Pathway: Hs Allograft Rejection WP2328 84648

2-6, 8, 9C5 CONVERTASEFibrosisApoptosisMacrophageperoxisomeTregLegendnucleusCLASSICAL COMPLEMENTPATHWAYC3 CONVERTASENon-Immune PhenomenaACUTE AMR REJECTIONNEUTROPHILS/MACRO/NKMEMBRANE ATTACK COMPLEX ACTIVATIONIgGAbs toY-CVFCHRONIC AMR REJECTION?Calcineurin Inhibitor NephrotoxicityALTERNATIVE COMPLEMENTPATHWAYTT: Therapeutic Target (decrease)Donor CellsTT: Therapeutic Target (increase)C1 COMPLEXIgM?PlasmacellATTACKENDOTHELIALCELLSCD 8+ T cellDonor CellMaturationTH2cellTH17Naive T cellTTTH1cellDirectDirect Donor APCIndirectRecipient APCCXCL11IL8CCL19CXCL9TUBA1BC4AC3C5BHMT2IL1APDGFRACXCL12HARSVIMCSNK2A2GABPAPECRBHMT2CXCR5MICAC5CCL21CXCL11GDNFAGTR1GNLYIFNGCXCL9ABCB1LRRK2STAT1IL21CXCL9CSNK2A2PDGFRACCL19CXCL11IFNGVEGFAHARSCOL5GDNFIL21GDNFIL2CXCL13C3CCL211CD28IFNGIL13IL4IL12BHLA-Bko:K10785Nitric oxideIL10Cell adhesion molecules (CAMs)HLA-GHLA-FPRF1HLA-CIL2IL21FOXP3IL22HLA-EGZMBTGFB1IL10TNFko:K10784IL5IL17AIL4IL12AIFNGIL5CD 4+ T cellIndirectCD40LGB cellCD40CD 8+ T cellFASHLA-AFASLGBOLA class I histocompatibility antigenko:K06856Allograft RejectionBelataceptCTLA4C2C9C8bC6Daf1C1qaC1qbC4aC7C8aC4bC1qcTTC3Daf1ECULIZUMABCD40LGCD40CD 8+ T cellCD 8+ T cellCD 8+ T cellTH1cellCD 8+ T cellCD 8+ T cellCD 8+ T cellNaive T cellNaive T cellNaive T cellTH1cellTH1cellCD 4+ T cellCD 4+ T cellCD 4+ T cellTregTregTregTH17TH17TH17PlasmacellPlasmacellPlasmacellB cellB cellB cellTH2cellTH2cellCASP8CASP7CASP3CASP9TH2cellHLAIgG3IgG1NONHLAAntibodiesPRKCZTacrolimusCiclosporinDaclizumabBasiliximabPrednisoneMethylprednisoloneSirolimusIL2RAIL1BDonor ParenchymalGraft CellsMHCIMHCIIHLA-DRB3HLA-DRAHLA-DMBHLA-DRB1HLA-DQA2HLA-DPA1HLA-DOBHLA-DRB4HLA-DOAHLA-DQA1HLA-DQB1HLA-DRB5CD80HLA-DMAHLA-DPB1MHCIICD28TCRTCRDirect Donor APCCD80HLA-EHLA-GHLA-FHLA-BHLA-CHLA-ACD86MHCIMHCIITTTTTTGZMBPRF1TTTTTTFenofibrate7Fenofibrate7TTTTTTTT??

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