Recombinant Human STAT5B
- Known as:
- Recombinant Human STAT5B
- Catalog number:
- CG38
- Product Quantity:
- 10ug
- Category:
- -
- Supplier:
- Novoprotein
- Gene target:
- Recombinant Human STAT5B
Related genes to: Recombinant Human STAT5B
- Gene:
- STAT5B NIH gene
- Name:
- signal transducer and activator of transcription 5B
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 17q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1997-01-28
- Date modifiied:
- 2019-04-23
Related products to: Recombinant Human STAT5B
Related articles to: Recombinant Human STAT5B
- Mutations in cytokine receptor and JAK/STAT; Cy-JAK/STAT) signaling genes drive myeloproliferative neoplasms (MPNs) but remain incompletely characterized in acute myeloid leukemia (AML). The authors evaluated the prevalence, clinical presentation, and prognostic significance of Cy-JAK/STAT pathway mutations in patients with AML and compared outcomes across disease ontogeny. - Source: PubMed
Albliwi MoathNurse Daniel PZabor Emily CHanna JohnEl-Asmar JessicaBawwab AmeedAbuamsha HasanAbu-Farsakh YomnaBatah HeyaRauf AsadNakitandwe JoyBosler David SParthasarathy Prerana BangaloreAlban TylerJain Akriti GMolina John CBalderman SophiaSingh AbhayGerds Aaron TMukherjee SudiptoAdvani Anjali SCarraway Hetty EMustafa Ali Moaath K - Interferon regulatory factors (IRFs) are innate immune transcription factors responsible for inducing the expression of type I interferons (IFN-I), which combat pathogen invasions via initiating the downstream Janus kinase signal transducer and activator of transcription (JAK-STAT) pathway. Among them, IRF7 plays a central role by forming heterodimers with IRF3 to initiate IFN-I production and is therefore frequently targeted by viruses to evade immune detection. Contrary to this common paradigm, we show that IRF7 is activated and upregulated by the retrovirus human T-cell leukemia virus type 1 (HTLV-1), via its oncoprotein HBZ. Moreover, IRF7 is highly expressed in HTLV-1 induced CD4 T-cell malignancy named adult T-cell leukemia/lymphoma (ATLL), and promotes the proliferation of infected cells both in vitro and in vivo. Intriguingly, HBZ is able to interfere with the interaction of IRF7 and IRF3, suppressing IFN-I pathway activation. On the other hand, IRF7 was found to upregulate and activate STAT5B, a transcription factor of the JAK-STAT pathway frequently mutated in hematological malignancies. Together, these findings reveal a mechanism by which HTLV-1 hijacks a critical innate immune effector to sustain persistent infection and drive oncogenesis without activating antiviral IFN-I pathway. - Source: PubMed
Publication date: 2026/05/11
Yuan XiaoyiYue YunyunChen LiangLiu DongmeiLiang YiLu ChengchengYang SikaiHe ZengFan ChunxinShang JingMatsuoka MasaoMa Guangyong - In flatfish aquaculture, labour-intensive tank cleaning represents a major operational challenge, limiting sustainability due to its high labour requirements and associated costs. We tested a new semi-closed recirculating aquaculture system (RAS) protocol for (tongue sole), replacing manual cleaning with post-feeding water exchange (80% drained) and probiotic application. Compared with control groups, the probiotic-water exchange protocol significantly improved growth (+0.18%/day) and survival (+7.9%), while shifting the gut microbiota from a -dominated configuration to a -dominated one. Metagenomics revealed that became the predominant taxon (86%) in the probiotic group, accompanied by the enrichment of quorum sensing pathways, CAZymes (CEs, AAs), and nutrient metabolism functions. Histological examination showed improvements in the intestinal muscular layer and villi structure. Multi-tissue transcriptomics identified systemic changes in immune and metabolic pathways, including activation of intestinal immune networks (IgA production, NF-κB signaling) and antimicrobial peptide genes. Liver, gill, and skin transcriptomes revealed enhanced DNA repair, cytokine signaling, and barrier pathways. JAK-STAT pathway was also activated, linking microbial metabolite sensing to growth promotion (). The probiotic-integrated protocol modifies the gut microbiome by shifting microbial composition through changes in competitive interactions and microbial signaling pathways. It also improves the intestinal wall, overall immunity, and nutrient absorption. These findings provide insights into the microbiome-host interaction under probiotic treatment and suggest that this strategy may offer potential benefits under farm conditions, but further studies are needed to validate its safety and ecological implications. - Source: PubMed
Publication date: 2026/04/23
Hu YuanriYan XuGao FengtaoXu DanYang YingmingCheng JiayuChen SonglinCui Zhongkai - Not available. - Source: PubMed
Publication date: 2026/05/07
Su ZhanFeng Xianqi - - Source: PubMed
Publication date: 2026/05/05
Turingan Mark AnthonyWei CuihongAlmokhtar NihadVijenthira AbiChang Hong