Mouse IgG2a (min X Ck,Rb,Gt,Hrs,Sw,Bab,Hu IgG, Hu IgM), Clone LOMG2a2, Rat Mab anti_

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4319 EUR
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known as: Mouse IgG2a (min X Ck,Rb,Gt,Hrs,Sw,Bab,Hu IgG, Hu IgM), Clone LOMG2a2, Rat Mab anti_
Catalog number: genta-YULLOMG2a2-10
Product Quantity: 10 ml.
Category:
Supplier: Accu

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Gene target: igg2a min x ck rb gt hrs sw bab hu clone lomg2a2 mab

Related genes to: Mouse IgG2a (min X Ck,Rb,Gt,Hrs,Sw,Bab,Hu IgG, Hu IgM), Clone LOMG2a2, Rat Mab anti_

Symbol : Hrs NIH gene
LocusTag : Dmel_CG2903
Synonyms : CG2903|DmHRS|DmelCG2903|HRS|HRS-2|Vps27|dHrs|hrs|l(2)23AB5|l(2)23Ad|l(2)23Ad(Hrs)|vps27
dbXrefs : FLYBASE:FBgn0031450
chromosome : 2L
map location : 23A3-23A3
description : Hepatocyte growth factor regulated tyrosine kinase substrate
type of gene : protein-coding
Symbol from nomenclature authority : Hrs
Full name from nomenclature authority : Hepatocyte growth factor regulated tyrosine kinase substrate
Nomenclature status : O
Other designations : CG2903-PA|CG2903-PB|CG2903-PC|F[[1]]F[[0]] ATPase|HGF-regulated tyrosine kinase substrate|Hrs-PA|Hrs-PB|Hrs-PC|hepatocyte growth factor regulated tyrosine kinase|hepatocyte growth factor regulated tyrosine kinase substrate|hepatocyte growth factor-re
Modification date : 2016-06-11
Symbol : IGG NIH gene
dbXrefs : AnimalQTLdb:17939
chromosome : 2
map location : 2 0.2 cM
description : Immunoglobulin G level
type of gene : unknown
Modification date : 2015-01-24
Symbol : min NIH gene
Synonyms : mi
dbXrefs : FLYBASE:FBgn0002747
chromosome : 2
map location : 56E-56E|2-90 cM
description : mini
type of gene : unknown
Modification date : 2016-05-09

Related Pathways to: Mouse IgG2a (min X Ck,Rb,Gt,Hrs,Sw,Bab,Hu IgG, Hu IgM), Clone LOMG2a2, Rat Mab anti_

Gene about :IgG
Pathway :Mm Microglia Pathogen Phagocytosis Pathway
IgG

Related product to: Mouse IgG2a (min X Ck,Rb,Gt,Hrs,Sw,Bab,Hu IgG, Hu IgM), Clone LOMG2a2, Rat Mab anti_

Related Articles about: Mouse IgG2a (min X Ck,Rb,Gt,Hrs,Sw,Bab,Hu IgG, Hu IgM), Clone LOMG2a2, Rat Mab anti_

Post-exposure treatment of non-human primates lethally infected with Ebola virus with EBOTAb, a purified ovine IgG product.

Despite sporadic outbreaks of Ebola virus (EBOV) over the last 4 decades and the recent public health emergency in West Africa, there are still no approved vaccines or therapeutics for the treatment of acute EBOV disease (EVD). In response to the 2014 outbreak, an ovine immunoglobulin therapy was developed, termed EBOTAb. After promising results in the guinea pig model of EBOV infection, EBOTAb was tested in the cynomolgus macaque non-human primate model of lethal EBOV infection. To ensure stringent therapeutic testing conditions to replicate likely clinical usage, EBOTAb was first delivered 1, 2 or 3 days post-challenge with a lethal dose of EBOV. Results showed a protective effect of EBOTAb given post-exposurally, with survival rates decreasing with increasing time after challenge. Viremia results demonstrated that EBOTAb resulted in a decreased circulation of EBOV in the bloodstream. Additionally, assay of liver enzymes and histology analysis of local tissues identified differences between EBOTAb-treated and untreated groups. The results presented demonstrate that EBOTAb conferred protection against EBOV when given post-exposure and should be explored and developed further as a potential intervention strategy for future outbreaks, which are likely to occur. - Source :PubMed

Serum IgG4:IgG Ratio Predicts Recurrence of Patients with Hepatocellular Carcinoma after Curative Resection.

Aim: IgG4 is associated with a Th1-to-Th2 switch, which plays a vital role in metastasis, in patients with malignances; thus, we aimed to investigate its clinical significance in predicting hepatocellular carcinoma (HCC) recurrence in the present study. Methods: The correlation between serum IgG4:IgG ratio and recurrence was analyzed in a cohort of 195 patients undergoing curative resection in 2012. Another 100 patients were analyzed in a prospective independent cohort during 2012-2013 to validate the value of serum IgG4. Serum IgG4 and total IgG concentrations were measured with an automatic immune analyzer and the optimal cutoff value for serum IgG4 levels was determined by X-tile software. Results: Our data revealed that serum IgG4:IgG were significantly elevated in patients with tumor recurrence (P<0.05). A cutoff IgG:IgG4 ratio of 0.08 was set to stratify HCC patients into high (>0.08) and low (≤0.08) groups. High serum IgG4:IgG ratio correlated with significantly shorter time-to-recurrence (median 11.85 months vs. 39.20, P=0.005). Univariate and multivariate analyses demonstrated that serum IgG4:IgG ratio is an independent indicator of tumor recurrence and this retained its clinical significance even in conventional low-recurrence-risk subgroups, including patients with low α-fetoprotein and early-stage diseases. Conclusion: Our results demonstrated that elevated serum IgG4:IgG ratio is associated with poor clinical outcomes in HCC patients and therefore, and can serve as a novel prognostic predictor for HCC patients undergoing resection. Analyzing serum IgG4 would be useful to tailor individualized therapies for patients. - Source :PubMed

Reliability, validity, and norms of the 2-min walk test in children with and without neuromuscular disorders aged 6-12.

The 2-min walk test may be more appropriate functional exercise test for young children. This study aimed to examine the 2-min walk test's reliability; validity; and minimal clinically important difference; and to establish norms for children aged 6-12. - Source :PubMed

The elicitor protein AsES induces a SAR response accompanied by systemic microbursts and micro-HRs in Fragaria ananassa.

The elicitor AsES (Acremonium strictum Elicitor Subtilisin) is a 34 KDa subtilisin-like protein secreted by the opportunistic fungus Acremonium strictum. AsES activates the innate immunity and confers resistance against anthracnose and grey mold diseases in strawberry plants (Fragaria x ananassa Duch.) and the last disease also in Arabidopsis. In the present work, we show that upon AsES recognition, a cascade of defense responses is activated, including: calcium influx, biphasic oxidative burst (O2(.-) and H2O2), HR response, accumulation of autofluorescent compounds, cell wall reinforcement with callose and lignin deposition, salicylic acid accumulation, and expression of defense-related genes such as FaPR1, FaPG1, FaMYB30, FaRBOH-D, FaRBOH-F, FaCHI23 and FaFLS. All these responses occurred following a spatial and temporal program: firstly were induced in infiltrated leaflets (local acquired resistance, LAR), spreading out to lateral leaflets and later to distal untreated leaves (systemic acquired resistance, SAR). After AsES treatment, macro-HR and macro oxidative bursts were localized in infiltrated leaflets while micro-HRs and microbursts occurred later in untreated leaves, being confined to a single cell or a cluster of few epidermal cells that differentiate from the surrounding ones. The differentiated cells initiate a time dependent series of physiological and anatomical changes, evolving to idioblasts accumulating H2O2 and autofluorescent compounds that blast delivering its content unto surrounding cells. This kind of systemic cell death process in plants is described for first time in response to a single elicitor. All data presented in this study suggest that AsES has the potential to activate a wide spectrum of biochemical and molecular defense responses in F. ananassa what may explain the induced protection towards pathogens of opposite lifestyle like hemibiotrophic and necrotrophic fungi. - Source :PubMed

HLA Class Ia and Ib Polyreactive Anti-HLA-E IgG2a Monoclonal Antibodies (TFL-006 and TFL-007) Suppress Anti-HLA IgG Production by CD19+ B Cells and Proliferation of CD4+ T Cells While Upregulating Tregs.

The anti-HLA-E IgG2a mAbs, TFL-006 and TFL-007, reacted with all HLA-I antigens, similar to the therapeutic preparations of IVIg. Indeed, IVIg lost its HLA reactivity, when its HLA-E reactivity was adsorbed out. US-FDA approved IVIg to reduce antibodies in autoimmune diseases. But the mechanism underlying IVIg-mediated antibody reduction could not be ascertained due to the presence of other polyclonal antibodies. In spite of it, the cost prohibitive high or low IVIg is administered to patients waiting for donor organ and for allograft recipients for lowering antiallograft antibodies. A mAb that could mimic IVIg in lowering Abs, with defined mechanism of action, would be highly beneficial for patients. Demonstrably, the anti-HLA-E mAbs mimicked several functions of IVIg relevant to suppressing the antiallograft Abs. The mAbs suppressed activated T cells and anti-HLA antibody production by activated B cells, which were dose-wise superior to IVIg. The anti-HLA-E mAb expanded CD4+, CD25+, and Foxp(3)+ Tregs, which are known to suppress T and B cells involved in antibody production. These defined functions of the anti-HLA-E IgG2a mAbs at a level superior to IVIg encourage developing their humanized version to lower antibodies in allograft recipients, to promote graft survival, and to control autoimmune diseases. - Source :PubMed

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