CDKN2D antibody
- Known as:
- CDKN2D (anti-)
- Catalog number:
- orb100506
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Biorbyt biorb
- Gene target:
- CDKN2D antibody
Related genes to: CDKN2D antibody
- Gene:
- CDKN2D NIH gene
- Name:
- cyclin dependent kinase inhibitor 2D
- Previous symbol:
- -
- Synonyms:
- INK4D, p19
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1995-07-06
- Date modifiied:
- 2016-10-05
Related products to: CDKN2D antibody
Related articles to: CDKN2D antibody
- The possibility of enhancing T cell function by deleting specific genes represents a long-sought goal in preclinical studies and ultimately for clinical applications. Using CRISPR/Cas9 genome editing, we report that, in human cytotoxic CD8 T cell clones, the cell cycle checkpoint gene CDKN2A, encoding p16, plays a nonredundant role in controlling T cell receptor (TCR)-dependent and independent cell expansion. Deletion of CDKN2A dramatically enhanced antigen-driven and homeostatic proliferation, while preserving effector functions. In contrast, the deletion of other cell cycle inhibitors (CDKN1B, CDKN2C, and CDKN2D), alone or in combination, had no impact on T cell proliferation. We also report that mediator complex subunit 12 (MED12) and the E3 ubiquitin ligase CBL-B deletions did not affect proliferative capacity of CD8 T cell clones. Interestingly, deletion of the negative regulator of Ras signaling, RASA2, increased antigen sensitivity and cytotoxic activity, while not improving in vitro expansion. Collectively, these findings reveal a unique and critical nonredundant role for p16 in regulating CD8 T cells. Deletion of CDKN2A offers a promising strategy to enhance CD8 T cell expansion ex vivo, thereby improving TCR discovery pipelines and, potentially, therapeutic applications. - Source: PubMed
Fiori SilviaAdragna CeciliaMalvicini EmiliaBasini TommasoGalgano DonatellaScarpa EdoardoJovic SandraSchmacke Niklas AHornung VeitSallusto FedericaBruno LudovicaLanzavecchia AntonioAlbanese Manuel - Atrial fibrillation (AF) is the most common and clinically significant arrhythmia requiring treatment. Although an imbalance between the sympathetic and vagal branches of autonomic nervous system (ANS) is known to trigger and sustain AF, the underlying mechanisms remain incompletely understood. Furthermore, there are yet no clinically authorized antiarrhythmic drugs currently targeting the modulation of ANS. - Source: PubMed
Publication date: 2026/05/22
Zhang XiaohanDu YihangShi ShuqingLiu YuandongYe ZelinChai RuoningFeng MeiyuLi JiaranZhang LimeiSong QingqiaoDu BaiHu Yuanhui - Leishmania donovani can cause visceral leishmaniasis, clinically manifested as fever, hepatosplenomegaly, and anemia. If left untreated, it may lead to death owing to complications from other diseases and infections. However, the pathogenesis of L. donovani infection remains unclear. - Source: PubMed
Publication date: 2026/03/13
Li Fei-RanSun QiWang QingQu Ling-LinLi Zhi-HuiYi Zheng-JunYang Bin-Bin - Transthyretin (TTR) amyloid deposition in the tenosynovium in carpal tunnel syndrome (CTS) is a potential early manifestation of systemic amyloidosis. However, its effects on tenosynovial fibroblasts in CTS remain unclear. We aimed to clarify how wild-type and Val30Met mutant TTR amyloids affect tenosynovial fibroblasts in CTS. - Source: PubMed
Publication date: 2026/02/12
Yamanaka YoshiakiTsujimura YoshitakaNaito ToichiroSato NaohitoTsukamoto ManabuSuzuki HitoshiZenke YukichiSakai Akinori - PURPOSE: Inflammation is a key contributor to the pathogenesis and progression of heart failure (HF), correlating with increased morbidity and mortality. This study aimed to evaluate the molecular impact of a 24-week nutritional intervention on inflammasome-related components in HF patients, comparing a Mediterranean diet alone versus the same diet supplemented with hypercaloric, high-protein oral nutritional supplements (ONS) enriched with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). In a cohort of 38 patients, expression levels of inflammasome markers were assessed via microfluidic quantitative polymerase chain reaction (PCR) in peripheral blood mononuclear cells at baseline and post-intervention. RESULTS: Some components, especially cytokines and apoptosis regulation components are overexpressed in patients with sarcopenia (NLRP1, NLRC4, CASP1, CASP5, CTSL, IFI16, TLR8, PSXR7, CCR1, CHUCK, MAPK14, CDKN1B). We observed a significant downregulation of Nod-like receptors NLRP12 and NLRP6, along with decreased expression of inflammasome activation components CASP5, TLR2, and TLR9 in the intervention group (p < 0.05). Additionally, cytokines and inflammation-related molecules such as CXCR1, CXCR2, TGFB, CCL2, and NF-κB showed reduced expression, while the inhibitor CHUCK increased (p < 0.05). Cell cycle regulators also shifted, with decreased CDKN2D expression (p < 0.05), suggesting potential effects on cellular senescence and DNA repair pathways. Notably, these molecular changes were absent in patients adhering solely to the Mediterranean diet. CONCLUSIONS: these findings suggest that supplementing a Mediterranean diet with hypercaloric, high-protein, EPA and DHA-enriched ONS induces molecular modifications in inflammasome pathways associated with cardiac remodeling. Therefore, targeted nutritional strategies may offer a promising adjunct to improve cardiac function and disease progression in HF patients. - Source: PubMed
Publication date: 2026/02/03
Herrera-Martínez Aura DHermán-Sánchez NataliaG-García Miguel EMuñoz-Jiménez ConcepciónPérez-Gómez Jesús MMontero-Hidalgo Antonio JLópez-Aguilera JoséGonzález-Manzanares RafaelGálvez-Moreno María ÁngelesMolina-Puerta María JoséLuque Raúl M