TACS 2 TdT_DAB Kit
- Known as:
- TACS 2 TdT_DAB Kit
- Catalog number:
- 4810-30-K
- Product Quantity:
- 30 Samples
- Category:
- -
- Supplier:
- Trevigen
- Gene target:
- TACS 2 TdT_DAB Kit
Related genes to: TACS 2 TdT_DAB Kit
- Gene:
- EPCAM NIH gene
- Name:
- epithelial cell adhesion molecule
- Previous symbol:
- M4S1, MIC18, TACSTD1
- Synonyms:
- Ly74, TROP1, GA733-2, EGP34, EGP40, EGP-2, KSA, CD326, Ep-CAM, HEA125, KS1/4, MK-1, MH99, MOC31, 323/A3, 17-1A, TACST-1, CO-17A, ESA
- Chromosome:
- 2p21
- Locus Type:
- gene with protein product
- Date approved:
- 1995-10-02
- Date modifiied:
- 2019-04-23
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- Bladder cancer, the most common malignancy of the urinary system, is associated with poor prognosis due to its metastatic potential, invasive behavior, and immune evasion. Intercellular adhesion molecule 5 (ICAM5), a member of the immunoglobulin superfamily, regulates cell adhesion and has been implicated in tumor progression. However, its biological function in bladder cancer remains unclear. - Source: PubMed
Publication date: 2026/06/08
Chen XiaolongWang ZhenRong YangshengZhu ZhiqiangPeng ZhengHuang KunyuanDeng GuanyunLiu DiWang QingZhu JianguoChen KunJiang Kehua - The global incidence of hepatocellular carcinoma (HCC) is rising steadily, yet early detection methods remain a major clinical challenge due to genetic heterogeneity and variable target expression in these tumors. Conventional imaging approaches rely on non-specific or single targets, and often fail to achieve sufficient sensitivity or specificity, in particular, for early stage disease. A peptide multimer capable of simultaneously targeting 3 early HCC targets, including GPC3, CD44, and EpCAM, using a single biochemical construct was demonstrated. The multimer was labeled with either Cy5.5 for fluorescence imaging or Gd-DOTA for MRI to enable dual-modality detection. In vitro analysis using patient-derived HCC cell lines and organoids, and demonstrated significantly enhanced binding kinetics and affinity, including a 2.6-fold increase in fluorescence intensity and a 2.18-fold faster association rate compared with individual monomers. In vivo MRI in orthotopic patient-derived xenograft (PDX) models, both with and without cirrhosis, showed a peak tumor-to-background ratio of 3.05 at 0.5 hours post-injection and rapid renal clearance by about 4 hours. Ex vivo immunofluorescence of human liver specimens yielded 87% sensitivity and 80% specificity for distinguishing HCC from cirrhosis. These findings highlight multimer potential as a clinically translatable platform to improve early HCC diagnosis via enhanced molecular imaging. - Source: PubMed
Publication date: 2025/07/25
Feng ShuoWu XiaoliChoi Eun-Young KChang Tse-ShaoZhang RuoliuJaiswal SangeetaDuan YutingJiang HuiWang Thomas D - Congenital tufting enteropathy (CTE) is a rare autosomal-recessive enteropathy caused by variants. While the clinical spectrum ranges from intractable diarrhea to manageable outcomes, the genotype-phenotype correlation remains undefined. - Source: PubMed
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Zhao LiqianZheng YucanLiu HaoLiu ZhifengLu YanYan Kunlong - Ewing sarcoma (EWS) is a highly aggressive and poorly differentiated malignancy. Despite its high metastatic potential, the molecular mechanisms underlying EWS metastasis remain largely unclear. - Source: PubMed
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Deng BinYao ShengchengSun ShaosongZhang XingchenGuo Kaijin - Penile squamous cell carcinoma (PSCC) can affect men of any age, but we know little about the differences between non-old and old patients with PSCC, which severely limits the precise diagnosis and treatment of PSCC. - Source: PubMed
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