ADAMTS8
- Known as:
- ADAMTS8
- Catalog number:
- 001161A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ADAMTS8
Related genes to: ADAMTS8
- Gene:
- ADAMTS8 NIH gene
- Name:
- ADAM metallopeptidase with thrombospondin type 1 motif 8
- Previous symbol:
- -
- Synonyms:
- METH2, FLJ41712, ADAM-TS8
- Chromosome:
- 11q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 1999-08-23
- Date modifiied:
- 2016-10-05
Related products to: ADAMTS8
Related articles to: ADAMTS8
- Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare, biologically heterogeneous primary liver cancer with conflicting reported outcomes. The prognostic impact of viral hepatitis in cHCC-CCA remains unclear. Given its established influence in hepatocellular carcinoma, we evaluated whether viral etiology is associated with distinct clinical and genomic features in cHCC-CCA. - Source: PubMed
Publication date: 2026/05/18
Puttagunta NehaFriedman MatthewKhandakar BinnyBrown Timothy JGrewal Udhayvir SinghHornstein Nicholas - Acute aortic dissection (AAD) is a life-threatening emergency without established effective monitoring biomarkers. This study aimed to explore biomarkers to optimize the diagnosis of AAD. AAD related genes were screened by spatial transcriptomics experiments, and their encoded proteins were validated in aortic tissues. We measured plasma levels of candidate proteins in 302 participants (173 AAD cases, 129 controls), finding higher PTMA, ADAMTS8, and CD36 in AAD. Case-control analysis revealed that elevated levels of those proteins along with D-dimer, increased systolic blood pressure (SBP), height and smoking history were risk factors for AAD. A multi-marker score comprising D-dimer, ADAMTS8, height, SBP, and age was developed for AAD diagnosis, achieving an AUC of 0.921 (95%CI 0.889-0.952), with 77.5% sensitivity and 96.5% specificity. We further validated the diagnostic performance of the multi-marker score in an independent validation set including healthy controls and patients with chest pain. Our findings indicate that PTMA, ADAMTS8, and CD36 are potential biomarkers associated with AAD. The multi-marker score effectively discriminates AAD from both healthy controls and non-AAD acute chest pain conditions, and may serve as a rapid, cost-effective auxiliary diagnostic tool. - Source: PubMed
Publication date: 2026/05/07
Tian TingZhao LipingTian XinxinLiu FenZhao QiangLuo JunyiZhao QianLi YanhongLi XiaomeiYang Yining - In this study, we investigated the genomic basis of key body measurement and weight traits in Iraqi Awassi sheep using a multi-locus genome-wide association approach. A total of 315 yearling animals were phenotyped for body length, chest depth, heart girth, withers height, and body weight, and genotyped using the Ovine 50K SNP BeadChip. Genome-wide association analyses were performed within the BLUPmrMLM framework to improve the detection of loci with moderate-to-small effects. Significant associations were identified using an LOD-based threshold (LOD ≥ 5), followed by positional annotation of nearby genes and functional enrichment analyses to infer their potential biological relevance. Multiple genomic regions were associated with the evaluated traits. Among the most biologically plausible candidate genes were and for body length, for chest depth, and for heart girth, for body weight, and , , and for withers height. Functional enrichment analyses indicated the involvement of pathways related to integrin-mediated signaling, focal adhesion and integrin complexes, extracellular matrix organization, and post-transcriptional regulation, suggesting coordinated effects of cell-matrix interactions and gene-expression regulation on body size and conformation. Overall, these findings refine the genomic landscape underlying body weight and morphometric variation in Awassi sheep and provide a focused set of loci for future validation and possible application in marker-assisted and genomic selection programs. - Source: PubMed
Publication date: 2026/03/10
Bayraktar MervanHasan Hussein FShoshin Omer - The tumor microenvironment (TME) plays a pivotal role in the progression of gastric cancer (GC) and its response to treatment, particularly by modulating parthanatos (PA). However, the prognostic significance of TME and PA, as well as their potential roles in immunotherapy for GC, remain incompletely understood. - Source: PubMed
Publication date: 2026/02/20
Liu LeiWu MinLiu Yi - Epigenetic silencing of ADAMTS-8 has been linked to increased tumor aggressiveness and poor prognosis; however, its transcriptional regulation in cancer remains largely undefined. Here, we comprehensively investigated the transcriptional regulation of ADAMTS-8 by SP1, which is associated with poor clinical outcomes in colorectal cancer (CRC). SP1 levels showed a marked upward trend in the clinical and molecular subtypes of CRC. Functional analyses demonstrated that SP1 overexpression in SW480 cells increased proliferation and migration; conversely, it significantly suppressed the ADAMTS-1 and ADAMTS-8 expressions. Furthermore, this suppressive effect was found to be reversible with Mitramycin A. Luciferase reporter assays confirmed the transcriptional repressive effect of SP1 on ADAMTS-8 promoter activity. ChIP-qPCR and EMSA demonstrated the specific binding of SP1 to the ADAMTS-8 promoter (-56/+17), indicating a direct regulatory mechanism. Clinical analyses revealed that ADAMTS-1 is significantly reduced in CRC, and low ADAMTS-1 levels are associated with poor survival. The regulatory relationship between SP1 and ADAMTS-8 was further examined in osteosarcoma, where SP1 expression was significantly elevated relative to osteoblasts, while ADAMTS-8 was markedly suppressed. The association of high ADAMTS-8 expression with better survival in the TCGA-SARC cohort supported its tumor-suppressive role in osteosarcoma. Consistently, qRT-PCR confirmed the inhibitory effect of SP1 on ADAMTS-8 in SAOS-2 cells. Overall, our findings identify SP1 as a central negative regulator of ADAMTS-1 and ADAMTS-8, contributing to tumor progression in CRC and osteosarcoma. The SP1-ADAMTS axis represents a potentially important molecular network in cancer biology and may provide a basis for developing novel biomarkers or targeted therapeutic strategies. - Source: PubMed
Publication date: 2026/01/06
Kalfa YaseminSav Feyza NurAlper MeltemKockar Feray