C_REACTIVE PROTEIN, Canine
- Known as:
- C_REACTIVE PROTEIN, Canine
- Catalog number:
- 143-10
- Product Quantity:
- 100 ug
- Category:
- -
- Supplier:
- LeeBio
- Gene target:
- C_REACTIVE PROTEIN Canine
Related genes to: C_REACTIVE PROTEIN, Canine
- Gene:
- TYRP1 NIH gene
- Name:
- tyrosinase related protein 1
- Previous symbol:
- TYRP, CAS2
- Synonyms:
- GP75, CATB, TRP, b-PROTEIN, OCA3
- Chromosome:
- 9p23
- Locus Type:
- gene with protein product
- Date approved:
- 1991-09-04
- Date modifiied:
- 2016-04-19
Related products to: C_REACTIVE PROTEIN, Canine
Related articles to: C_REACTIVE PROTEIN, Canine
- Although PD-1 inhibitors have significantly reduced metastatic melanoma patients' mortality, only a small proportion of these patients actually benefit. We aim to develop some parsimonious predictive models for identifying those patients' survival outcome under anti-PD-1 treatment. - Source: PubMed
Publication date: 2026/05/18
Wang YuTang WeiWang YuanyuanLu XiaoyuZhang LingYang JiaojiaoYang ShuibingYang Jingjin - In the cosmetic industry, active ingredients often consist of organic compounds that are hydrophobic, making oil-based formulations impractical. Oil-in-water (O/W) nanoemulsions are used to deliver such ingredients in an aqueous medium. However, creating stable nanoemulsions with uniform size, especially from natural products, poses significant challenges. This study presents the development of micellar O/W nanoemulsions to deliver meroterpenoid-rich fractions from the ethanolic extract of (MES). We systematically investigated the effects of mixing order and chemical compositions on the size and stability of nanoemulsions, enhancing stability with a tri-block copolymer for micellar features. Under optimised conditions, nanoemulsions with a size around 20 nm were prepared. The MES-loaded nanoemulsion effectively inhibited melanin production over multiple cycles, demonstrating increased stability against oxidation. Molecular docking revealed strong binding affinities of MES compounds to tyrosinase-related protein 1 (TYRP1), indicating potential as effective skin-whitening agents. - Source: PubMed
Publication date: 2024/12/30
Siboro Sonita A PSalma Sabrina AufarYuliati FritaRahayu Iresha MuthiaTaek Lim Kwon - Excessive melanin accumulation causes hyperpigmentation, a skin pathophysiology that highlights the need for safe and multifunctional skin-whitening agents. Building on the reported tyrosinase inhibitory potential of phenylthiazole derivatives, a series of compounds was designed and synthesized to investigate the structural determinants of their multi-functional activities. The biological evaluation included mushroom tyrosinase (mTYR) inhibition, as well as anti-melanogenic, anti-inflammatory, and antioxidant assays. Among the series, compound 3c exhibited the most potent multi-functional profile, showing mTYR inhibition (IC = 30.8 ± 2.7 µM) with a mixed-type inhibitory mechanism (K = 20 µM), a 34% reduction in melanin content at 40 µM, significant nitric oxide inhibition (IC = 33.7 ± 2.0 µM), and strong antioxidant activity (SC = 29.0 ± 0.8 µM). Density Functional Theory (DFT) calculations and predicted physicochemical properties indicate that 3c possesses favorable molecular stability and promising potential for skin penetration. Molecular docking and molecular dynamics (MD) simulations further demonstrated that 3c stably occupies the active pocket of human tyrosinase-related protein 1 (TYRP1, PDB ID: 5M8M), forming key interactions with Zn-coordinating residues and maintaining a stable energetic profile. Collectively, these findings indicate that 3c exhibits the most balanced multi-functional activity within the series and holds promise as a lead compound for topical skin-whitening applications. - Source: PubMed
Publication date: 2026/05/12
Xu YangLiang XuhuiHyun Chang-Gu - The Taiwanese loach (Paramisgurnus dabryanus ssp. Taiwanese), known for its nutritional and ornamental qualities, exhibits a rare form of albinism. Specifically, certain individuals display golden-pink eyes and a golden-red body color devoid of blotches, thereby attracting consumers. However, the principal genes regulating this phenotype remain unidentified. Consequently, this study conducted a transcriptome comparative analysis of the skin between wild-type (M) and mutant (N) Taiwanese loaches. A total of 6,152 differentially expressed genes (DEGs) were identified, comprising 2,467 down-regulated and 3,685 up-regulated DEGs in mutant individuals. Additionally, several pigmentation-related genes (mitf, wnt3, mc1r, wnt1, dct, tyrp1, and tyr) were identified. KEGG enrichment analysis of DEGs revealed pathways associated with melanin deposition, including the melanogenesis, tyrosine metabolism, and folate biosynthesis pathways. Eleven DEGs were randomly selected to validate RNA-seq results through qPCR. Furthermore, key genes (tyr, mc1r) were validated through gene knockout, accurately identifying the main gene responsible for color mutation in the Taiwanese loach. This study not only offers new insights into the molecular mechanism underlying abnormal body color in the Taiwanese loach but also demonstrates that gene knockout technology can rapidly produce a large quantity of golden-red loaches, significantly enhancing their economic value. - Source: PubMed
Publication date: 2026/05/11
Li RongyunBai XiaohuiCao XiaojuanHao ShuangLiu KemingLuo ZhangGao JianWang YaoxinZhang YunbangMa LinJiang Jufeng - Radix Polygalae is a traditional Chinese herbal medicine with various pharmacological effects, including improvement of cognitive ability, anti-neurodegenerative property, and antiviral property, among others. Radix Polygalae was also utilized in the treatment of vitiligo in traditional folk clinics, although its mechanism of action remains unclear. This study investigates the potential active ingredients of Radix Polygalae in the treatment of vitiligo. - Source: PubMed
Publication date: 2026/05/04
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