog number:
- 7115-50
- Product Quantity:
- 50 μg
- Category:
- Proteins
- Supplier:
- Biovis
- Gene target:
- ANG-1 Human Recombinant proteins
Related genes to: ANG-1, Human Recombinant proteins
- Gene:
- TM7SF2 NIH gene
- Name:
- transmembrane 7 superfamily member 2
- Previous symbol:
- -
- Synonyms:
- ANG1, DHCR14A, NET47
- Chromosome:
- 11q13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1997-11-05
- Date modifiied:
- 2014-11-18
Related products to: ANG-1, Human Recombinant proteins
Related articles to: ANG-1, Human Recombinant proteins
- To advance the development of novel therapies for lung cancer, we investigated tumor-associated molecules implicated in tumorigenesis. RNA-seq data were generated from paired tumors and adjacent normal tissues of four patients with lung squamous cell carcinoma (LUSC) and five patients with lung adenocarcinoma (LUAD). Additional analyses utilized RNA-seq data from The Cancer Genome Atlas (TCGA), including paired tumor and adjacent normal samples (51 LUSC, 57 LUAD) and tumor-only samples (450 LUSC, 461 LUAD). Adjacent normal tissues served as controls. Our RNA-seq results showed strong concordance with TCGA data. Ion channels Aqp1, Aqp4, and Clic5 were significantly downregulated in lung tumors, whereas enzymes involved in membrane lipid metabolism, including phosphatidylcholine (PC), sphingomyelin (SM), and cholesterol (Cho), were upregulated in lung tumors. Cardiolipin (CL), a mitochondrial inner membrane lipid, was downregulated in lung tumors. These changes might have impaired oxygen permeability and mitochondrial function, promoting hypoxia and reactive oxygen species (ROS) production. Hif1α expression was elevated in both LUSC and LUAD, along with a hypoxiaresponsive protein kinase Csnk2a1 and its downstream targets Hdac1 and Hdac2. ROS-responsive transcription factors Yy1, Foxm1, E2f1, and E2f8 were also significantly upregulated in both LUSC and LUAD. Notably, the master epigenetic regulator Uhrf1 activated by these transcription factors showed marked overexpression in tumors compared to that in normal tissues. TCGA data corroborated these findings. Our study identified tumor cell membrane-associated molecules, including ion channels (Aqp1, Aqp4, Clic5) and membrane lipid metabolism enzymes (PC, SM, Cho, and CL), as critical contributors to lung tumorigenesis. These molecules represent promising targets for developing innovative anti-cancer therapies. - Source: PubMed
Publication date: 2025/09/16
Bae Heung-SeokCho Je-Yoel - The long non-coding RNA lnc-FANCI-2 acts as a host defense RNA and is highly expressed in HPV-positive cervical lesions. Its activation relies on the binding of the transcription factor YY1 to two conserved motifs in its promoter. We used DNA oligo pull-down combined with mass spectrometry to identify proteins binding to the lnc-FANCI-2 promoter, discovering new TFAP2 family members that compete with YY1 for binding at overlapping sites. In primary epithelial cells, TFAP2 binding led to lnc-FANCI-2 silencing. However, in HPV-positive cancer cells, increased YY1 levels displaced TFAP2, alleviating repression. Genome-wide predictions using the JASPAR database identified thousands of YY1 and TFAP2 competition binding sites (CBSs), many overlapping with CHIP-seq peaks for YY1, TFAP2A, and TFAP2C, predominantly in promoter regions. We validated competition at two CBSs in the promoter and found it likely regulates cancer-related genes PPP1R15B and LRRC37A. This suggests that YY1 and TFAP2 competition might influence a broader transcriptional regulation network in HPV-induced cancer. This study reveals a novel transcriptional antagonism mechanism affecting lnc-FANCI-2 and other cancer-related genes, highlighting YY1 and TFAP2 as potential therapeutic targets in HPV-driven carcinogenesis. - Source: PubMed
Publication date: 2025/09/15
Liu YiDing ShuangLiu Haibin - The mammalian genome is organized into large-scale chromosome territories, compartments, domains, and at the smallest scale, chromatin loops and stripes. The newest element is a chromatin jet, a diffused line perpendicular to the main diagonal in the Hi-C contact map, which was reported in quiescent mammalian lymphocytes supporting a two-sided symmetric cohesin loop extrusion model. A similar structure is observed in Repli-HiC data, where relatively thin and straight chromatin fountains indicate coupling of DNA replication forks. However, the precise biological implications of these jet-like structures are unknown due to the limitations in computational methods. We developed MIA-Jet, a multi-scale ridge detection algorithm that can accurately detect jets of variable lengths, widths, and angles. When tested on Hi-C, Repli-HiC, ChIA-PET, ChIA-Drop, and Micro-C data in mouse, human, roundworm, and zebrafish cells, MIA-Jet outperformed existing methods. In human cells, jets were enriched in cohesin loading sites and early replication initiation zones. Applying MIA-Jet to Hi-C data generated from protein-degraded cells revealed that jets are dependent on cohesin but not YY1, and jet signals are strengthened after depleting WAPL. We envision MIA-Jet to be broadly applicable to any 3D genome mapping data, thereby providing new insights into the functional roles of chromatin jets. - Source: PubMed
Publication date: 2025/09/01
Kim SionKim Minji - Diabetic hyperglycemia is often associated with elevated levels of trimethylamine-N-oxide (TMAO), a gut microbiota-derived metabolite that was recently identified as a risk factor for cardiovascular diseases. The combined presence of hyperglycemia and TMAO can aggravate cardiac dysfunction in diabetic patients. This study aimed to evaluate the protective effects of the methanolic extract of Syzygium aromaticum against the toxic effects induced by TMAO and hyperglycemia in cultured rat cardiomyocytes. - Source: PubMed
Publication date: 2025/09/10
Singhal ShivaniGupta JatinKushwaha Prem PrakashRani Vibha - Staphylococcus aureus is a major food-borne opportunistic pathogen that poses a significant public health threat, leading to severe tissue infections, bacteremia, and often life-threatening illness. While S. aureus has been extensively studied in livestock and poultry products in China, there is a notable lack of data regarding its presence and characteristics in aquatic products. This study investigates the prevalence, antibiotic resistance (ABR), its molecular profiling, and treatment regimens of S. aureus isolates from Oreochromis niloticus (Nile tilapia). A total of 300 tilapia samples from various fish markets showed an overall S. aureus prevalence of 31.67 %. ABR profiles revealed significant resistance to commonly used antibiotics, such as amoxicillin/clavulanic acid (65 %) and tetracycline (55 %), highlighting the widespread emergence of resistance. Phylogenetic analysis revealed strong clade support for resistance gene clusters, such as MecA/C, ErmA, and TetK. Motif analysis showed distinct motifs, indicating their role in ABR mechanisms. Physiochemical properties showed that β-lactams and macrolides have a hydrophilic nature, and the tetracycline class exhibited a hydrophobic nature. BlaZ and MecA exhibit the highest occurrence of GATA, potentially emphasizing the regulation by transcription factors in the resistance to β-lactams group, while TEM exhibited a high frequency of GATA, YY1, and OCT1, implying these factors may regulate β-lactamase production. Through synergy evolution, one synergistic and three additive interactions were identified, indicating its potential for novel combination therapies against multidrug-resistant (MDR) pathogens. Our study findings underscore the severity of ABR in aquaculture, highlighting the importance of effective antibiotic strategies. The comparative analysis of treatment efficacy also highlights the need for alternative strategies to control bacterial infections. Overall, our work offers valuable insights into resistance mechanisms and future management approaches for combating MDR pathogens in aquaculture settings. - Source: PubMed
Publication date: 2025/09/11
Shafique LaibaZhu PengXu YouhouHassan WardahLatif FarihaManan Muhammad AbdulParveen ShakeelaKhan Muhammad Farhan