Mouse IgG2a, Control, FITC + Mouse IgG2a, RPE, dual label

542 EUR
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known as: Mouse IgG2a, Control, FITC + Mouse IgG2a, RPE, dual label
Catalog number: genta-YSRTDC013
Product Quantity: vial
Supplier: Accu

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Gene target: igg2a rpe

Related genes to: Mouse IgG2a, Control, FITC + Mouse IgG2a, RPE, dual label

Symbol : rpe NIH gene
LocusTag : NGR_c15200
description : Rpe; ribulose-phosphate 3-epimerase
type of gene : protein-coding
Modification date : 2014-10-31

Related Pathways to: Mouse IgG2a, Control, FITC + Mouse IgG2a, RPE, dual label

Gene about :Label
Pathway :Mm Hfe effect on hepcidin production
Gene about :Rpe
Pathway :Rn Relationship between glutathione and NADPH
Gene about :Control
Pathway :Rn Wnt Signaling Pathway NetPath

Related product to: Mouse IgG2a, Control, FITC + Mouse IgG2a, RPE, dual label

Related Articles about: Mouse IgG2a, Control, FITC + Mouse IgG2a, RPE, dual label

Effect of Endothelin-1 on proliferation, migration and fibrogenic gene expression in human RPE cells.

The pathology of the fibrotic proliferative vitreoretinopathy (PVR) membrane represents an excessive wound healing response characterised by cells' proliferation, migration and secretion of extracellular matrix molecules (ECMs). Retinal pigment epithelial (RPE) cells are a major cellular component of the fibrotic membrane. Endothelin-1 (ET-1) has been reported to be involved in the development of PVR in vivo research. However, little is known about the role of ET-1 in RPE cells in vitro. In the present study, we investigated the role of ET-1 in the proliferation, migration and secretion of ECMs (such as type I collagen and fibronectin) in RPE cells in vitro. Our results illustrated that ET-1 promoted the proliferation, migration and secretion of ECMs through the protein kinase B (Akt) and extracellular signal-regulated kinase (Erk) signaling pathways in RPE cells in vitro. These findings strongly suggested that ET-1 may play a vital role in the development of PVR. - Source :PubMed

Complement-Mediated Regulation of Apolipoprotein E in Cultured Human RPE Cells.

Complement activation is implicated in the pathogenesis of age-related macular degeneration (AMD). Apolipoprotein E (ApoE) and complement activation products such as membrane attack complex (MAC) are present in eyes of individuals with AMD. Herein, we investigated the effect of complement activation on induction of ApoE accumulation in human retinal pigment epithelial (RPE) cells. - Source :PubMed

Long-Term Efficacy of GMP Grade Xeno-Free hESC-Derived RPE Cells Following Transplantation.

Retinal pigment epithelium (RPE) dysfunction underlies the retinal degenerative process in age-related macular degeneration (AMD), and thus RPE cell replacement provides an optimal treatment target. We characterized longitudinally the efficacy of RPE cells derived under xeno-free conditions from clinical and xeno-free grade human embryonic stem cells (OpRegen) following transplantation into the subretinal space of Royal College of Surgeons (RCS) rats. - Source :PubMed

Semaphorin4D-PlexinB1 Signaling Attenuates Photoreceptor Outer Segment Phagocytosis by Reducing Rac1 Activity of RPE Cells.

Semaphorins form a family of secreted and membrane-bound molecules that were identified originally as axonal guidance factors during neuronal development. Given their wide distribution in many including mature tissues, semaphorin 4D (sema4D) and its main functional receptor plexin B1 (plxnB1) are expected to fulfill additional functions that remain to be uncovered. A main characteristic of the plexin receptor family is its ability to reorganize the cytoskeleton. PlxnB1 specifically may directly interact with Rho family GTPases to regulate F-actin driven pathways in cells in culture. Diurnal clearance phagocytosis by the retinal pigment epithelium (RPE) of photoreceptor outer segment fragments (POS) is critical for photoreceptor function and longevity. In this process, rearrangement of RPE cytoskeletal F-actin via activation of the Rho family GTPase Rac1 is essential for POS internalization. Here, we show a novel role in POS phagocytosis by RPE cells in culture and in vivo for plexin B1 and its ligand sema4D. Exogenous sema4D abolishes POS internalization (but not binding) by differentiated RPE cells in culture by decreasing the GTP load of Rac1. In the rat eye, sema4D localizes to retinal photoreceptors, while PlxnB1 is expressed by neighboring RPE cells. At the peak of diurnal retinal phagocytosis after light onset, plxnB1 phosphorylation and sema4D levels are reduced in wild-type rat retina in situ but not in mutant RCS rat retina in which the RPE lacks phagocytic activity. Finally, increased POS phagosome content after light onset is observed in the RPE in situ of mice with either plxnB1 or sema4D gene deletion. Altogether, our results demonstrate a novel physiological function for sema4D/plxnB1 signaling in RPE phagocytosis serving as attenuating brake prior to light onset whose release enables the diurnal phagocytic burst. - Source :PubMed

Monitoring Resistance Exercise Intensity via RPE in Previously Untrained Patients with Prostate Cancer undergoing Androgen Deprivation Therapy.

Exercise has been shown to be safe and effective for prostate cancer (PrCa) patients. The monitoring of resistance exercise (RE) intensity is an emerging area of interest in RE prescription. Rating of perceived exertion (RPE) is one of the most commonly used methods, but has not yet been validated in this population. Thus, the purpose of this study was to examine the relationship between RPE and RE intensity in PrCa. Data for this study were abstracted from baseline upper and lower body strength assessments from two previous trials (IDEA-P; Livestrong) in our laboratory investigating functional outcomes in PrCa patients undergoing androgen deprivation therapy (ADT). A total of 75 participants from both trials were included in this study. RPE's corresponding to 50%, 70% and 90% 1RM were extracted from the results of participants' upper and lower body 1RM strength tests. The changes in RPE across increasing intensities were assessed using separate univariate analysis of variance (ANOVA). For each ANOVA, RPE was used as the dependent variable and intensity (50%, 70%, 90%) used as the fixed factor. A univariate ANOVA revealed a significant difference (p<0.05) among the RPE values for each intensity for both upper and lower body lifts. The results of our analyses suggest that RPE values rise linearly in response to increases in exercise intensity. Our study supports the concept that RPE may be a practical training tool to accurately estimate RE intensity in PrCa survivors undergoing ADT. Practitioners may consider employing RPE to monitor and adjust RE intensity in this population. - Source :PubMed

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