Ask about this productRelated genes to: ICAM1 antibody
- Gene:
- ICAM1 NIH gene
- Name:
- intercellular adhesion molecule 1
- Previous symbol:
- -
- Synonyms:
- BB2, CD54
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1989-04-24
- Date modifiied:
- 2016-01-15
Related products to: ICAM1 antibody
Related articles to: ICAM1 antibody
- Excessive dietary salt intake is a well-established risk factor for hypertension, with numerous underscoring its significant role in the pathogenesis of cardiovascular diseases. Dietary management is widely recognized as essential for both the prevention and treatment of hypertension. This study aimed to evaluate the preventive efficacy of a sulfonated peptide, Leucyl-glycyl-asparaginyl-glycyl-cysteinylsulfonic acid-proline (Leu-Gly-Asn-Gly-Cya-Pro, SLP), against high-salt-induced hypertension and renal injury, thereby providing new insights into hypertension prevention strategies. Compared with the unsulfonated peptide, Leucyl-glycyl- asparaginyl-glycyl-cysteinyl-proline (Leu-Gly-Asn-Gly-Cys-Pro, LP), SLP was more effective in attenuating the elevation of blood pressure, inhibiting renal fibrosis, improving markers of renal injury (alpha-1-microglobulin and uric acid), and reducing levels of inflammatory factors and adhesion molecules (intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and interleukin-1β). Additionally, SLP upregulated endothelial nitric oxide synthase while downregulating inducible nitric oxide synthase in the kidney. Similarly, high levels of nuclear factor-kappa B and phosphorylated nuclear factor-kappa B induced by high-salt in the kidney were effectively prevented by SLP treatment. Furthermore, SLP exerted antihypertensive effects through the regulation of tryptophan, purine, glycerophospholipid, and cysteine metabolism, as well as the citrate cycle. Overall, sulfonation modification enhances the anti-inflammatory and metabolic regulatory activities of peptides, with the sulfonated peptides SLP significantly preventing high-salt-induced hypertension and its associated renal complications. - Source: PubMed
Publication date: 2026/05/22
Li YuexiuSong SiyiLin QianxiaJin Huoxi - Chlorfenapyr, a novel pyrrole-class insecticide, can induce acute myocardial injury and cardiotoxicity. This study aimed to investigate its potential targets through network toxicology and transcriptomic profiling. - Source: PubMed
Publication date: 2026/05/23
Xu XinbingWang ChunxiaoLi HaoSun LinSong JuanjuanLiu FangwenDeng Ying - Infectious diseases exacerbate atherosclerosis-associated morbidity and mortality by inducing sustained inflammatory responses characterized by elevated IL-6, TNF-α, IFN-γ, and CXCL10. Persistent CXCL10-driven recruitment of CXCR3⁺ immune cells promotes endothelial dysfunction and atherosclerotic progression. Although mesenchymal stem cells (MSCs) respond to inflammatory cues and secrete CXCL10, the contribution of CXCL10/CXCR3 signaling to intrinsic MSC immunomodulatory programming remains poorly understood. The objective of this study is to investigate whether CXCL10 signaling can modulate MSC-mediated immunoregulation. To address this, Wharton's jelly-derived MSCs (WJ-MSCs) were genetically engineered to express a membrane-anchored CXCL10-Lactadherin C1/C2 fusion protein (CXCL10-LACTC1/C2). This strategy was designed to recapitulate physiological, localized, and sustained CXCL10 signaling, enabling spatially restricted chemokine presentation that more closely mimics cell-associated CXCL10 in inflammatory microenvironments compared with soluble CXCL10. The Lactadherin C1/C2 domain was selected to achieve stable, physiological membrane anchoring without introducing artificial transmembrane domains or compromising CXCL10 bioactivity. CXCL10-LACTC1/C2-expressing MSCs exhibited increased expression of key immunoregulatory mediators, including IDO1, TGF-β1, and IL4I1. Furthermore, conditioned medium derived from these MSCs attenuated TNF-α-induced inflammatory responses in human umbilical vein endothelial cells (HUVECs), as indicated by the modulation of endothelial activation and homeostasis markers (ICAM-1, PECAM-1, KDR, vWF, and NRF2) and improvement of cell viability. Collectively, these findings provide mechanistic insight into CXCL10-mediated MSC immunoregulation and support further investigation of MSC-based and cell-free therapeutic strategies aimed at mitigating CXCL10-driven endothelial inflammation in infection-associated vascular injury and atherosclerotic disease progression. - Source: PubMed
Publication date: 2026/05/22
Molo KayaEge RukenAti̇k KübraÇıtak ElifÇulcuoğlu OrçunDarıcı HakanOrdu Emel - Traditional Chinese medicine QingYiHuaJi formula (QYHJ) has anti-tumor effect in Pancreatic adenocarcinoma (PAAD). However, the potential mechanism and key targets of QYHJ have not been fully elucidated. - Source: PubMed
Han JintaoQian FuchuShi Jiemin - Dachaihu Decoction (DCHD), a traditional herbal formula from Shanghan Lun, has been widely used in the management of hyperlipidemia. However, the comparative efficacy of its modified formulations and their underlying mechanisms remain unclear. This study aimed to evaluate the therapeutic efficacy of DCHD and its modifications and to elucidate the potential mechanisms using integrated analytical strategies. - Source: PubMed
Publication date: 2026/04/25
Bu WenyuLi HanxueZhu ShidianLiu YanziXia YinghongLiu Fuming