Pathway: Rn Retinol metabolism WP1297 74434

3, 4beta-caroteneBloodall-trans RA?Cytochrome P450 familyRE + dietary lipidsall-trans RAL9-cis RAROLREEnterocyte?11-cis RAL??13,14 dehydro RAbeta-carotene13,14 dehydro RALchylomicronLiver/other organs?11-cis ROL9-cis ROLbeta-10'-apocarotenalRE + dietary lipids9-cis RALROL=retinol; RAL=retinaldehyde, RA = retinoic acid, RE = retinyl ester, RPE = retinal pigment epithelium RPE-specificNuclear receptorsbeta-carotene11-cis binding proteinRA-binding proteinsROL?all-trans-4-oxo dehydro RARE + dietary lipidsall-trans ROL13,14 dehydro ROLRERALbeta-caroteneall-trans-4-oxo RANucleusROL-binding proteinsPPAR pathwaysAldh1a2Crabp2RxrgRdh12Rbp4Aldh1a1Sult1a1Scarb1Abcg5ARATBcmo1Npc1l1Rdh8RaraCyp26a1luteinRpe65Bcmo1Dhrs3RARbRxrbSult2b1alpha-caroteneAldh1a3MAPKScarb1Bcmo1Crabp1Rbp1Rdh5RargzeaxanthinLplVitamin D3RxraviolaxanthincryptoxanthinCyp26b1Abcg8RetsatRbp7Bcdo2LratRdh5Adh1LratlycopeneAdh4Rdh10Rdh12Rlbp1Aldh1a2Rbp2Cyp2e1beta-cryptoxanthinastaxanthinAldh1a3Cd36Aldh1a1canthaxanthin5, 16, 241, 6, 10, 18, 20...142, 7, 9, 11-13, 15...8, 17, 21, 24

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