STOM antibody (clone AT33F5)
- Known as:
- STOM (anti-) (clonality AT33F5)
- Catalog number:
- ATGA0291
- Product Quantity:
- 100ul
- Category:
- -
- Supplier:
- ATGen
- Gene target:
- STOM antibody (clone AT33F5)
Related genes to: STOM antibody (clone AT33F5)
- Gene:
- STOM NIH gene
- Name:
- stomatin
- Previous symbol:
- EPB7, EPB72
- Synonyms:
- BND7
- Chromosome:
- 9q33.2
- Locus Type:
- gene with protein product
- Date approved:
- 1992-09-14
- Date modifiied:
- 2016-10-05
Related products to: STOM antibody (clone AT33F5)
Related articles to: STOM antibody (clone AT33F5)
- Inflammation-induced pulmonary fibrosis is an irreversible and severe complication that leads to persistent decline in lung function and increased mortality; however, its early pathogenesis is still unclear. This study aimed to systematically elucidate the initiation mechanism of pulmonary fibrosis in the early stages of inflammation. By integrating multi-omics data and animal models, we found that lung exhibits stronger immune amplification and more severe mitochondrial dysfunction in comparison with other organs during inflammation, consequently fibrotic signaling is initiated in the acute phase. Mitochondria-related gene analysis identified six key genes (Bcl2l1, Gsr, Msrb3, AA467197, Stom, and Sod2) involved in the regulation of reactive oxygen species (ROS) metabolism, which were closely associated with clinical outcomes in sepsis. Temporal data and TNF-α/IL-1β intervention experiments revealed that these cytokines are persistently overexpressed in septic lungs, serving as critical drivers of ROS activation. In vitro assays further confirmed that ROS overload directly induces cellular damage and functional reprogramming of fibroblasts. Through bulk and single-cell transcriptomic analyses, we elucidated the alteration of intercellular communication between immune and parenchymal cells, and identified Col13a1 fibroblasts as a key subpopulation with the capability to drive fibrotic remodeling. In conclusion, sustained TNF-α/IL-1β signaling in septic lungs exacerbates ROS accumulation, thereby driving aberrant fibroblast repair and initiating pulmonary fibrosis, in which Col13a1 fibroblasts represent the major profibrotic subpopulation. Thus, the early inhibition of TNF-α/IL-1β expression, suppression of ROS accumulation, and regulation of Col13a1 fibroblast activation may provide an effective therapeutic strategy for sepsis. - Source: PubMed
Publication date: 2026/05/16
Zhong ZhaoqianWu KanWang JunhaoChen GuimingLuo HaihuaChen GuangqinSun ChangGuo DanyanLi LeyiLi LeiJiang Yong - The sorption of cells of an electrogenic strain of microorganisms 1-i onto the surface of carbon fabric polarized by applying a voltage of 1 V was studied. In the absence of voltage, the sorption of cells on the carbon fabric was observed to be 36.5%. The sorption of cells, pre-killed by heating under similar conditions, was notably lower, at 26.5%. This value remained almost the same when the voltage was increased to 1 V. Therefore, the specified voltage value had no adverse effect on the adhesion processes of microbial cells on the electrode surface. The determination of microbial cell viability was carried out using luminescence microscopy, a Luna-II YF cell counter, and double staining of cells with fluorescent dyes, specifically acridine orange and propidium iodide. The viability of microorganisms sorbed on carbon fabric at a voltage of 1 V was maintained at a level comparable to that of the control (0 V). Furthermore, the viability of the bacterial suspension remained the same following contact with the polarized electrodes (1 V). It was demonstrated that the voltage generated in a microbial fuel cell (MFC) exhibited no detrimental impact on the viability of strain cells, whether suspended in the interelectrode space or adsorbed onto the electrodes. Furthermore, the investigated microorganisms remained viable across a broad pH range of the medium, from 4.0 to 12.0. The obtained results illustrate the remarkable resilience of the 1-i bacterial strain to the harsh environmental conditions that are inherent to the functioning of MFCs. - Source: PubMed
Publication date: 2025/05/09
Saksonov Michael NStom Devard IKhramtsova Ksenia AZhdanova Galina OKupchinsky Aleksander BAlferov Sergey VZhou QixingBarbora Lepakshi - Stomatin is a ubiquitous and highly expressed protein in erythrocytes, which associates with cholesterol-rich microdomains in the plasma membrane and is known to regulate the activity of multiple ion channels and transporters, but the structural basis of association with stomatin targets remains unknown. Here, we describe high-resolution structures of multiple stomatin complexes with endogenous binding partners isolated from human erythrocyte membranes, revealing that stomatin specifically associates with two membrane proteins involved in water transport and cell volume regulation, aquaporin-1 and the urea transporter SLC14A1. Together, our results reveal the structural basis of stomatin oligomerization, membrane association, and target recruitment and identify a putative role for stomatin in the regulation of osmotic balance in the erythrocyte. - Source: PubMed
Publication date: 2026/04/01
Vallese FrancescaLi HuanBarazzuol LuciaCalì TitoClarke Oliver B - Maxillary sinus floor elevation is a well-established procedure for increasing bone volume in the posterior maxilla, yet the regenerative outcome depends strongly on the choice of grafting material. This clinical study compared a high-temperature sintered xenograft (Bio-Oss) and a low-temperature processed xenograft (Ti-Oss) with regard to their regenerative and immunological profiles. - Source: PubMed
Korzinskas TadasSchnettler ReinerRimashevskiy DenisMalik BirzhanDakenov BaurzhanBagdoniene DianaJung OleBarbeck Mike - Plant-microbe interactions regulate soil greenhouse gas (GHGs) fluxes, yet their responses to climate extremes remains unclear. In a factorial experiment combining plant composition (bare soil, monoculture, intercropping) with contrasting temperatures, we found that the soil global warming potential (GWP) mitigation effect of intercropping under extreme high temperature (EHT) significantly declined by 17.4 % compared with normal temperature (LT). EHT suppressed plant biomass (-41.9 % to -86.6 %), diminished soil carbon sequestration (-0.9 % to -6.9 %), and increased the r/K strategy ratios (+0.7 % to +5.7 %). It further erased the clear separation between intercropping and monoculture microbial communities evident under LT and upregulated key N-loss genes (e.g., nirS, norC), jointly undermining the microbial basis of plant-mediated GHGs mitigation. Our findings highlight that while plant diversity stabilizes soil biogeochemistry and constrains GHGs release, its buffering efficacy is inherently fragile under EHT, providing new evidence of limits to biotic regulation in a warming world. - Source: PubMed
Publication date: 2025/12/16
Zhang XiangWei LimanYang ChangmingZhao QiongStom Devard ILi TianZhou Qixing