DAPK2 / DRP-1 antibody Host Rabbit
- Known as:
- DAPK2 / DRP-1 (anti-) Host Rabbit
- Catalog number:
- 'AP07740PU-N
- Product Quantity:
- 50
- Category:
- -
- Supplier:
- ACR
- Gene target:
- DAPK2 / DRP-1 antibody Host Rabbit
Related genes to: DAPK2 / DRP-1 antibody Host Rabbit
- Gene:
- DAPK2 NIH gene
- Name:
- death associated protein kinase 2
- Previous symbol:
- -
- Synonyms:
- DRP-1, MGC119312
- Chromosome:
- 15q22.31
- Locus Type:
- gene with protein product
- Date approved:
- 1999-10-19
- Date modifiied:
- 2016-10-05
- Gene:
- DENR NIH gene
- Name:
- density regulated re-initiation and release factor
- Previous symbol:
- -
- Synonyms:
- DRP, DRP1, SMAP-3
- Chromosome:
- 12q24.31
- Locus Type:
- gene with protein product
- Date approved:
- 1999-06-17
- Date modifiied:
- 2016-07-04
- Gene:
- DNM1L NIH gene
- Name:
- dynamin 1 like
- Previous symbol:
- -
- Synonyms:
- DRP1, DVLP, HDYNIV, DYMPLE, VPS1
- Chromosome:
- 12p11.21
- Locus Type:
- gene with protein product
- Date approved:
- 2000-04-12
- Date modifiied:
- 2016-07-05
- Gene:
- TDRP NIH gene
- Name:
- testis development related protein
- Previous symbol:
- C8orf42
- Synonyms:
- INM01, TDRP1, TDRP2
- Chromosome:
- 8p23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-07-28
- Date modifiied:
- 2015-08-26
- Gene:
- UBQLN1 NIH gene
- Name:
- ubiquilin 1
- Previous symbol:
- -
- Synonyms:
- DSK2, PLIC-1, XDRP1, DA41
- Chromosome:
- 9q21.32
- Locus Type:
- gene with protein product
- Date approved:
- 2000-02-18
- Date modifiied:
- 2016-10-05
Related products to: DAPK2 / DRP-1 antibody Host Rabbit
Related articles to: DAPK2 / DRP-1 antibody Host Rabbit
- Death-associated protein kinase (DAPk) and DAPk-related protein kinase (DRP)-1 proteins are Ca+2/calmodulin-regulated Ser/Thr death kinases whose precise roles in programmed cell death are still mostly unknown. In this study, we dissected the subcellular events in which these kinases are involved during cell death. Expression of each of these DAPk subfamily members in their activated forms triggered two major cytoplasmic events: membrane blebbing, characteristic of several types of cell death, and extensive autophagy, which is typical of autophagic (type II) programmed cell death. These two different cellular outcomes were totally independent of caspase activity. It was also found that dominant negative mutants of DAPk or DRP-1 reduced membrane blebbing during the p55/tumor necrosis factor receptor 1-induced type I apoptosis but did not prevent nuclear fragmentation. In addition, expression of the dominant negative mutant of DRP-1 or of DAPk antisense mRNA reduced autophagy induced by antiestrogens, amino acid starvation, or administration of interferon-gamma. Thus, both endogenous DAPk and DRP-1 possess rate-limiting functions in these two distinct cytoplasmic events. Finally, immunogold staining showed that DRP-1 is localized inside the autophagic vesicles, suggesting a direct involvement of this kinase in the process of autophagy. - Source: PubMed
Publication date: 2002/04/29
Inbal BoazBialik ShaniSabanay IlanaShani GidiKimchi Adi