RICK (C-Terminus) Peptide
- Known as:
- RICK (C-Terminus) Peptide
- Catalog number:
- 2183P
- Product Quantity:
- 0.05 mg
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- RICK (C-Terminus) Peptide
Related genes to: RICK (C-Terminus) Peptide
- Gene:
- RIPK2 NIH gene
- Name:
- receptor interacting serine/threonine kinase 2
- Previous symbol:
- -
- Synonyms:
- RICK, RIP2, CARDIAK, CARD3
- Chromosome:
- 8q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1999-05-07
- Date modifiied:
- 2016-10-05
- Gene:
- TNFRSF10B NIH gene
- Name:
- TNF receptor superfamily member 10b
- Previous symbol:
- -
- Synonyms:
- DR5, KILLER, TRICK2A, TRAIL-R2, TRICKB, CD262, TRAILR2
- Chromosome:
- 8p21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-12-04
- Date modifiied:
- 2018-01-25
Related products to: RICK (C-Terminus) Peptide
Related articles to: RICK (C-Terminus) Peptide
- Pyrazolo[4,3-]tetrazolo[1,5-][1,2,4]triazine sulfonamides (-compounds) are a relatively new class of heterocyclic compounds that exhibit a wide variety of biological actions, including anticancer properties. Here, we used caspase enzyme activity assays, flow cytometry analysis of propidium iodide (PI)-stained cells, and a DNA laddering assay to investigate the mechanisms of cell death triggered by the -compounds (, , , and ). Due to inconsistent results in caspase activity assays, we have performed a bromodeoxyuridine (BrdU) incorporation assay, colony formation assay, and gene expression profiling. The compounds' cytotoxic and pro-oxidative properties were also assessed. Additionally, computational studies were performed to demonstrate the potential of the scaffold for future drug discovery endeavors. MM-compounds exhibited strong micromolar (0.06-0.35 µM) anti-proliferative and pro-oxidative activity in two cancer cell lines (BxPC-3 and PC-3). Activation of caspase 3/7 was observed following a 24-h treatment of BxPC-3 cells with IC concentrations of , and compounds. However, no DNA fragmentation characteristics for apoptosis were observed in the flow cytometry and DNA laddering analysis. Gene expression data indicated up-regulation of BCL10, GADD45A, RIPK2, TNF, TNFRSF10B, and TNFRSF1A (TNF-R1) following treatment of cells with the compound. Moreover, in silico studies indicated AKT2 kinase as the primary target of compounds. -compounds exhibit strong cytotoxic activity with pro-oxidative, pro-apoptotic, and possibly pro-necroptotic properties that could be employed for further drug discovery approaches. - Source: PubMed
Publication date: 2023/06/30
Kciuk MateuszMarciniak BeataCelik IsmailZerroug EnfaleDubey AmitSundaraj RajamanikandanMujwar SomduttBukowski KarolMojzych MariuszKontek Renata - Periodontal ligament cells play an important role in maintaining homeostasis of periodontal tissue upon mechanical force loading caused by mastication or orthodontic force. Previous studies revealed force-driven periodontal ligament cell death via apoptosis, but the force-sensing genes assigned to the apoptotic pathway have not been fully characterized. The present study aimed to identify force-sensing genes implicated in the apoptotic pathway in periodontal ligament cells. - Source: PubMed
Publication date: 2011/07/21
Xu CHao YWei BMa JLi JHuang QZhang F