Ask about this productRelated genes to: SSSCA1 antibody
- Gene:
- ZNRD2 NIH gene
- Name:
- zinc ribbon domain containing 2
- Previous symbol:
- SSSCA1
- Synonyms:
- p27
- Chromosome:
- 11q13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-12-15
- Date modifiied:
- 2019-03-21
Related products to: SSSCA1 antibody
Related articles to: SSSCA1 antibody
- Nucleoproteins (N) of negative-sense RNA viruses exhibit an inherent tendency to oligomerize, forming a ribonucleoprotein complex that protects the viral genome. Here, immunoprecipitation coupled with mass spectrometry is used to identify zinc ribbon domain containing 2 (ZNRD2) as a host interactor for the respiratory syncytial virus (RSV) N protein. The results demonstrated that ZNRD2 functions as a restriction factor against RSV by enhancing the oligomerization and insolubility of N. Conversely, RSV N sequesters ZNRD2 into an insoluble aggregate, rendering it incapable of performing physiological functions required for the quality control of chaperonin assembly. Notably, RSV phosphoprotein (P) completely inhibited the formation of the insoluble ZNRD2-RSV N complex by maintaining N in a monomeric conformation. RSV infection induces a fluctuation in the solubility of ZNRD2, indicating a dynamic interaction between the host protein and the virus. These results reveal a dual antagonistic mechanism, whereby the host uses ZNRD2 to restrain RSV infection by aggregating with N, whereas the virus undermines ZNRD2's physiological functions. This study advances the molecular understanding of virus-host interactions and may provide insights into the development of novel antiviral strategies against RSV. - Source: PubMed
Publication date: 2026/01/21
Zhou HaiwuHe MingbinDu JinhongLiu CongWang WeiweiHan YuewenLi ZhifeiQin YaliChen Mingzhou - Copper is an essential trace element that supports numerous physiological functions; however, excessive copper accumulation can disrupt cellular and biological processes. In this study, forty-eight male mice were randomly divided into four groups (n = 12): Control (fed normal rice), Cu300 (300 mg/kg copper), Cu300+Se (Cu300 + selenium-enriched rice), and Cu300+iSe (Cu300 + 1 mg/kg iSe), and were treated for 180 days. Copper exposure resulted in reduced body weight, hepatomegaly and nephritis, elevated copper deposition in organs, oxidative stress, and significant declines in RBC, HGB, and WBC counts, leading to anemia and immunosuppression. Selenium supplementation, effectively mitigated these effects by reducing copper accumulation, restoring antioxidant balance, and enhancing selenoprotein-related functions. Histopathological analysis revealed that copper toxicity induced hydropic degeneration and focal necrosis in hepatic and renal tissues, effects that were significantly attenuated by selenium supplementation. Transcriptomic profiling revealed that selenium-enriched rice reversed copper-induced gene expression changes. In the liver, selenium treatment significantly upregulated protective genes such as , , , , and , while downregulating stress-related genes like , , , , and . In the kidneys, selenium enhanced the expression of detoxification and immune-modulating genes (, , , , ) and suppressed stress-related genes (, , , , ), demonstrating its role in mitigating oxidative and inflammatory stress. Collectively, these findings demonstrate that selenium-enriched rice exerts potent protective effects against chronic copper toxicity through multiple mechanisms: (1) restoration of mitochondrial function, (2) attenuation of ER stress and apoptosis, (3) enhancement of antioxidant and detoxification pathways, and (4) modulation of metabolic and immune responses. This study highlights selenium-enriched rice as a promising nutritional intervention for mitigating chronic copper toxicity and maintaining hepatorenal health. - Source: PubMed
Publication date: 2025/10/16
Panhwar Faiz HussainAhsan Muhammad ZahirJia XiaomeiYe XiaoyingChen RongjunLi LihuaZhu Jianqing - Cells contain numerous abundant molecular machines assembled from multiple subunits. Imbalances in subunit production and failed assembly generate orphan subunits that are eliminated by poorly defined pathways. Here, we determined how orphan subunits of the cytosolic chaperonin CCT are recognized. Several unassembled CCT subunits recruited the E3 ubiquitin ligase HERC2 using ZNRD2 as an adaptor. Both factors were necessary for orphan CCT subunit degradation in cells, sufficient for CCT subunit ubiquitination with purified factors, and necessary for optimal cell fitness. Domain mapping and structure prediction defined the molecular features of a minimal HERC2-ZNRD2-CCT module. The structural model, whose key elements were validated in cells using point mutants, shows why ZNRD2 selectively recognizes multiple orphaned CCT subunits without engaging assembled CCT. Our findings reveal how failures during CCT assembly are monitored and provide a paradigm for the molecular recognition of orphan subunits, the largest source of quality control substrates in cells. - Source: PubMed
Publication date: 2023/07/21
Yagita YuichiZavodszky EszterPeak-Chew Sew-YeuHegde Ramanujan S - Sjögren syndrome/scleroderma autoantigen 1 (SSSCA1) was first described as an auto-antigen over-expressed in Sjögren's syndrome and in scleroderma patients. SSSCA1 has been linked to mitosis and centromere association and as a potential marker candidate in diverse solid cancers. Here we characterize SSSCA1 for the first time, to our knowledge, at the molecular, structural and subcellular level. We have determined the crystal structure of a zinc finger fold, a zinc ribbon domain type 2 (ZNRD2), at 2.3 Å resolution. We show that the C-terminal domain serves a dual function as it both behaves as the interaction site to Tankyrase 1 (TNKS1) and as a nuclear export signal. We identify TNKS1 as a direct binding partner of SSSCA1, map the binding site to TNKS1 ankyrin repeat cluster 2 (ARC2) and thus define a new binding sequence. We experimentally verify and map a new nuclear export signal sequence in SSSCA1. - Source: PubMed
Publication date: 2020/03/13
Perdreau-Dahl HarmonieProgida CinziaBarfeld Stefan JGuldsten HanneThiede BerndArntzen MagnusBakke OddmundMills Ian GKrauss StefanMorth J Preben