HNRPF Blocking Peptide
- Known as:
- HNRPF Blocking Peptide
- Catalog number:
- 33r-5245
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- HNRPF Blocking Peptide
Related genes to: HNRPF Blocking Peptide
- Gene:
- HNRNPF NIH gene
- Name:
- heterogeneous nuclear ribonucleoprotein F
- Previous symbol:
- HNRPF
- Synonyms:
- -
- Chromosome:
- 10q11.21
- Locus Type:
- gene with protein product
- Date approved:
- 1997-08-28
- Date modifiied:
- 2015-09-08
Related products to: HNRPF Blocking Peptide
Related articles to: HNRPF Blocking Peptide
- Foamy viruses (FVs) are capable of cross-species transmission to humans and establish latent infections without causing diseases. The transition between latent and lytic FV replication is regulated by the viral proteins Bet and Tas, which are expressed predominantly from the internal promoter (IP). Bet suppresses basal IP activity and initiates latency, whereas Tas activates the IP and the long terminal repeat (LTR) promoter and enables lytic infection. However, the mechanisms regulating the relative levels of Tas and Bet are not completely understood. - Source: PubMed
Publication date: 2026/04/04
Wu ShishunLiu ChenxiQiu ManmanTan JuanQiao Wentao - Circular RNAs (circRNAs) have emerged as significant regulators of cancer biology. However, the characterization and the regulatory potential of circRNAs deriving from key apoptotic genes remain poorly understood in breast cancer. We aimed to comprehensively characterize circRNAs originating from the pro-apoptotic gene and predict their regulatory potential in BC signaling. Targeted amplification of circular transcripts was conducted in eleven cancerous and one non-cancerous breast cell lines, followed by third-generation (nanopore) and next-generation sequencing. Finally, extensive bioinformatic analysis was conducted. Therefore, we identified 106 circRNAs, 82 of which were novel. These circRNAs exhibited diverse biogenesis features, including exon skipping, intron retention, and rare inclusion of exon 5. Expression profiling revealed subtype-specific patterns, with several circRNAs being detected only in triple-negative or luminal BC subtypes, while circ-BAX-55b was detected exclusively in the non-cancerous cell line. Many circRNAs were predicted to sponge miRNAs such as miR-152-5p, miR-4802-5p, and miR-3619-5p, potentially modulating signaling pathways including MAPK, PI3K/AKT, and NFκB. Extensive sponging of miR-152-5p, which targets mRNA, suggests a feedback mechanism modulating apoptosis. Several circRNAs also contain binding sites for RNA-binding proteins (RBPs) such as RBM6 and HNRNPF, possibly dictating RNA fate. Overlapping miRNA and RBP-binding sites imply complex competitive or cooperative interactions. Additionally, multiple circRNAs, such as circ-BAX-6c, displayed translation-related features. In conclusion, these findings reveal a novel repertoire of circRNAs with putative roles in BC signaling and apoptosis regulation. Moreover, they constitute a valuable resource for functional studies as well as potential biomarkers or therapeutic targets in breastcancer. - Source: PubMed
Publication date: 2026/03/17
Katsaraki KaterinaVatsellas GiannisKontos Christos K - Pork is a major source of animal protein for humans, and as living standards have improved, consumer demand has shifted from quantity to quality. Amino acid and fatty acid compositions determine the nutritional value and flavor of pork. However, the genetic mechanisms underlying variation in these parameters have not been fully elucidated. In this study, we quantified 17 amino acids and 42 fatty acids in the muscle from three crossbred pig populations, namely Yorkshire × Tibetan (YT), Yorkshire × Neijiang (YN), and Duroc × Tibetan (DT). YT and YN pigs exhibited higher amino acid concentrations, while DT pigs showed elevated fatty acid levels. Subsequently, whole-genome resequencing of 73 pigs identified 24,125,658 high-quality SNPs, among which 146 were significantly associated with fatty acid traits, leading to the identification of 19 candidate genes linked to palmitic acid (i.e., , and ), oleic acid (i.e., , and ), and total fatty acids (i.e., ). Functional annotation revealed that these candidate genes participate primarily in pathways related to lipid metabolism, glucose homeostasis, and energy balance. The identified SNPs and candidate genes provide valuable insights into the genetic architecture of the fatty acid composition in pork and may serve as molecular targets for improving meat quality through breeding. - Source: PubMed
Publication date: 2026/01/29
Tang JieLiang YanAn RuiLuo GanTao XuanLiu PengliangGu Yiren - - Source: PubMed
Publication date: 2026/01/29
Dong ShuchenTeng YueLi XingwangSun XiaofengZhu Huayun - The mitogen-activated extracellular signal-regulated kinase/extracellular signal-regulated kinase (MEK/ERK) signaling plays a dual role in regulating the self-renewal and differentiation of embryonic stem cells (ESCs). How MEK/ERK promotes ESC self-renewal remains elusive, while the mechanisms for MEK/ERK to stimulate ESC differentiation have been investigated extensively. Here, we demonstrated that ERK2 phosphorylates heterogenous nuclear ribonucleoprotein F (HNRNPF) on Ser346 and Tyr356. Hnrnpf knockout reduces ESC proliferation rate, through downregulating CDK1 and CCNB1, and promotes ESC differentiation, attributed to reduced EED. Moreover, compared with the unphospho-mimetic mutant, the phospho-mimetic HNRNPF is more potent in rescuing ESC growth, as well as suppressing the mesodermal and trophectodermal differentiation. Mechanistically, HNRNPF binds to Cdk1, Ccnb1, and Eed messenger RNAs (mRNAs), thereby enhancing their translation efficiency. Additionally, phosphorylation of HNRNPF enhances its binding to these mRNAs and promotes their translation. Taken together, ERK may facilitate ESC proliferation and suppress lineage differentiation through phosphorylating HNRNPF. - Source: PubMed
Duan XiaoweiWang YuyingZhang JingaiZhao NannanHao QianyiYang XiaoqiongDu XiaolingYang HongjieLiang HuabinChen Lingyi