MYF6
- Known as:
- MYF6
- Catalog number:
- 000447A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- MYF6
Related genes to: MYF6
- Gene:
- MYF6 NIH gene
- Name:
- myogenic factor 6
- Previous symbol:
- -
- Synonyms:
- MRF4, bHLHc4
- Chromosome:
- 12q21.31
- Locus Type:
- gene with protein product
- Date approved:
- 1990-07-03
- Date modifiied:
- 2015-12-04
Related products to: MYF6
anti-MYF6anti-MYF6anti-MYF6anti-MYF6anti-MYF6 (1H3)anti-MYF6 (1H3)anti-MYF6 (1H3) type: Primary antibodies host: Mouseanti-MYF6 (5D7)anti-MYF6 type: Primary antibodies host: MouseAntibodies: Herculin _ MYF6 HOST: Goat Clonality: pAbbHLHc4,BHLHC4,Class C basic helix-loop-helix protein 4,Homo sapiens,Human,MRF4,Muscle-specific regulatory factor 4,MYF6,Myf-6,Myogenic factor 6Bos taurus,Bovine,MRF4,Muscle-specific regulatory factor 4,MYF6,Myf-6,Myogenic factor 6Bovine myogenic factor 6 (herculin) (MYF6) ELISA kit, Species Bovine, Sample Type serum, plasmaBovine Myogenic factor 6 (MYF6) ELISA KitBovine Myogenic factor 6 (MYF6) ELISA Kit Related articles to: MYF6
- Distant hybridization combines beneficial genes from different species to create high-quality germplasm with altered phenotypes and genotypes. In our previous study, two fast-growing hybrid breams (BTBB and BBTB) were developed through a multi-step breeding strategy involving distant hybridization between blunt snout bream (Megalobrama amblycephala, 2n = 48, BSB, ♀) and topmouth culter (Culter alburnus, 2n = 48, TC, ♂), followed by two rounds of backcrossing. To elucidate the mechanisms of muscle development and rapid growth, we compared growth performance, muscle texture, antioxidant enzyme activities, and the expression of myogenic regulatory factor (MRF) genes between the hybrids and their parents. The results showed that both BBTB and BTBB had significantly greater body weight and body length than BSB (p < 0.05). Histological analysis showed that the two hybrid breams had significantly lower muscle fiber density (p < 0.05) and significantly larger muscle fiber diameter than BSB (p < 0.05). Muscle texture analysis indicated that BBTB had higher adhesiveness than BSB, whereas BTBB exhibited significantly greater springiness than BSB. Antioxidant analysis showed that, compared with BSB, MDA levels were significantly lower in BBTB and BTBB (p < 0.05), whereas CAT, SOD, and GSH levels were higher. Sequence analysis showed that the full-length cDNA sequences of myod, myog, myf5, and myf6 were highly conserved between the hybrid offspring and their parents. RT-qPCR analysis revealed that the expression levels of MRFs and mstn were relatively high in the muscle tissues of both BTBB and BSB, whereas mstn expression was lower in BTBB than in BSB, suggesting that MRFs and mstn may act coordinately in the regulation of rapid growth in BTBB. In contrast, the expression levels of MRFs and mstn in BBTB were significantly lower than those in BSB, suggesting that MRF expression may increase transiently during rapid growth and then decline. Overall, the two hybrid breams exhibited distinct molecular regulatory patterns, and their superior muscle phenotypes may be associated with muscle fiber development, enhanced antioxidant capacity, and the balance between positive myogenic regulation and mstn-mediated negative regulation. These findings indicate that BBTB and BTBB are promising germplasm resources for aquaculture breeding. - Source: PubMed
Publication date: 2026/05/08
Zhou ZhifengYang XiangqiongOuyang XingeChen XinHuang YujieChen KuoFan SiyuYu XinxinLi ShengnanTao Min - This study aimed to evaluate the protective effects of hydrolyzed extract (GBE) against dexamethasone (DEX)-induced sarcopenia in C57BL/6 mice. Muscle atrophy was induced by intraperitoneal injection of DEX (20 mg/kg/day) for 10 consecutive days (Day 3-12). GBE (100 or 200 mg/kg/day) was administered orally starting 2 days before DEX treatment and continued for 12 days (Day 1-12). GBE significantly attenuated DEX-induced reductions in body weight and muscle mass. Furthermore, GBE administration upregulated the expression of muscle regeneration-related factors, including IGF-1, mTOR, MyoD, MYF5, and MYF6, while downregulating muscle atrophy markers such as myostatin, FOXO3a, MuRF1, and MAFbx. In addition, GBE enhanced antioxidant enzyme activities and suppressed pro-inflammatory cytokines including IL-6 and TNF-α. These findings suggest that GBE may serve as a promising functional ingredient to prevent glucocorticoid-induced muscle atrophy and may offer therapeutic potential for the management of muscle wasting conditions. - Source: PubMed
Publication date: 2026/03/18
Shin Jae YoungPark Ji HyeonLim Jun HyeongCho Byoung OkKang Ju SeogJang Seon Il - Skeletal muscle function relies on uniaxially organized myofibers, whose aligned extracellular matrix provides instructive topographical cues that regulate myogenic behavior. Here, we introduce a melt electrofibrillation strategy, melt electrowriting (MEW) of poly (ε-caprolactone)/poly (vinyl acetate) blends, followed by selective polyvinyl acetate removal, to fabricate highly aligned nanofibrillar microbundle scaffolds that present collagen-like nanotopography. We first verified biocompatibility and alignment guidance using primary human skeletal muscle cells compared with 2D tissue culture polystyrene controls. We then assessed the myogenic response of human adipose-derived stem cells (hASCs) on nanofibrillar scaffolds relative to conventional MEW-printed microfibers and 2D controls. Nanofibrils supported sustained viability over 35 days and promoted pronounced cell alignment, aligned collagen type-I deposition, and enhanced myogenic differentiation. hASCs on the scaffolds formed myosin-positive, multinucleated myotube-like structures by days 28-35 and exhibited increased MYOG and MYF6 expression by qPCR. Bulk RNA sequencing (day 21) further showed that nanofibrils induce a distinct transcriptional state enriched for muscle development/differentiation and contraction-associated programs, accompanied by activation of mechanosensitive signaling and adhesion-cytoskeleton remodeling pathways (PI3K-Akt, MAPK, Wnt, Hippo, and TGF-β). Titin immunostaining revealed early sarcomere assembly, indicating progression toward maturation. Collectively, nanofibrillar scaffolds establish a programmable, muscle-mimetic fibrillar niche that strengthens topography-driven myogenesis of hASCs and supports prolonged culture, providing a versatile platform for in vitro muscle tissue engineering. - Source: PubMed
Publication date: 2026/04/08
Mussoni CamillaHeinze CorinnaRyma MatthiasJun IndongLamberger ZanAndelovic KristinaKade Juliane CStahlhut PhilippLang GregorAhmad TaufiqGroll Jürgen - Radiation esophagitis is a common adverse effect of radiotherapy for head and neck cancers, and is marked by irreversible damage and fibrosis of esophageal muscle tissue. Although mesenchymal stem cell (MSC) therapy is emerging as a promising approach for tissue regeneration, clinical translation remains challenging due to issues with cell viability and differentiation in vivo. This study evaluates the regenerative efficacy of exosomes derived from MSCs transfected with myogenic genes (MyoD, Myogenin, Myf6, referred to as Myo-MIX) using a murine model of radiation-induced esophageal fibrosis. - Source: PubMed
Publication date: 2026/04/05
Kim Min-KyungKim In GulEom So YoungKim YewonKim Jin-ASeok JungirlChung SeokKim Hye-JoungChung Eun-Jae - The PAX7::FOXO1 subtype of alveolar rhabdomyosarcoma (aRMS) is both understudied and an unmet clinical need. The biology of PAX7::FOXO1 aRMS is significantly different than PAX3::FOXO1 aRMS, presenting an opportunity to gain biological, clinical and therapeutic insights by murine genetic modeling of for comparison to the existing conditional genetic mouse model of aRMS. - Source: PubMed
Publication date: 2026/03/27
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