Ask about this productRelated genes to: SOHLH1 Blocking Peptide
- Gene:
- SOHLH1 NIH gene
- Name:
- spermatogenesis and oogenesis specific basic helix-loop-helix 1
- Previous symbol:
- C9orf157
- Synonyms:
- NOHLH, TEB2, bA100C15.3, bHLHe80, SPATA27
- Chromosome:
- 9q34.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-05-27
- Date modifiied:
- 2019-03-19
Related products to: SOHLH1 Blocking Peptide
Related articles to: SOHLH1 Blocking Peptide
- Spermatogonial differentiation is a key step in spermatogenesis, yet the transcriptional programs that control this process are not fully defined. E4f1 has been reported to be essential for embryonic development, mitochondrial function and spermatogonial stem cell (SSC) maintenance in mice. However, its function in spermatogonial differentiation and meiosis progression is unknown. - Source: PubMed
Publication date: 2026/04/14
Wang Fei-ChenHe ZhenYan Rong-GeWang Yu-JunWu Jia-LuYang Qi-En - To investigate the inhibitory effect of polyphyllin VII (PP7) on osteosarcoma xenograft growth in mice and explore the underlying molecular mechanism. - Source: PubMed
Xiao DantingTang HaijunYang MingxiuTeng HongcaiLiang JimingXie TianyuFeng WenyuLiu ShangyuDai WeiLi HeningLiu Yun - - Source: PubMed
Elmoryah MohamedErgen Fatima BSkaugen John MGestrich Catherine KBurgess Melissa AWeiss Kurt RJohn Ivy - Glioma stem-like cells (GSLCs) are tumour initiating cells that drive tumorigenesis and progression through self-renewal and various differentiation potencies. Therefore, the identification of genes required for GSLC stemness and differentiation is vital for the development of novel targeted therapies. Sohlh1 belongs to the superfamily of bhlh transcription factors and serves as a tumour suppressor in glioma. The role of Sohlh1 in GSLCs remains unknown. Here, we demonstrated that Sohlh1 functioned through the SFRP1/Wnt/β-catenin signalling pathway and led to the consequent suppression of GSLC stemness and the promotion of GSLC differentiation in vitro and in vivo. Moreover, Sohlh1 could directly bind to the promoter of SFRP1 and promote its transcriptional activity. SFRP1 mediated the effects of Sohlh1 on GSLC stemness and differentiation. Clinically, we observed a significant inverse correlation between Sohlh1 and Nestin expression levels, and a positive correlation between Sohlh1 and SFRP1 expression in glioma tissues. Collectively, our findings suggest an important role of the Sohlh1/SFRP1/Wnt/β-catenin pathway in regulating GSLC stemness and differentiation, suggesting potential therapeutic targets for glioma. - Source: PubMed
Zhi SujuanChen YanRuXiao YunlingLiu LanlanFeng XiaoningLiu XuyueShen YingZhang RuiHongHao Jing - Cryopreservation of testicular tissue has been proposed as a potential technique for preserving fertility in pre-pubertal boys with various malignancies. The present study aimed to compare the effects of two vitrification techniques-solid surface vitrification (SSV) and needle-immersed vitrification (NIV)-on the integrity, development, cell viability, and apoptosis of rat testicular tissue. Testes from 4-week-old Wistar rats underwent a two-step vitrification process. Tissue pieces were allocated to either the SSV or NIV group. Equilibration involved a solution containing 7.5 % dimethyl sulfoxide (DMSO) and 7.5 % ethylene glycol (EG), followed by a vitrification solution with 0.07 mol/L sucrose, 15 % DMSO, and 15 % EG. The optimal protocol was determined after vitrification using either the NIV or SSV technique. Samples from the control and selected vitrification (SSV) groups were cultured for 3 weeks. Tissue integrity, cell viability, apoptosis, and gene expression were evaluated using hematoxylin and eosin staining, trypan blue staining, annexin V-PI staining, and real-time PCR. Morphological changes were more pronounced in the NIV group compared to the SSV group (P < 0.05). Although the percentage of viable cells did not significantly differ between the NIV and SSV groups, it was slightly higher in the SSV group. Thus, SSV was identified as the optimum vitrification method. Real-time PCR analysis revealed altered gene expression: spermatogonial-related genes (Lrp4, Egr3, Nanos, Gfra1, C-kit, and Sohlh1) were significantly decreased in the SSV group, while somatic-cells-related genes (Gdnf, Csf1, and Fgf2) were higher. Overall, SSV appears suitable for rat testis tissue vitrification, although it induces some molecular changes. Optimization of the culture medium is essential to support successful spermatogenesis. - Source: PubMed
Publication date: 2025/03/04
Sharbatoghli MinaHajiaghalou SamiraDeheshkar Gooneh Farahani Nafiseh SadatAghajanpour SamanehShahverdi AbdolhosseinRezazadeh Valojerdi MojtabaEbrahimi Bita