Human Angiopoietin Like Protein 4 ELISA , ANGPTL4
- Known as:
- Human Angiopoietin Like Protein 4 Enzyme-linked immunosorbent assay test , ANGPTL4
- Catalog number:
- E01A0507
- Product Quantity:
- 96 Tests/kit
- Category:
- -
- Supplier:
- BGene
- Gene target:
- Human Angiopoietin Like Protein 4 ELISA ANGPTL4
Related genes to: Human Angiopoietin Like Protein 4 ELISA , ANGPTL4
- Gene:
- ANGPTL4 NIH gene
- Name:
- angiopoietin like 4
- Previous symbol:
- -
- Synonyms:
- pp1158, PGAR, ARP4, HFARP, FIAF, NL2
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-07-18
- Date modifiied:
- 2016-10-04
Related products to: Human Angiopoietin Like Protein 4 ELISA , ANGPTL4
Related articles to: Human Angiopoietin Like Protein 4 ELISA , ANGPTL4
- Indonesian sheep, shaped by survival, reproduction and productivity in humid tropical climates, may carry genomic regions associated with local adaptation and economically important traits that remain largely unexplored. This study performed genetic diversity analysis on 17,534 SNPs derived from the OvineSNP50 BeadChip genotyping array, involving 120 individuals among five local Indonesian sheep breeds: Batur, Garut, Sakub, Sumatra and Thin-tail. Analysis of genetic structure, incorporating PCA, maximum-likelihood phylogenetics analysis and Admixture analyses, demonstrated that each population displayed a uniquely homogeneous and distinctive ancestry profile, with the exception of Sakub and Thin-tail. Additionally, a close genetic relationship among Sakub, Garut and Thin-tail sheep was identified. We employed four complementary approaches of within and cross population selection signature analyses to identify putative selection signatures within 13 genomic regions. Several genes identified within the selection signature regions are potentially associated with the immune system (e.g., , and ), wool traits and pigmentation (e.g., and ), reproductive traits (e.g., and ), milk traits (e.g., and ), meat traits (e.g., and ), and adaptive traits (e.g., and ). Understanding the candidate genomic areas under selective pressure in sheep breeds may aid in identifying the associated genes and improve our comprehension of their involvement in local adaptation. Consequently, this research provides a preliminary genomic resource for the conservation and utilization of these sheep genetic resources in Indonesia. - Source: PubMed
Publication date: 2026/06/01
Astuti Putri KusumaMizeranschi Alexandru EugeniuHerdis HerdisSitaresmi Pradita IustitiaIbrahim AlekPrastowo SigitWidyas NuzulNugroho TristiantoKusza Szilvia - Type 1 diabetes and type 2 diabetes are associated with an increased risk of atherosclerotic cardiovascular disease (ASCVD), manifested as myocardial infarction, ischemic stroke, and peripheral artery disease. The increased ASCVD risk in diabetes cannot be fully explained by traditional risk factors. This review highlights the dysregulation of TRLs (triglyceride-rich lipoproteins; VLDL [very low-density lipoprotein] and chylomicrons), and their remnants, as contributors to ASCVD risk in diabetes by examining 6 typical clinical cases integrated with mechanistic data obtained in preclinical models. Type 2 diabetes is often associated with insulin resistance and increased hepatic secretion of VLDL particles, which are enlarged by an increased lipid load, increased intestinal secretion of chylomicrons, and reduced hepatic clearance of both VLDL and chylomicron remnants. The increased levels of TRLs in turn contribute to the predominance of smaller, denser LDL (low-density lipoprotein) particles and smaller cholesterol-depleted HDL (high-density lipoprotein) particles compared with people without diabetes. When type 2 diabetes occurs in individuals with genetic variants causing altered function of proteins stimulating TRL clearance (, or ) or suppressing TRL clearance (), the result is a compounded accumulation of TRLs and their remnants in plasma and an associated increased ASCVD risk. VLDL secretion is usually unaltered in individuals with well-controlled type 1 diabetes, but ASCVD risk is increased when insulin resistance and defects in TRL clearance are also present. Mechanistically, TRLs enhance ASCVD risk at least in part by exacerbating local vascular inflammation caused by the accumulation of free cholesterol and triglyceride lipolysis products. Because cardiovascular outcome trials targeting triglyceride levels to date have been mostly futile, the field is now focused on trials targeting proteins involved in TRL clearance. Carefully determining inclusion and exclusion criteria for such trials will be critical for advancing our understanding of how to better prevent ASCVD in individuals living with diabetes. - Source: PubMed
Publication date: 2026/06/04
Ginsberg Henry NBornfeldt Karin E - Neonatal respiratory distress syndrome (NRDS), resulting from pulmonary surfactant deficiency, continues to be a significant cause of morbidity and mortality in preterm infants. Conventional diagnostic and therapeutic approaches have notable limitations in early warning and prognostic stratification. Consequently, biomarker research has emerged as a promising new direction in this field. We systematically searched PubMed, Web of Science, and Embase for studies published from January 2010 to December 2025, focusing on those that evaluated the application of inflammatory markers, microRNAs, protein and peptide biomarkers, and lung ultrasound score (LUS) in NRDS. The main findings were as follows: ① inflammatory biomarkers: IL-6, IL-17, and related markers were positively associated with disease severity, although their specificity remained limited; IL-37 showed potential as an anti-inflammatory therapeutic target. ② microRNAs: miR-375, miR-363, and others show better performance when combined with lung ultrasound and blood gas parameters, but this is based on preliminary single-center data. ③ Protein biomarkers: ANGPTL4 has diagnostic and prognostic value; combining it with lung ultrasound increases AUC, but evidence is still early and lacks external validation. ④ Clinical tools: Lung ultrasound, as a non-invasive real-time bedside tool, has good diagnostic performance and is convenient for repeated exams, but its combined use with emerging molecular markers requires further study. ⑤ Machine learning: although it has shown advantages in multimodal data integration, most models still lack external validation, and concerns regarding overfitting and limited interpretability continue to restrict clinical implementation. Overall, combined biomarker strategies and tools like lung ultrasound have shown promise in some studies, but current evidence is insufficient for broader clinical use. Most emerging biomarkers, including miRNAs and peptide markers, face challenges with assay standardization, independent validation, and prospective evaluation. Future studies should aim to translate biomarkers from laboratory discoveries to bedside applications while enhancing the robustness and interpretability of machine learning models. - Source: PubMed
Publication date: 2026/05/18
Xiong MaoTingDeng JiaHongZhao Jing - Intrahepatic metastasis (IM) is a critical predictor of poor prognosis in intrahepatic cholangiocarcinoma (iCCA), yet the tumor microenvironmental mechanisms driving this process remain poorly understood. By integrating single-cell RNA sequencing data from 15 iCCA samples with a public transcriptomic cohort of 255 patients (OEP001105), we characterized the immune and malignant epithelial landscapes associated with IM. We identified ANGPTL4-positive tumor-associated macrophages and hypoxia-associated malignant epithelial cells that were enriched in the IM group. Mechanistically, hypoxia induced the transcription factor CEBPB in macrophages, which directly activated ANGPTL4 transcription. Macrophage-derived ANGPTL4 subsequently engaged Integrin α5β1 on iCCA cells, activating the FAK/Src/GSK3β/β-catenin signaling cascade, promoting β-catenin nuclear translocation, and inducing epithelial-mesenchymal transition-associated remodeling. Functional assays and in vivo metastasis models demonstrated that ANGPTL4 enhanced iCCA cell migration, invasion, and liver metastasis, whereas ANGPTL4 blockade attenuated these effects. Clinical validation using ELISA and multiplex immunofluorescence further showed that elevated serum and tissue ANGPTL4 levels were associated with tumor burden and IM. Collectively, our study reveals a hypoxia-driven tumor microenvironmental communication axis between tumor-associated macrophages and malignant epithelial cells, highlighting ANGPTL4 as a potential non-invasive serum biomarker and therapeutic target for iCCA intrahepatic metastasis. - Source: PubMed
Publication date: 2026/05/28
Lin ZhuHua HongpengHuang YanLi XingyuLiang YonglingYi TaijunJin HuilinWu JiayanWan YunleLi Guolin - Childhood obesity is rising globally. Yet, few studies have examined the microbiome and proteome in early childhood in relation to this outcome, and most are cross-sectional by design. Early-life factors in the ABIS birth cohort ( = 16,683) were associated with obesity up to age 26 (mean follow-up 25.3 years, range 23.7-26.5 years): psychosocial stressors, smoking, infections, and diet in the first year. We assessed biomarkers, including cord blood metabolome ( = 290) and proteome ( = 358), by liquid chromatography, mass spectrometry, and Olink. Gut microbial composition at age one ( = 1,743) was assessed using stool samples and 16S rRNA sequencing. In this prospective longitudinal cohort study, significant differences were found in infants with future obesity, including elevated angiopoietin-like 4 (ANGPTL4), follistatin, and hepatocyte growth factor (independently of maternal weight) and reduced isocaproic acid, tryptophan, and oleic acid, with prenatal mediation. , asaccharolytic bacteria ( and ), and equol-producers ( and ) were depleted. Machine learning models selecting 40 most predictive features showed long-term prediction from birth proteomics and bacterial taxa at age one (area under the curve [AUC] = 0.83 ± .05, = 1,877) and additional metrics, for example, parental and child body mass index in the first 8 years (AUC = 0.89 ± .02, = 1,877), suggesting durable biological encoding. Proteomic markers across folds included fibroblast growth factor 19, ANGPTL4, sulfotransferase family 2A member 1, and interleukin 20. These findings suggest clinically relevant biomarkers indicating early-life regulation of bile acid metabolism, lipid storage vs. oxidation, and immune-metabolic signaling and pathways to prospectively prevent childhood- and adult-onset obesity across a 26-year predictive gap. - Source: PubMed
Publication date: 2026/05/28
Ahrens Angelica PDias RaquelHyötyläinen TuuliaWhite Pär AndersonOrešič MatejTriplett Eric WLudvigsson Johnny