Ask about this productRelated genes to: TNNI3K antibody
- Gene:
- TNNI3K NIH gene
- Name:
- TNNI3 interacting kinase
- Previous symbol:
- -
- Synonyms:
- CARK
- Chromosome:
- 1p31.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-01-19
- Date modifiied:
- 2019-04-23
Related products to: TNNI3K antibody
Related articles to: TNNI3K antibody
- Dengue virus (DENV) is a mosquito-borne RNA virus that causes serious illness in humans, ranging from mild fever to severe clinical manifestations, with dengue virus type 2 (DENV-2) being the most virulent among its four serotypes. Despite extensive research, no specific antiviral therapy is currently available, making the host-directed method an appealing therapeutic approach. Evidence shows that DENV manipulates host kinase-driven phosphorylation pathways to control viral pathogenesis. Using the kinase-substrate phosphomotif approach, we predicted phosphorylation sites across the DENV proteome and their potential human kinases. The predicted kinase-substrate interactions were systematically integrated with DENV-2-induced human phosphoproteome datasets, protein-protein interactions, and experimentally-validated viral phosphosites. The therapeutic relevance of the identified host kinases was corroborated by the impact of their inhibitors on DENV-2 infection. Among the 359 potential human kinases predicted to phosphorylate DENV-2 proteins, based on human phosphoproteome and kinase-viral protein interaction analyses, CDK9 emerged as a central hub kinase. Molecular docking analyses further revealed that the host kinases CDK9, EEF2K, HASPIN, and TNNI3K form stable interactions with the viral capsid and NS5 proteins. Additionally, a conservation analysis suggested that the predicted phosphorylation sites are evolutionarily conserved across DENV-2 strains. Computational prediction tools supported the predicted kinase-substrate interactions, underscoring the role of host kinases as key regulators of DENV infection, which may act as potential therapeutic targets. This study highlights the interplay between dengue viral and host proteins, providing insights into host-directed therapeutic strategies for DENV-2 infection and their potential to address the current lack of effective antiviral interventions. - Source: PubMed
Publication date: 2026/03/17
Jabbar Ayisha AShaji VineethaAnil AkashNisar MahammadSoman SowmyaPrasad GaneshAbhinand Chandran SModi Prashant KumarMadanan Madathiparambil GopalakrishnanJayanandan AbhithajPilankatta RajendraRaju Rajesh - The severity of viral myocarditis in humans and mice is variable between individuals. Numerous observations demonstrate the influence of host genetics on disease course, but few genes have actually been identified to have such properties. In past work, mouse strains that are sensitive or resistant to severe disease were used to map the viral myocarditis susceptibility locus . Here, we demonstrate that , one of the genes within the locus, influences the severity of disease following inoculation with coxsackievirus CVB3. Compared to disease-resistant C57BL/6J wild-type mice, strain-matched knockout mice showed higher cardiac inflammation and, in particular, a greater infiltration of macrophages into the heart. Long-term damage associated with viral infection was comparable in mice of both genotypes. Use of a second mouse line engineered with a point mutation to encode a kinase-dead version of Tnni3k showed the same elevated inflammation as the full null. These results identify Tnni3k and its kinase activity as being protective in modulating the acute phase of inflammatory response to CVB3 infection in the heart. - Source: PubMed
Publication date: 2026/01/30
Tjen KelseySong RuolanWestbury Baylee CLewis Lunndon ATao GeDeLeon-Pennell Kristine YBruno Katelyn ASucov Henry M - Atrial fibrillation (AF) typically affects the elderly persons. Personalized therapy for young patients needs to be considered. - Source: PubMed
Kong Ling-CongShuang TianXu Bi-HeWang Xin-Hua - Genomic resources from Tibeto-Burman (TB)-speaking populations are underrepresented in human genome research, limiting the understanding of their evolutionary history and health-related genetic influences. We genotyped 95 individuals, including Baima and Amdo Tibetans from Jiuzhaigou on the eastern Qinghai-Xizang Plateau and Qiang from Mianyang Prefecture in Sichuan Province. These data were jointly analyzed with 1722 genomes from modern and ancient East Asian populations. Clustering patterns revealed by principal component analysis suggested that the Tibetan and Qiang populations formed three distinct genetic clines, which were supported by model-based ADMIXTURE and fineSTRUCTURE analyses, highlighting complex population histories and unique genetic clusters among the Qiang and Tibetan people. Shared genetic drift estimated via f/f-statistics revealed significant gene flow between the Qiang and Han groups, suggesting that interactions with geographically proximate Han populations likely drove genomic affinity. Comparisons among TB groups (Amdo, Baima, Ü-Tsang, and Qiang) revealed varying levels of genetic affinity with ancient populations, particularly those from the Qinghai-Xizang Plateau and Yellow River Basin. Identity-by-descent and runs of homozygosity analyses indicated the persistence of stable population structures over approximately 2700 years and revealed relative demographic similarities among culturally different Tibetan groups, characterized by smaller effective population sizes than Han groups. Twenty-five high-confidence regions under selection were identified in Tibetans through XP-EHH, PBS, and Fisher score statistics, whereas 28 regions were detected in Qiangs, most of which were first identified here. The Tibetan-specific selection signals included genes related to hypoxia adaptation (e.g., TNNI3K), whereas the Qiang populations presented selection related to skin pigmentation (e.g., SLC44A5) and alcohol metabolism. The results of functional enrichment analyses suggested that the shared and distinct adaptations among these populations involved cardiovascular, metabolic, and immune processes. Overall, our findings reveal the complex genetic structure, population history, and evolutionary adaptations of Tibetan and Qiang populations in northern Sichuan. The results emphasize the role of geographic and historical factors in shaping genetic diversity and adaptive traits, contributing to our understanding of human adaptation to high-altitude environments and UV radiation in East Asia. - Source: PubMed
Publication date: 2025/10/15
Sun QiuxiaFeng YuhangWang ZhiyongSun YuntaoLuo LintaoCheng JingBu FengxiaoLu YuLiu YanLiu ChaoYuan HuijunTang RenkuanWang MenggeHe Guanglin - Pathogenic CACNA1C variants are associated with long QT syndrome, cardiac conduction disorders (CCD), short QT or Brugada syndromes, sudden cardiac death, and rarely hypertrophic cardiomyopathy. Neonatal complete AV block (CAVB) has not been previously reported in patients with CACNA1C-mutations. We present a neonate with CAVB, severe heart failure, and non-compaction cardiomyopathy, found to have a de novo, likely pathogenic, heterozygous CACNA1C variant and heterozygous variants of uncertain significance (VUS) in TNNI3K, GATA6, and PDHK1 genes. This case expands the CACNA1C-associated phenotype to include neonatal CAVB and suggests a potential oligogenic contribution to severe neonatal cardiac disease. - Source: PubMed
Publication date: 2025/09/30
Rooney Sydney RKarolcik BrockWest ShawnFollansbee ChristopherMoulik MousumiArora Gaurav