Ask about this productRelated genes to: GMEB2 antibody
- Gene:
- GMEB2 NIH gene
- Name:
- glucocorticoid modulatory element binding protein 2
- Previous symbol:
- -
- Synonyms:
- P79PIF, KIAA1269, PIF79
- Chromosome:
- 20q13.33
- Locus Type:
- gene with protein product
- Date approved:
- 2000-03-30
- Date modifiied:
- 2014-11-18
Related products to: GMEB2 antibody
Related articles to: GMEB2 antibody
- Induction of labor is commonly performed in pregnancies for clinical benefits, but 25% to 30% of inductions eventually fail and require cesarean delivery. So far, there is no biomarker for the prediction of successful vaginal birth after induction of labor, and clinical prediction remains unsatisfactory. - Source: PubMed
Publication date: 2025/06/14
Ding WenjingChim Stephen Siu ChungWong Karen Ka WingKo Elaine Yee LingChung Claire Yik LokTse Joyce Ka YuChan Ting FungWang Chi ChiuLeung Tak Yeung - Transcription factors are frequently aberrantly reactivated in various cancers, including colorectal cancer (CRC). However, as a transcription factor, the role of GMEB2 in cancer is still unclear, and further studies are needed. Here, we aimed to identify the function and mechanism of GMEB2 in regulating the malignant progression of CRC. GMEB2 was found to be highly expressed in online data analyses. We demonstrated that GMEB2 was markedly upregulated at both the mRNA and protein levels in CRC cells and tissues. GMEB2 knockdown inhibited CRC cell growth in vitro and in vivo. Mechanistically, as a transcription factor, GMEB2 transactivated the ADRM1 promoter to increase its transcription. Rescue experiments showed that ADRM1 downregulation partially reversed the promoting effects of GMEB2 on CRC growth in vitro. Moreover, the GMEB2/ADRM1 axis induced nuclear translocation of NF-κB, thus activating NF-κB signalling. Finally, we further revealed that YTHDF1 recognized and bound to the mA site on GMEB2 mRNA, which enhanced its stability. Taken together, our findings reveal the crucial role and regulatory mechanism of GMEB2 in CRC for the first time and provide a novel potential therapeutic target for CRC therapy. - Source: PubMed
Publication date: 2022/12/08
Ning ZhengpingWu ZhiweiZhang FanYang MingLu ZhixingYu BowenLong FeiGuo YihangYang KaiyanHu GuiZhang YiLi XiaorongLi LiangLin Changwei - Glioma accounts for approximately 80% of malignant adult brain cancer and its most common subtype, glioblastoma, has one of the lowest 5-year cancer survivals. Fifty risk-associated variants within 34 glioma genetic risk regions have been found by genome-wide association studies (GWAS) with a sex difference reported for 8q24.21 region. We conducted an Australian GWAS by glioma subtype and sex. - Source: PubMed
Alpen KarenVajdic Claire MMacInnis Robert JMilne Roger LKoh Eng-SiewHovey ElizabethHarrup RosemaryBruinsma FionaNguyen Tuong LLi ShuaiJoseph DavidBenke GezaDugué Pierre-AntoineSouthey Melissa CGiles Graham GRosenthal MarkDrummond Katharine JNowak Anna KHopper John LKapuscinski MiroslawMakalic Enes - Genome-wide association studies (GWAS) have identified single-nucleotide polymorphisms (SNPs) associated with glioma risk on 20q13.33, but the biological mechanisms underlying this association are unknown. We tested the hypothesis that a functional SNP on 20q13.33 impacted the activity of an enhancer, leading to an altered expression of nearby genes. To identify candidate functional SNPs, we identified all SNPs in linkage disequilibrium with the risk-associated SNP rs2297440 that mapped to putative enhancers. Putative enhancers containing candidate functional SNPs were tested for allele-specific effects in luciferase enhancer activity assays against glioblastoma multiforme (GBM) cell lines. An enhancer containing SNP rs3761124 exhibited allele-specific effects on activity. Deletion of this enhancer by CRISPR-Cas9 editing in GBM cell lines correlated with an altered expression of multiple genes, including STMN3, RTEL1, RTEL1-TNFRSF6B, GMEB2, and SRMS. Expression quantitative trait loci (eQTL) analyses using nondiseased brain samples, isocitrate dehydrogenase 1 (IDH1) wild-type glioma, and neurodevelopmental tissues showed STMN3 to be a consistent significant eQTL with rs3761124. RTEL1 and GMEB2 were also significant eQTLs in the context of early CNS development and/or in IDH1 wild-type glioma. We provide evidence that rs3761124 is a functional variant on 20q13.33 related to glioma/GBM risk that modulates the expression of STMN3 and potentially other genes across diverse cellular contexts. - Source: PubMed
Publication date: 2020/11/22
Ali Mourad WagdyPatro C Pawan KZhu Jacqueline JufenDampier Christopher HPlummer Sarah JKuscu CemAdli MazharLau ChingLai Rose KCasey Graham - Twenty-five germline variants are associated with adult diffuse glioma, and some of these variants have been shown to be associated with particular subtypes of glioma. We hypothesized that additional germline variants could be identified if a genome-wide association study (GWAS) were performed by molecular subtype. - Source: PubMed
Eckel-Passow Jeanette EDrucker Kristen LKollmeyer Thomas MKosel Matt LDecker Paul AMolinaro Annette MRice TerriPraska Corinne EClark LaurenCaron AlissaAbyzov AlexejBatzler AnthonySong Jun SPekmezci MelikeHansen Helen MMcCoy Lucie SBracci Paige MWiemels JosephWiencke John KFrancis StephenBurns Terry CGiannini CaterinaLachance Daniel HWrensch MargaretJenkins Robert B