Pathway: Hs Corticotropin-releasing hormone WP2355 79973

PRKCQPcGMPNOProinflammatory effect in leukocytesActivated inkeratinocytesthymocytesPlacentalvesselvasodilationCorticotropin-Releasing Hormone Signaling PathwayNUCYNUCyclaseCYENInhibited inmelanocytespituitary corticotrophspituitary tumor cellsRegulation of CRHmRNAGuanylateFatty acidoxidationNUAdenylateNUCYENDesensitizationIncreased gap junctionsNeuroprotectionVEGF releasein mast cellsFASL releasein PC12 cellsCYPMRecycling of receptorsApoptosis inMicroglial cellsHippocampal neuronsProstate cancer cellsNUCYDehydroepiandrosterone sulfate and cortisol productionKeratinocytedifferentiationand proliferationCell survivalNUCYNUPMCYNeuronalsurvivalInhibits Cell proliferationPRKATRIM28NOS3NCOA2NR4A1FOSL2JUNCACNA1HSP1FOSACACAPRKAA2RHOACRHFOSL1CRHBPJUNDFOSBNR4A1IL18JUNBTLR4PTK2IL8S80T172PPRKCIPPRKCDPHSD3B1TCF4TFAP2ACTNNB1ACTH productionMAPK3T202T204IL2KRT1MAPK9Y185T183NR4A2CRHR2MAPK1CRHY185Y187SP1CYP11A1HSP90AA1IVLCRHR1S386NR4A1S412S301TFAP2ACRHCRHR1EPACCTNNB1KRT14Enzyme complexTranslocation DeubiquitinationActivationInhibitionAcetylationNegative regulation of gene expressionLEGENDLeads to through unknown mechanismPhosphorylationProtein-protein interactionTransportUbiquitinationDephosphorylationInduced catalysisAuto catalysisSumoylationPositive regulation of gene expressionReceptorLigandProteinDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageRELAPRKCBPPRKCAPGNAQCREB1S133PRKAcAMPGNB5GNB3GNB2GNB1ADRBK2GNA11GNAO1GNASGNAI2GNAI1DAGIP3PIP2MAP2K1BRAFRAP1BPLCB3PLCG2S537PPLCG1PGSK3BS9PARP1PCCASP9PCCASP3PCCASP12PCMAPK8Y185T183MAP3K5PERNPCYP21A2CYP17A1STARCYP11B1CYP11A1CAMK2AHSD3B2GRK6ADRBK2ECE1NFKBIAPCGJA1CRHR2ARRB1SULT2A1ADRBK2CRHARRB2RELABCL2PI3KAKT1S473POMCNR4A2FOSCalciumPMCYARRB1ARRB2PMCYECE1CRHCRHR1CRHR2CRHCRHR1T399CRHCyclaseGNAZELK1TBX19FOSG-gammaInhibits Progesterone synthesis in Placental trophoblastspathwayDegradationand dissociationof NFKBsNFKB1NFKB1NFKB1MAPK14T180Y182NR4A1AP-1 complexClathrin and arrestin mediated endocytosisENPMPro-inflammatorycytokine productionCRHCRHBPProtein

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