Ask about this productRelated genes to: SIPA1L2 antibody
- Gene:
- SIPA1L2 NIH gene
- Name:
- signal induced proliferation associated 1 like 2
- Previous symbol:
- -
- Synonyms:
- KIAA1389, SPAR2
- Chromosome:
- 1q42.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-12-11
- Date modifiied:
- 2019-04-09
Related products to: SIPA1L2 antibody
Related articles to: SIPA1L2 antibody
- α-synucleinopathies are clinically and biologically heterogeneous disorders lacking reliable biomarkers to assist with early diagnosis, disease progression, patient stratification, and therapeutic targeting. Genetic variation is known to impact biomarker levels, influencing their utility and interpretation in research and clinical settings. We aimed to identify common genetic modulators of biomarker levels implicated in α-synucleinopathy pathogenesis. - Source: PubMed
Publication date: 2025/12/30
Somerville Emma NLiu LangTa MichaelIwaki HirotakaSenkevich KonstantinAlcalay Roy NGan-Or Ziv - Striae gravidarum (SG), commonly known as stretch marks, are a frequent connective tissue alteration observed in pregnant women. The presence of SG can negatively impact postpartum women's self-perception, potentially resulting in diminished self-esteem and psychological issues, including anxiety and depression. The study aimed to evaluate the potential risk factors and genetic associations of SG within a Chinese Han population. - Source: PubMed
Publication date: 2025/10/13
Xiong LidanYang LifengHe HailunChen JianguoWang YinshuDong XiujuLi LiHan Yuanyan - Alzheimer's disease (AD) continues to be the sixth leading cause of death in the United States. Significant efforts are spent researching etiology and potential management strategies. Although minorities face a higher disease burden and are anticipated to make up 43% of the US population by 2060, most literature on inherited AD risk has been derived from studying European ancestry. Here we evaluate frequencies of top AD risk alleles for late-onset AD (LOAD) in African- (AA), Mexican- (MA) and non-Hispanic White (NHW)-American participants enrolled in the Health & Aging Brain Study-Health Disparities (HABS-HD) cohort to determine ethnicity-specific differential genetic architecture. - Source: PubMed
Publication date: 2025/06/19
Housini MohammadZhou ZhengyangAbdullah LubnaaPathak GitaAyoub ReemGutierrez JohnAndrews SheaPhillips NicoleO'Bryant SidBarber Robert - Subclinical hypothyroidism (SCH) is associated with multiple adverse outcomes in early pregnancy. This study aims to explore the regulatory mechanisms underlying histone lactylation modification in early pregnancy with SCH. Peripheral blood mononuclear cells were collected from early pregnant women with or without SCH. RNA sequencing (RNA-seq) and chromatin immunoprecipitation sequencing (ChIP-seq) analyses were performed to identify the transcriptional pattern and histone lactylation modification in early pregnancy with SCH. RNA-seq analysis revealed that the differentially expressed genes associated with the extracellular matrix exhibited a significant downregulation in early pregnancy with SCH (EP_SCH) compared to early pregnancy without SCH (EP), while those involved in apoptosis were significantly upregulated. In the ChIP-seq analysis, 1660 hypomodified and 766 hypermodified H3K18la-binding peaks were identified in the EP_SCH group compared to the EP group. The hypomodified genes in early pregnancy with SCH compared to its control were enriched in GO terms of apoptotic process and differentiation of immune cells. The genes with increased H3K18 lactylation in early pregnancy with SCH compared to its control were associated with the nervous system, female pregnancy, and the OXT signaling pathway. When RNA-seq data was integrated with ChIP-seq data, we found that the expression and H3K18la enrichment of KCTD7, SIPA1L2, HDAC9, BCL2L14, TXNRD1, and SGK1 were increased in early pregnancy with SCH compared to its control, which was further confirmed by RT-qPCR and ChIP-PCR analyses. This study identifies the changes in histone lactylation modification in early pregnancy with SCH. These findings provide novel insights into the regulatory mechanisms of SCH during early pregnancy. - Source: PubMed
Publication date: 2025/04/19
Cheng ChaofeiGuo LizhenXu YinjuanXiong RongzhuZheng LeirongPeng YanmeiHua Rui - The incidence of thyroid cancer (TC) increases year by year. It is necessary to construct a prognostic model for risk stratification and management of TC patients. Glutamine metabolism is essential for tumor progression and the tumor microenvironment. The present study aimed to develop a predictive model for TC using a glutamine metabolism gene set. Differentially expressed genes in cells with high glutamine metabolism levels from single cell RNA‑sequencing data were compared with genes differentially expressed between normal and TC tissues from The Cancer Genome Atlas Program data. Through Boruta feature selection methods and multivariate Cox regression, six crucial genes were identified for a risk‑scoring system to develop a prognostic model. The role of each gene was verified in TC cells . A risk‑scoring system was developed according to the glutamine gene set to forecast the overall survival of TC patients. This risk score could stratify TC patients and minimize unnecessary surgeries and invasive treatments. In addition, signal induced proliferation associated 1 like 2 (SIPA1L2), an important gene in the prognostic model, knockdown in TPC‑1 and BCPAP cell lines enhanced TC cell proliferation, migration and invasion. A risk model was developed based on a glutamine metabolism gene set. The model has reference values for TC stratification. - Source: PubMed
Publication date: 2025/04/04
You YiZhou YuhengChen ZiluDeng LongchengShen YapingWang QinLong WeiXiong YanTan FoxingDu HaolinYang YanZhong JiangGe YunqianLi YouchenHuang Yan