Ask about this productRelated genes to: FMO4 antibody
- Gene:
- FMO4 NIH gene
- Name:
- flavin containing monooxygenase 4
- Previous symbol:
- FMO2
- Synonyms:
- -
- Chromosome:
- 1q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-01
- Date modifiied:
- 2015-09-11
Related products to: FMO4 antibody
Related articles to: FMO4 antibody
- Osteoarthritis (OA) is a progressive joint disease influenced by macrophage-associated efferocytosis. - Source: PubMed
Publication date: 2026/04/01
Zhang HongtaoZhao ZhenXu KuiJi ZhenweiDong ChuanLong HuaNiu Shun - An ongoing debate exists on the relationship between fibrinogen levels, urinary albumin excretion (UAE), and pancreatic ductal adenocarcinoma (PDAC), as demonstrated by clinical data of patients with benign and malignant pancreatic tumors. - Source: PubMed
Publication date: 2026/03/17
Wu QianSun MengqingLin YanLin ShujinLin TingHan XiaoHan Xianlin - Non-alcoholic fatty liver disease (NAFLD) is the leading chronic liver disease globally, characterized by steatosis, inflammation, and hepatocyte injury. While the Flavin-containing monooxygenase 3 (FMO3)-trimethylamine N-oxide (TMAO) axis is a known driver of atherosclerosis, its role in NAFLD progression remains unclear. Here, we report that FMO3 is significantly upregulated in the livers of choline-deficient, high-fat diet (CDA-HFD)-induced NAFLD mice, as revealed by transcriptomic profiling and validation. Mechanistically, FMO3 overexpression exacerbated lipid accumulation and inflammatory cytokine release in vitro, while its metabolite TMAO directly aggravated hepatic steatosis and inflammation in vivo. Notably, the natural compound 3,3'-diindolylmethane (DIM) significantly attenuated NAFLD phenotypes, including serum ALT/AST levels and hepatic lipid content; however, these protective effects were reversed by exogenous TMAO supplementation. These findings identify the FMO3-TMAO axis as a critical target for regulating lipid homeostasis and inflammation, suggesting DIM as a promising therapeutic candidate for NAFLD intervention. - Source: PubMed
Publication date: 2026/03/18
Chen RunshengLiu HuaYang TinfengJiang ZhonghaoHe ZeyuZhang XinpengQian BaolinFu Wenguang - Indigo is an important blue pigment widely used in textile, food, and pharmaceutical industries. Currently, most of indigo was produced via chemical synthesis, which led to pollution to the environment and potential health hazards to consumers. Thus, biological synthesis of indigo attracts increasing attention. Flavin-containing monooxygenase (FMO) is an important enzyme for production of indigo from indole, however, only five indigo-producing FMOs have been identified. In this study, a novel indigo-producing FMO from Pseudomonas guineae was successfully screened from seven candidates. The recombinant enzyme was comprehensively studied regarding its expression, purification, and identification. The purified enzyme had two absorbance peaks at 360 and 442 nm, indicating the binding of cofactors. It showed the highest activity at pH 8.0 and 20 °C. The K, V, k, and k/K were 2.5 mM, 2.9 × 10 mM/min, 0.027 s, and 0.011 mM s, respectively. The in vivo indigo production of P. guineae FMO was evaluated by metabolically engineered E. coli BL21(DE3). After deleting the competitive genes, strengthening the tryptophan biosynthetic pathway, and optimizing indole transportation, indigo was effectively produced with a titer of 260 mg/L by shake-flask cultivation. - Source: PubMed
Publication date: 2026/02/20
Hao ZhebinZhang YuleiZhang WenliZhu YingyingMu Wanmeng - Intellectual disability (ID) is a neurodevelopmental disorder, characterized by congenital cognitive and adaptive behavioral issues. We studied multiple patients with ID born to consanguineous parents. Exome sequencing was completed for selected patients and the data were filtered using an allele frequency of less than 0.01. All exonic and splice-site variants were considered. Segregation analyses were performed using allele-specific PCR and Sanger sequencing. Expression analyses of candidate genes were determined after cDNA synthesis from the mouse brain. Clinical evaluations revealed that the patients in the four families exhibited different degrees of cognitive impairments. Patients in two families had no other phenotypes while those from the other two families also manifested disorders such as epilepsy. In family PKID01, a known homozygous missense variant of UFSP2 was found to segregate with the phenotype. We also identified four biallelic novel variants including missense, frameshift, and nonsense variants in ATP13A2, QPCTL, WDR62 and FMO4 in the affected patients from three families. Among these, the QPCTL variant pinpoints a new candidate gene for ID. This study expands the genetic etiology of ID. Intrafamilial genetic heterogeneity underscored the difficulties of molecular characterization of ID in even small nuclear consanguineous families. This research yielded only the second family in literature with a homozygous FMO4 variant, strengthening its candidature with ID. - Source: PubMed
Publication date: 2026/02/19
Butt Amina IftikharBazai Fariya KhanKakar KaleemullahDaud ShakeelaSeo Go HunAhmad JamilNaz Sadaf