ZNF271 antibody - N-terminal region (ARP35804_P050)
- Known as:
- ZNF271 (anti-) - N-terminal region (ARP35804_P050)
- Catalog number:
- arp35804_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- ZNF271 antibody - N-terminal region (ARP35804_P050)
Related genes to: ZNF271 antibody - N-terminal region (ARP35804_P050)
- Gene:
- ZNF271P NIH gene
- Name:
- zinc finger protein 271, pseudogene
- Previous symbol:
- ZNF271
- Synonyms:
- HZF7, ZNFEB
- Chromosome:
- 18q12.2
- Locus Type:
- pseudogene
- Date approved:
- 1999-07-19
- Date modifiied:
- 2014-11-19
Related products to: ZNF271 antibody - N-terminal region (ARP35804_P050)
Related articles to: ZNF271 antibody - N-terminal region (ARP35804_P050)
- Although new genes and regulatory events have been linked to the uniqueness of human brain development, it is unknown whether alternative polyadenylation (APA) also contributes to shaping this key feature that differentiates humans from other species. Here, we present an atlas of APAs of the human brain and identified 161 development-related, open-reading-frame-disrupting APAs associated with the dynamic translation of protein products. Among the genes affected by these events, we identified ZNF271P, which encodes a human-specific protein when using the distal polyadenylation site, a site that preferentially occurs during early brain development. The cortical organoids derived from ZNF271P-knockout human embryonic stem cells seemed to exhibit accelerated development and maturation, resulting in a significant decrease in organoid size, implicating that ZNF271P is involved in features unique to human brain development. We thus highlight APAs as new regulators in shaping the unique aspects of human brain development. - Source: PubMed
Li TingMo FanQi JianhuanLi ChunqiongLi XiangshangZhang JieLu YingfeiYao ChaoZhang LiHu BaoyangLi Chuan-YunAn Ni A - The transition of maternal to zygotic gene expression regulation is critical for human preimplantation embryo development. In recent years, single-cell RNA sequencing (scRNA-seq) had been applied to detect the factors that regulate human oocyte maturation and early embryo development. Here, the evaluation of transcriptomes in single blastomere from the embryo collected from patients by scRNA-seq was performed. There were 20 blastomeres biopsied from 8-cell embryos of seven patients who received more than two ART cycles due to low embryo competence. Meanwhile, ten cells were collected from 8-cell embryos of four patients who received ART treatment due to male or tubal factors. The blastomeres were then evaluated using the previously established scRNA-seq method to determine the associations between their gene expression and developmental competence. The total number of genes detected in 8-cell embryos that failed to form blastocyst including maternal and zygotic mRNAs was reduced. There were 324 differently expressed genes detected among the 8-cell embryos including 65 genes that were significantly suppressed in the 8-cell embryos that failed to form blastocyst. Further analysis found these 8-cell embryos arrested at the cleavage stage due to the dysfunction of the cell cycle, DNA transcription activity, histone methylation, and cell division-related genes such as SMCO-1, ZNF271P,ZNF679, ASF1b, BEX3, DPPA2, and ORC4. The alterations of gene expression detected in human 8-cell embryos are tightly associated with its developmental competence and could be used as targets to enhance embryo development or parameters to predict the embryo's development outcomes. - Source: PubMed
Publication date: 2023/04/19
Wang WeizhouZhao MengmengZuo HaiyangZhang JingyaoLiu BinChen FuJi PengyunLiu GuoshiGao ShuaiShang WeiZhang Lu - EBV is a human tumor virus that infects and establishes latency in the majority of humans worldwide. In vitro, EBV growth transforms primary B lymphocytes into lymphoblastoid cell lines with high efficiency. We have used cDNA subtraction cloning to identify cellular target genes required for growth transformation and identified a new C(2)H(2) (Krüppel-type) zinc finger gene, ZNF(EB), that is trans-activated early following EBV infection. In this study, we characterize ZNF(EB), including its intronless locus, and human and mouse protein variants. The gene is transiently expressed during normal lymphocyte activation, and its expression is sustained in EBV-positive but not EBV-negative B cell lines. There is limited expression in nonhemopoietic tissues. Its critical role in the growth transformation of B lineage cells is indicated by the abrogation of transformation with antisense strategies. ZNF(EB) maps to chromosome 18q12, a region with mutations in numerous, predominantly hemopoietic malignancies. - Source: PubMed
Tune Cathryn EPilon MarcSaiki YurikoDosch H-Michael