Hand and wrist joint model, plastic PVC
- Known as:
- Hand wrist joint model, plastic PVC
- Catalog number:
- KMA0253
- Product Quantity:
- Set
- Category:
- -
- Supplier:
- Kemaj
- Gene target:
- Hand and wrist joint model plastic PVC
Related genes to: Hand and wrist joint model, plastic PVC
- Gene:
- HAND1 NIH gene
- Name:
- heart and neural crest derivatives expressed 1
- Previous symbol:
- -
- Synonyms:
- eHand, Thing1, Hxt, bHLHa27
- Chromosome:
- 5q33.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-05-17
- Date modifiied:
- 2016-10-05
- Gene:
- HAND2 NIH gene
- Name:
- heart and neural crest derivatives expressed 2
- Previous symbol:
- -
- Synonyms:
- dHand, Thing2, Hed, bHLHa26
- Chromosome:
- 4q34.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-05-17
- Date modifiied:
- 2015-08-25
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- Chronic Obstructive Pulmonary Disease (COPD) is a progressive inflammatory lung disorder influenced by environmental and genetic factors. The rs3741240 polymorphism in the gene, which encodes the anti-inflammatory protein CC16, is considered a genetic marker of COPD susceptibility. - Source: PubMed
Publication date: 2025/12/12
Sultana NasimaAdhikari HimaniGoswami Achintya MohanMondal AmaleshGanai IndranilBiswas HimaniIqbal AsifDas AratrikaMoitra SaibalPodder Sanjoy - The bHLH transcription factors HAND1 and HAND2 are expressed in partially overlapping patterns during development. Studies have established evidence for significant functional redundancy between HAND1 and HAND2. To test redundancy fully, we engineered a Hand1 allele in which we directly replaced the Hand1 exons and intron with those of Hand2. The results show that 2% of Hand1Hand2/Hand2 mice are viable and fertile. The remaining Hand1Hand2/Hand2 embryos exhibit neonatal lethality due to omphalocele accompanied by ventricular septal defects and conduction anomalies. Omphalocele can occur due to altered gut rotation. Our transcriptomic expression analysis reveals that established gene expression patterns associated with normal gut rotation are compromised. Interrogation of cardiac function in surviving Hand1Hand2/Hand2 mice reveals QRS abnormalities and cardiac morphogenic defects. These data support previous findings that HAND factors exhibit extensive functional overlap but also reveals that HAND1 protein has unique functions within the Hand1 expression domain and is required for normal embryonic development. - Source: PubMed
Publication date: 2025/10/14
Firulli Beth AFerguson Chloe Ade Gier-de Vries CorriePodicheti RamRusch Douglas BChristoffels Vincent MRubart-von der Lohe MichaelFirulli Anthony B - The process of epithelial-mesenchymal transition (EMT) is crucial in various physiological/pathological circumstances such as development, wound healing, stem cell behavior, and cancer progression. It involves the conversion of epithelial cells into a mesenchymal phenotype, which causes the cells to become highly motile. This reprogramming is initiated and controlled by various signaling pathways and governed by several key transcription factors, including Snail 1, Snail 2 (Slug), TWIST 1, TWIST2, ZEB1, ZEB2, PRRX1, GOOSECOID, E47, FOXC2, SOX4, SOX9, HAND1, and HAND2. The intracellular signaling pathways are activated/inactivated by signals received from the extracellular environment and the transcription factors are carefully regulated at the transcriptional, translational, and post-translational levels to maintain tight regulatory control of EMT. One of the most important pathways involved in this process is the transforming growth factor-β (TGFβ) family signaling pathway. This review will discuss the role of EMT in promoting epithelial cancer progression and the convergence/interplay of multiple signaling pathways and transcription factors that regulate this phenomenon. - Source: PubMed
Publication date: 2025/05/03
Ghafoor SaimaGarcia ElizabethJay Daniel JPersad Sujata - Heart and neural crest derivatives-expressed protein 1 (HAND1) and Heart and neural crest derivatives-expressed protein 2 (HAND2), members of the Twist-family of basic Helix-Loop-Helix (bHLH) proteins, act as critical transcription factors that play a key role in various developmental processes, including placental development and fetal growth during pregnancy. This review aims to explore the current understanding of HAND1 and HAND2 in pregnant maintenance and their potential implications for maternal and fetal health. We will summarize the mechanisms of action of HAND1 and HAND2 in pregnancy, their expression regulation and association with pregnancy complications such as preterm birth and preeclampsia. Furthermore, we will discuss the potential therapeutic implications of targeting HAND1 and HAND2 in pregnancy-related disorders. This review highlights the importance of HAND1 and HAND2 in pregnancy and their potential as targets for future research and therapeutic interventions of gestational disorders. - Source: PubMed
Publication date: 2024/12/24
Zhu ChongyingYang QiweiXu QiangSong YanhuaTang Chao - Cardiac development is a fine-tuned process governed by complex transcriptional networks, in which transcription factors (TFs) interact with other regulatory layers. In this chapter, we introduce the core cardiac TFs including Gata, Hand, Nkx2, Mef2, Srf, and Tbx. These factors regulate each other's expression and can also act in a combinatorial manner on their downstream targets. Their disruption leads to various cardiac phenotypes in mice, and mutations in humans have been associated with congenital heart defects. In the second part of the chapter, we discuss different levels of regulation including cis-regulatory elements, chromatin structure, and microRNAs, which can interact with transcription factors, modulate their function, or are downstream targets. Finally, examples of disturbances of the cardiac regulatory network leading to congenital heart diseases in human are provided. - Source: PubMed
Grunert MarcelDorn CorneliaRickert-Sperling Silke