Ask about this productRelated genes to: GATM antibody
- Gene:
- GATM NIH gene
- Name:
- glycine amidinotransferase
- Previous symbol:
- -
- Synonyms:
- AGAT
- Chromosome:
- 15q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-02-20
- Date modifiied:
- 2016-10-05
Related products to: GATM antibody
Related articles to: GATM antibody
- Diabetic foot ulcer (DFU) is a serious complication of diabetes with poor healing and high mortality, and effective diagnostic and treatment strategies are still insufficient. - Source: PubMed
Publication date: 2026/05/21
Wang WentingXia ZhengguoWang YinWang FanHan Feng - The mitochondrial genetic basis of intervertebral disc degeneration (IVDD) remains incompletely understood. This study employed multi-omics Mendelian randomization (MR) analysis to investigate the potential mitochondrial-related genetic mechanisms underlying IVDD. Using two-sample MR, we integrated and analyzed multi-omics quantitative trait loci, encompassing methylation, expression, protein abundance, and mitochondrial DNA, from genome-wide association studies (GWAS). Genetic associations with IVDD were obtained from the FinnGen study for discovery and the GWAS Catalog database for validation, with Steiger filtering and co-localization analysis further performed to strengthen causal inference. Additionally, Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and drug prediction analyses were comprehensively employed to identify potential therapeutic targets. Our multi-omics evidence identified 23 genes, among which 5 genes (glycine amidinotransferase [GATM], SLC25A13, acyl-CoA dehydrogenase short [ACADS], TSFM, and ATP23) showed tier 1 evidence for IVDD, with GATM demonstrating the strongest support. MR analysis revealed that a higher level of GATM was associated with a reduced risk of IVDD (odds ratio: 0.934, 95% confidence interval, 0.887-0.983). Furthermore, 15 drugs targeting GATM were identified, with HYDRONIDONE completing molecular docking. Through the integration of multi-omics data, we identified 5 promising therapeutic targets for IVDD, with GATM exhibiting the most consistent multi-omics signal, and discovered 15 drugs targeting GATM and 11 drugs targeting ACADS. - Source: PubMed
Xu FangxingWang ChaoSun MengShi ShuaiWang XuyaoLiu DonghuiYu LianhaoXi ChunyangKong Pengyu - This study aimed to elucidate the role of ROS-related genes in esophageal squamous cell carcinoma (ESCC) prognosis and the cellular mechanisms involving FOXM1 and SESN2. A prognostic model incorporating six genes (FOXM1, SESN2, APOD, GATM, HEBP2, STAT1) was developed using three ESCC gene expression datasets via univariate Cox regression, LASSO-Cox algorithm, and multivariate validation. Functional assays revealed that FOXM1 knockdown elevated intracellular ROS and malondialdehyde (MDA) levels while reducing total glutathione and antioxidant capacity, impairing proliferation, migration, and cell cycle progression. RNA-seq and luciferase assays confirmed SESN2 as a transcriptional target of FOXM1. Dual knockdown of FOXM1 and SESN2 exacerbated oxidative stress, decreased mitochondrial membrane potential, and increased cell death, accompanied by mitochondrial morphological changes (reduced shrinkage, increased membrane density). Western blotting showed decreased BCL2 and GPX4 expression but increased LC3-II and -mTOR levels. These findings demonstrate that the FOXM1-SESN2 axis shields ESCC cells from oxidative stress, offering a rationale for future mechanistic investigations. - Source: PubMed
Publication date: 2026/05/05
Wu ZhishengZhang XiaonaChen MantongGao ChenmengZheng XiaoqiPeng ZhongteDu ZepengWu Bingli - Ovarian cancer (OC) and cervical cancer (CC) are major causes of gynecological malignancy mortality, but their spatially resolved metabolic features and shared progression-driving metabolic reprogramming remain unexplored. This study integrated spatial metabolomics, proteomics, and targeted metabolomics with assays to explore their metabolic reprogramming and therapeutic targets. The results revealed that OC exhibits intratumoral metabolic heterogeneity and suppresses tryptophan and vitamin B6 metabolism, with ferroptosis-related proteins upregulated in metastatic lesions and ALDH7A1/GATM knockdown promoting its cell proliferation and migration. CC progression was marked by amino acid and bile acid accumulation and neomenthol-driven cell proliferation. Purine metabolism activation was identified as a shared hallmark of both cancers, and purine nucleoside phosphorylase (PNP) knockdown was found to inhibit the proliferation of both OC and CC cells. This work identifies stage-specific metabolic vulnerabilities and PNP as a conserved therapeutic target, providing a framework for developing tailored gynecological cancer therapies. - Source: PubMed
Publication date: 2026/04/22
Ge YunxiaoLuo YanlinHao BingbingZhou YubingWu RuiLiu HangruiTang LinLi YuanyingLi YushuGong ShutingLiu Hui - This study aimed to identify a key target gene in proximal tubule cells (PTCs) of sepsis-induced acute kidney injury (S-AKI) and elucidate the underlying mechanisms. - Source: PubMed
Publication date: 2026/05/09
Yang RuhaoHu NiandanChen HairuiLi WenqiangZheng Ting