Ask about this productRelated genes to: ANKRD9 antibody
- Gene:
- ANKRD9 NIH gene
- Name:
- ankyrin repeat domain 9
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 14q32.31
- Locus Type:
- gene with protein product
- Date approved:
- 2002-12-18
- Date modifiied:
- 2015-10-15
Related products to: ANKRD9 antibody
Related articles to: ANKRD9 antibody
- Research shows that patients with viral pneumonia complicated by diabetes have a worse prognosis and higher mortality. Our study aimed to assess the effect of diabetes on respiratory tract microbes and the transcriptome in patients with viral pneumonia. We included 76 subjects from China-Japan Friendship Hospital, including 16 healthy people, 17 patients with viral pneumonia and diabetes (VD), and 43 patients with viral pneumonia without diabetes (VP). We collected their sputum samples for both metagenomic and 16S rRNA sequencing and collected blood samples for RNA sequencing. In transcriptome analysis, the VD group downregulated the expression of PTCH1 and upregulated the expression of ANK1, RBM38, BPGM, CRYM, TAL1, and HBD. The differential pathways are mainly reflected in the formation, development, and maintenance of red blood cells, the activity of immunoglobulins, and the membrane transport and transportation of substances. There is a significant difference in microbial diversity between the two groups. Both analysis methods demonstrate a significant increase in the abundance of , and in the VP group. The host genes AGAP1, RNF182, and ANKRD9 are particularly closely associated with microorganisms. Our results suggest that diabetes may inhibit the expression of genes related to immune regulation, energy metabolism, and oxygen utilization in patients with viral pneumonia. Meanwhile, we predict that VD may be associated with a decrease in microbial diversity and a decline in microbial functions in cellular processes, environmental adaptation, metabolism, and genetic activity. These abnormalities can worsen the course of viral pneumonia and affect the prognosis of patients. - Source: PubMed
Publication date: 2026/04/06
Huang ChangruiFeng QinqiYu BangZou HaoCai YashiLiu JianLi DeminZhang HongchunZou Xiaohui - Dietary fat absorption is among the most energy-demanding processes of nutrient uptake. Fatty acid activation, triglyceride synthesis, and the trafficking of chylomicrons through the secretory pathway - all require ATP. How enterocytes accommodate the surge in ATP consumption following fat uptake is unclear. We show that the purine biosynthesis/salvage pathway supplies necessary ATP and that Ankyrin Repeat Domain 9 (ANKRD9) couples ATP synthesis and lipoprotein trafficking. Ankrd9 regulates enzymes within the purine biosynthesis pathway to increase ATP synthesis and facilitate Golgi dynamics. Intracellular localization of ANKRD9 is lipid and ATP-dependent. Inactivation of Ankrd9 in mice reduces intestinal ATP despite intact mitochondrial and glycolytic function, alters Golgi morphology, delays ApoB/chylomicron trafficking, and causes lipid accumulation in enterocytes, along with a lean body phenotype. Taken together, the results reveal a previously unrecognized mechanism that regulates lipid absorption in enterocytes and identify ANKRD9 as a central component of this mechanism. - Source: PubMed
Publication date: 2026/03/13
Wang YuChen LiMa YingzeZhou MingqiGeske AleksanderSeldin MarcusZhu JiangjiangZak Alexander MDong XinzhongCole Robert NLutsenko Svetlana - 1. This study used the Chinese local breed, Gushi chicken, as the model to investigate the ankyrin repeat domain 9 () gene. This focussed on its biological function in muscle development and regulation of inosine monophosphate (IMP), a key flavour metabolite in chicken meat.2. The dynamic expression of in breast muscle tissue was analysed using qRT-PCR. Combined with transcriptomic and metabolomic technologies, the regulatory network of in chicken primary myoblasts (CPM) was elucidated.3. The results indicated that likely affected cellular adhesion and IMP accumulation. The ELISA assays in CPM confirmed that overexpression of significantly inhibited IMP metabolism in myoblasts. This suggested this gene has a key role in the negative regulation of IMP.4. These results highlighted the critical role of in regulating the flavour metabolite IMP. This provides a potential molecular target and theoretical foundation for the breeding of high-quality broilers. - Source: PubMed
Publication date: 2026/03/02
Li YYuan PWu RZhai BLi HShen JChen BLi ZLi WTian YLiu XKang XWang YLi G - Skeletal muscle development is regulated by transcriptional and post-translational mechanisms. While ankyrin repeat proteins participate in post-translational modifications, their role in myogenesis remains unclear. This study identifies ankyrin repeat domain-containing protein 9 (ANKRD9) as a novel negative regulator of chicken skeletal muscle development. ANKRD9 showed dynamic expression during postnatal muscle growth and downregulated cell cycle and DNA replication-related genes. Functionally, ANKRD9 overexpression inhibited myoblast proliferation and differentiation, while its knockdown enhanced these processes. In vivo, siRNA-mediated knockdown of ANKRD9 markedly increased muscle mass and myofiber diameter in chicks. Mechanistically, ANKRD9 bound directly to inosine monophosphate dehydrogenase 2 (IMPDH2), a rate-limiting enzyme in purine synthesis, and promoted its ubiquitin-mediated degradation without affecting mRNA levels. Crucially, rescue experiments confirmed that restoring IMPDH2 expression effectively reversed the inhibitory effects of ANKRD9 on myoblast proliferation and differentiation. Thus, this study unveils a novel regulatory axis in which ANKRD9 negatively regulates skeletal myogenesis by mediating the ubiquitination of IMPDH2. This discovery not only provides new insights into the post-translational regulatory network governing muscle development but also offers a potential target for genetic improvement of meat yield in poultry. - Source: PubMed
Publication date: 2026/02/11
Li YuanfangYuan PengtaoWang JingLi ShuaihaoZhai BinLi HongtaiLi ZhileiWang LanyaGuo YujieWang WeiZhang YanhuaZhu ShuangliLiu YingyingLi ZhuanjianTian YadongKang XiangtaoWang YadongLi Guoxi - Behçet's disease (BD) is a chronic inflammatory vasculitis marked by immune cell abnormalities and clinical variability. The recently discovered type of programmed cell death, termed cuproptosis, appears to be involved in multiple disease mechanisms. Thus, this study aimed to elucidate the involvement of cuproptosis-related genes (CRGs) in BD. - Source: PubMed
Publication date: 2025/08/04
Chen SiNie RuiWang YanLuan HaixiaWang ChaoGui YuanZeng XiaoliYuan Hui