Ask about this productRelated genes to: MDS032 antibody
- Gene:
- USE1 NIH gene
- Name:
- unconventional SNARE in the ER 1
- Previous symbol:
- -
- Synonyms:
- p31, SLT1, MDS032, D12
- Chromosome:
- 19p13.11
- Locus Type:
- gene with protein product
- Date approved:
- 2007-08-20
- Date modifiied:
- 2016-03-14
Related products to: MDS032 antibody
Related articles to: MDS032 antibody
- The SNARE protein USE1 plays a critical role in retrograde membrane traffic from the Golgi to the endoplasmic reticulum (ER) in yeast, yet its function in insects remains unclear. This study investigates the role of the RpUSE1 gene in the agricultural pest Riptortus pedestris. Domain analysis confirmed that RpUSE1 is a 248-amino-acid SNARE protein containing a C-terminal transmembrane domain and a SNARE motif featuring a conserved aspartate residue at the central "0" layer. It is ubiquitously expressed in R. pedestris, with the highest transcript levels in the female reproductive system. RNAi-mediated knockdown of RpUSE1 severely impaired nymph survival and development. Moreover, silencing RpUSE1 in adult females completely disrupted egg development and caused structural disorder of the lateral oviducts, including ER disorganization. Notably, there was a significant accumulation of lipid droplets within the lateral oviduct lumen. In contrast, silencing RpUSE1 in male adults did not affect fertility. These findings demonstrate that RpUSE1 is essential for nymphal survival and female reproductive success, highlighting its crucial role in maintaining organelle structure and intracellular transport. - Source: PubMed
Yang Yan-YanTian YingFeng Qing-KaiZhang Chuan-XiLu Jia-Bao - Lung cancer remains a leading cause of cancer-related mortality worldwide, highlighting the urgent need for rapid, accurate, and affordable diagnostic strategies. UBA6-specific E2 conjugating enzyme 1 (USE1) is overexpressed in lung cancer and contributes to tumorigenesis, yet no clinically applicable method exists for its detection. - Source: PubMed
Publication date: 2026/04/14
Kim Min-JeeYum KyuhaKim DajeongJang IksooPark AronJung MinJunLee Geun DongJin Jun-OIm WonpilLee Jong BumLee Peter Chang-Whan - Sub-Saharan Africa carries the highest global burden of critical illness, yet transcriptomic sepsis endotypes have not been defined in the region. Their clinical relevance and alignment with endotypes identified in high-income countries (HICs) remain unknown. - Source: PubMed
Publication date: 2025/07/29
Cummings Matthew JLutwama Julius JTomoiaga Alin SZhao MengOwor NicholasLu XuanEliku Peter JamesRoss Jesse ENsereko ChristopherNayiga IreneKyebambe StephenNsubuga John BoscoShinyale JosephAsasira IgnatiusKiyingi TonnyOchar ThomasKiwubeyi MosesNankwanga RittahReynolds Steven JNakibuuka Martina CathyKayiwa JohnHaumba MercyNakaseegu JoweriaChe XiaoyuNie KaiKim-Schulze SeungheeGhosh SankarLipkin W IanO'Donnell Max RBakamutumaho Barnabas - Stimulator of interferon genes (STING) traffics across intracellular compartments to trigger innate responses. Mutations in factors regulating this process lead to inflammatory disorders. To systematically identify factors involved in STING trafficking, we performed a genome-wide optical pooled screen (OPS). Based on the subcellular localization of STING in 45 million cells, we defined 464 clusters of gene perturbations based on their cellular phenotypes. A secondary, higher-dimensional OPS identified 73 finer clusters. We show that the loss of the gene of unknown function C19orf25, which clustered with USE1, a protein involved in Golgi-to-endoplasmic reticulum (ER) transport, enhances STING signaling. Additionally, HOPS deficiency delayed STING degradation and consequently increased signaling. Similarly, GARP/RIC1-RGP1 loss increased STING signaling by delaying STING Golgi exit. Our findings demonstrate that genome-wide genotype-phenotype maps based on high-content cell imaging outperform other screening approaches and provide a community resource for mining factors that impact STING trafficking and other cellular processes. - Source: PubMed
Publication date: 2024/12/09
Gentili MatteoCarlson Rebecca JLiu BingxuHellier QuentinAndrews JocelynQin YueBlainey Paul CHacohen Nir - A comprehensive study of soluble -ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) in the fly genome by RNAi in photoreceptors indicated that knockdown of any of the COPI-SNAREs, , , and , resulted in the same characteristic phenotypes: Golgi stacks gathering on their -side, laterally expanded Golgi cisternae, and a reduced number of discrete Golgi stacks. These Golgi stacks are reminiscent of mammalian Golgi ribbons and Brefeldin A (BFA)-bodies in S2 cells. As previously reported, BFA suppresses -Golgi network (TGN) fission and Golgi stack separation to form a BFA-body, which is a cluster of Golgi stacks cored by recycling endosomes. We found that the impairing each of COPI-SNAREs results in clustered Golgi stacks similar to BFA-bodies, indicating that COPI-SNAREs have a role to separate clustered Golgi stacks. These results further support the idea that the movement of Golgi stacks and the balance of fusion and fission of the TGN determine the level of clustering and ribbon formation of Golgi stacks within cells. - Source: PubMed
Publication date: 2024/09/04
Tago TatsuyaYamada YumiGoto YumiToyooka KiminoriOchi YukaSatoh TakunoriSatoh Akiko K