Mouse IgG3 (Fc) (min X Hu, Bov, Rb Sr Prot), APC

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972 USD
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known as: Mouse IgG3 (Fc) (min X Hu, Bov, Rb Sr Prot), APC
Catalog number: genta-JGM135209
Product Quantity: 0.3 ml.
Supplier: Accu

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Gene target: igg3 fc min x hu bov rb sr prot apc

Related genes to: Mouse IgG3 (Fc) (min X Hu, Bov, Rb Sr Prot), APC

Symbol : Apc NIH gene
chromosome : Un
description : adenomatous polyposis coli
type of gene : protein-coding
Other designations : Adenomatous polyposis coli protein
Modification date : 2016-02-20
Symbol : min NIH gene
Synonyms : mi
dbXrefs : FLYBASE:FBgn0002747
chromosome : 2
map location : 56E-56E|2-90 cM
description : mini
type of gene : unknown
Modification date : 2016-05-09
Symbol : Prot NIH gene
dbXrefs : MGI:MGI:107578
chromosome : 18
description : proline transporter
type of gene : protein-coding
Symbol from nomenclature authority : Prot
Full name from nomenclature authority : proline transporter
Nomenclature status : O
Modification date : 2016-07-02

Related Pathways to: Mouse IgG3 (Fc) (min X Hu, Bov, Rb Sr Prot), APC

Gene about :IgG3
Pathway :Hs Allograft Rejection
Gene about :APC
Pathway :Sc Cell Cycle and Cell Division

Related product to: Mouse IgG3 (Fc) (min X Hu, Bov, Rb Sr Prot), APC

Related Articles about: Mouse IgG3 (Fc) (min X Hu, Bov, Rb Sr Prot), APC

Mutational Heterogeneity in APC and KRAS Arises at the Crypt level and Leads to Polyclonality in Early Colorectal Tumorigenesis.

Purpose:  The majority of genomic alterations causing intratumoral heterogeneity (ITH) in colorectal cancer (CRC) are thought to arise during early stages of carcinogenesis as a burst but only after truncal mutations in APC have expanded a single founder clone. We have investigated if the initial source of ITH is consequent to multiple independent lineages derived from different crypts harboring distinct truncal APC and driver KRAS mutations, thus challenging the prevailing monoclonal monocryptal model.

Experimental design: High-depth next-generation sequencing and SNP arrays were performed in whole lesion extracts of 37 FAP colorectal adenomas. Also, ultra-sensitive genotyping of hotspot mutations of APC and KRAS was performed using nanofluidic PCRs in matched bulk biopsies (n=59) and crypts (n=591) from 18 adenomas and 7 carcinomas and adjacent normal tissues.

Results: Multiple co-occurring truncal APC and driver KRAS alterations were uncovered in whole lesion extracts from adenomas and subsequently confirmed to belong to multiple clones. Ultra-sensitive genotyping of bulk biopsies and crypts revealed novel undetected APC mutations that were prominent among carcinomas, whereas abundant wild-type APC crypts were detected in adenomas. KRAS mutational heterogeneity within crypts was evident in both adenomas and carcinomas with a higher degree of concordance between biopsy and crypt genotyping in carcinomas. Non-random heterogeneity among crypts was also observed.

Conclusions: The striking degree of non-random intercrypt heterogeneity in truncal and driver gene mutations observed in adenomas and carcinomas is consistent with a polycryptal model derived from multiple independent initiation linages as the source of early ITH in colorectal carcinogenesis. - Source :PubMed

Reliability, validity, and norms of the 2-min walk test in children with and without neuromuscular disorders aged 6-12.

The 2-min walk test may be more appropriate functional exercise test for young children. This study aimed to examine the 2-min walk test's reliability; validity; and minimal clinically important difference; and to establish norms for children aged 6-12. - Source :PubMed

Dynamics of dissolved nutrients in the aquaculture shrimp ponds of the Min River estuary, China: Concentrations, fluxes and environmental loads.

Dissolved inorganic nutrients (NO2(-)-N, NO3(-)-N, NH4(+)-N, and PO4(3-)-P) play a critical role in the effective management of water quality and prevention of fish and shrimp diseases in aquaculture systems. In this study, dissolved inorganic nutrient concentrations in the water column and sediment porewater, and the fluxes across the sediment-water interface (SWI) were investigated in three intensive shrimp ponds with zero water exchange to examine nutrient cycling during the different growth stages of shrimps. Distinct changes in the dissolved inorganic nutrient concentrations in both the water column and sediment porewater were observed among the three growth stages. Average NO2(-)-N, NO3(-)-N, NH4(+)-N, and PO4(3-)-P concentrations in the sediment porewater were 3.53, 2.81, 29.68, and 6.44 times higher, respectively, than those in the water column over the study period, indicating that the pond sediment acted as a net source of nutrients to the water column. This was further supported by the net release of nutrients from the sediments to the water column observed during the incubation experiment. Nutrient fluxes were dominated by NH4(+)-N, while NOx(-)-N (NO2(-)-N and NO3(-)-N) and PO4(3-)-P fluxes remained low. The high rates of NH4(+)-N release from the sediment highlight the need of taking into account the biogeochemical role of sediments in mitigating the problem of water quality degradation in coastal shrimp ponds. Based on a total water surface area of mariculture ponds and a total mariculture production of 2.57×10(6)ha and 2.30×10(9)kg, respectively, we estimated conservatively that approximately 4.77×10(4)tons of total nitrogen and 3.75×10(3)tons of total phosphorus are being discharged annually from the mariculture ponds into the adjacent coastal zones across China. Results demonstrated the importance of aquaculture pond effluent as a major contributor of water pollution in the coastal areas of China, and called for actions to properly treat these effluents in alleviating the eutrophication problem in the Chinese coastal zones. - Source :PubMed

Decision-to-delivery interval: Is 30 min the magic time? What is the evidence? Does it work?

Emergency caesarean section is required when delivery can reduce the risk to the life of the mother or foetus. When a caesarean section is indicated for foetal compromise, a decision-to-delivery interval of 30 min (or less) has been suggested as the ideal time frame within which an obstetric team should achieve delivery. In theory, a short decision-to-delivery interval may minimise intra-uterine hypoxia and improve neonatal outcome. Current medical evidence does not support this time frame. There are certain indications for caesarean section that necessitate a much shorter decision-to-delivery interval, but evidence suggests that the majority of neonates may be safely delivered within a longer interval of time. Current tools available for the diagnosis of foetal distress are imperfect, and the concept of foetal distress is poorly defined. Future research should focus on finding accurate means of diagnosing foetal distress in labouring women and establishing universally agreed evidence-based decision-to-delivery targets without compromising maternal or foetal safety. - Source :PubMed

Heart Rate Recovery After 6-min Walking Test Predicts Acute Exacerbation in COPD.

Abnormalities of autonomic function have been reported in patients with chronic obstructive pulmonary disease (COPD). Our objectives were to identify determinants of abnormal heart rate recovery at 1 min (HRR1) following completion of the 6-min walk test (6MWT) in COPD and to establish whether abnormal HRR1 predicts acute exacerbations (AECOPD). - Source :PubMed

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