Ask about this productRelated genes to: MAGEA1 antibody
- Gene:
- MAGEA1 NIH gene
- Name:
- MAGE family member A1
- Previous symbol:
- MAGE1
- Synonyms:
- MGC9326, CT1.1
- Chromosome:
- Xq28
- Locus Type:
- gene with protein product
- Date approved:
- 1994-04-04
- Date modifiied:
- 2017-04-21
Related products to: MAGEA1 antibody
Related articles to: MAGEA1 antibody
- The endosome plays a crucial role in tumor cell material transport, signal regulation, and tumor immune microenvironment modeling, but the molecular characteristics, subtyping significance, and prognostic value of endosome-related genes (ERGs) in colorectal cancer (CRC) have not been systematically elucidated. This study aims to analyze the molecular heterogeneity of CRC from the perspective of ERGs and evaluate ERGs' clinical and therapeutic significance. - Source: PubMed
Publication date: 2026/02/26
Huang XiaoYang Jie - cGAS-STING signaling can promote antitumor immunity, and tumor cell STING is suppressed in a variety of cancer subtypes that resist immune checkpoint blockade. Although STING agonists have failed clinical trials, precision approaches targeting restoration of tumor cell STING expression have yet to be explored. Here, we report that head and neck squamous cell cancer (HNSCC) exhibits a mechanism of STING suppression related to upregulation of protein tyrosine phosphatase non-receptor (PTPN) type 2 (PTPN2) that is also evident in other cancers. PTPN2 inhibition (PTPN2i) increases HNSCC tumor cell STING by restoring IFNγ-STAT1-mediated induction of STING mRNA. This restores sensitivity to STING agonism and natural killer cell activation, suppressing tumor growth in an immune cell-dependent manner in anti-PD-1 refractory syngeneic HNSCC mouse tumor models in female mice. Together, these findings demonstrate that PTPN2i can unleash STING agonist response, providing a rationale for the evaluation of this therapeutic combination in HNSCC and potentially other cancer types. - Source: PubMed
Publication date: 2026/05/02
Li ZehuaFu CongSehgal KartikEgloff Ann MarieThai Tran CMonge Omar AvilaChuong Cun LanSenent YaizaLineberry Maia SheaEschle Benjamin KHaratani KojiIvanova Elena VCampisi MarcoMahadevan Navin RQuadarella John DGedeon Patrick CSchoenfeld Jonathan DKono MichihisaFahey Caroline GChayawatto ChayapatouNgo KennethPaweletz Cloud PGokhale Prafulla CManguso Robert TUppaluri RavindraBarbie David A - Cryptorchidism is caused by a combination of environmental and genetic variables. This study aimed to identify cryptorchidism-associated susceptibility genes through bioinformatics approaches and validate their dynamic expression patterns in rat models, with the exploration of upstream transcriptional factor (TF) regulatory networks. - Source: PubMed
Publication date: 2026/03/17
Chen JianxunShen DanKong JianZhang YouboGe WenliangXian Hua - MAGE family member A1 (MAGEA1), a cancer‑testis antigen (CTA), is aberrantly expressed in several malignancies such as lung and liver cancers. However, its role in cervical cancer remains to be elucidated. The present study investigated the functional significance and therapeutic potential of MAGEA1 in cervical cancer using lentiviral short hairpin RNA‑mediated knockdown, a series of functional assays, RNA sequencing (RNA‑seq), and nude mouse xenograft models. It was found that MAGEA1 was upregulated in cervical cancer cells and its knockdown substantially suppressed cell proliferation, migration, invasion, and tumor growth. RNA‑seq analysis further revealed that MAGEA1 silencing altered pathways related to apoptosis, DNA repair, and metabolism. Moreover, MAGEA1 knockdown enhanced chemosensitivity, indicating a potential role in mediating drug resistance. Collectively, the findings identified MAGEA1 as a key oncogenic driver in cervical cancer and highlighted its promise as both a prognostic biomarker and a therapeutic target, offering novel avenues for personalized treatment strategies in cervical cancer. - Source: PubMed
Publication date: 2026/03/13
Kim AyoungKim JinaKwak WooriMo KyuminChoe SoohyunJeon MinyeongLee JisunYun Jun-WonYoon Hyunho - Hepatocellular carcinoma (HCC) accounts for approximately 90% of all primary liver cancers resulting in approximately 830,000 deaths in 2020, making HCC the sixth most common cancer globally. Several members of the Melanoma Antigen Gene (MAGE) family, such as MAGE-A1 and A3 genes of the MAGE I-A subfamily, are abnormally expressed in a variety of cancers including melanomas, colorectal cancer, non-small cell lung cancer, gliomas, HCC, prostate, and breast cancers. In addition, they have been linked to tumor stemness and, therefore, may predict therapeutic response and prognosis. - Source: PubMed
Publication date: 2026/01/22
Elgamal HodaElhammady DinaEl-Khair Salwa M AboEl-Badrawy AdelSamir AmrFarid KhaledEl Alfy Hatem