Ask about this productRelated genes to: KCNJ4 Blocking Peptide
- Gene:
- KCNJ4 NIH gene
- Name:
- potassium voltage-gated channel subfamily J member 4
- Previous symbol:
- -
- Synonyms:
- Kir2.3, HIR, HRK1, hIRK2, IRK3
- Chromosome:
- 22q13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1995-04-13
- Date modifiied:
- 2016-02-04
Related products to: KCNJ4 Blocking Peptide
Related articles to: KCNJ4 Blocking Peptide
- Epilepsy is a common neurological disorder with a strong genetic basis, most frequently arising from ion channel dysfunction. Although multiple inwardly rectifying potassium (Kir) channels have been implicated in epileptogenesis, the contribution of KCNJ4, which encodes the Kir2.3 channel, has not previously been established in human epilepsy. The present study aimed to identify pathogenic KCNJ4 variants and to elucidate their functional consequences in the context of epilepsy. - Source: PubMed
Publication date: 2026/03/14
Pan HuLiu DengXu WuhenLi YangHu JuanliHenry OppermannFuchs AlexanderJamra Rami AbouLiu ZhenHe MeiChen YuanluWu ShengnanDong XiaohuanChen YiqiaoWang PengchaoGu WeiyueJing HanTang YabingWang Ya-JieMao XiaoXiao Neng - Atrial fibrillation (AF) is a heart rate disorder associated with a high disability rate. A number of genes involved in core coding are also implicated in the development of AF. The striated preferentially expressed gene () is a newly discovered gene related to the pathogenesis of AF. It promotes disease development by participating in fibrosis and abnormal ion channel function. In this study, the high-risk genes of AF disease were screened by bioinformatics analysis, and the gene polymorphism and gene expression of AF related genes were further analyzed. - Source: PubMed
Publication date: 2025/03/27
Wei JiaochangYu LanqingLiu YuhuaYe ShaowuSong BoDeng YiminLu QianDeng Bailu - While some chronic pathological substrates for sudden cardiac death (SCD) are well known (eg, coronary artery disease and left ventricular [LV] dysfunction), the acute vulnerable myocardial state predisposing to fatal arrhythmia remains a critical barrier to near-term SCD prevention. - Source: PubMed
Publication date: 2024/11/15
Caudal ArianneLiu YuPang Paul DMaison David PNakasuka KosukeFeng JeanSchwarzer-Sperber H SSchwarzer RolandMoffatt EllenHenrich Timothy JPadmanabhan ArunConnolly Andrew JWu Joseph CTseng Zian H - Myocardial infarction leads to myocardial necrosis, and cardiomyocytes are non-renewable. Fatty acid-containing cardiomyocyte maturation medium promotes maturation of stem cell-derived cardiomyocytes. - Source: PubMed
Mu JunshengGao ZhenBo PingYou Bin - Neurological disorders such as Alzheimer's, Parkinson's, amyotrophic lateral sclerosis, and schizophrenia are associated with altered neuronal excitability, resulting from dysfunctions in the molecular architecture and physiological regulation of ion channels and synaptic transmission. Ion channels and synapses are regarded as suitable therapeutic targets in modern pharmacology. Cannabinoids have received great attention as an original therapeutic approach for their effects on human health due to their ability to modulate the neurotransmitter release through interaction with the endocannabinoid system. In our study, we explored the effect of cannabinol (CBN) through next-generation sequencing analysis of NSC-34 cell physiology. Our findings revealed that CBN strongly influences the ontologies related to ion channels and synapse activity at all doses tested. Specifically, the genes coding for calcium and potassium voltage-gated channel subunits, and the glutamatergic and GABAergic receptors (, , , , , , , , , , ), were up-regulated. Conversely, the genes involved into serotoninergic and cholinergic pathways (, , , , , ), were down-regulated. These findings highlight the influence of CBN in the expression of genes involved into ion influx and synaptic transmission. - Source: PubMed
Publication date: 2024/09/19
Trainito AlessandraMuscarà ClaudiaGugliandolo AgneseChiricosta LuigiSalamone StefanoPollastro FedericaMazzon EmanuelaD'Angiolini Simone