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Gene target: poly adp ribose


Symbol : adp NIH gene
LocusTag : Dmel_CG5124
Synonyms : CG5124|DmelCG5124|anon-WO0196371.1|anon-WO0196371.27|anon-WO0196371.3
dbXrefs : FLYBASE:FBgn0000057
chromosome : 2R
map location : 55B9-55B9|2-83.4 cM
description : adipose
type of gene : protein-coding
Symbol from nomenclature authority : adp
Full name from nomenclature authority : adipose
Nomenclature status : O
Other designations : CG5124-PA|CG5124-PB|adp-PA|adp-PB
Modification date : 2016-05-10
Symbol : poly NIH gene
LocusTag : Dmel_CG9829
Synonyms : 0081/31|CG9829|DmelCG9829|did|did/alt1|l(3)05137|l(3)S008131
dbXrefs : FLYBASE:FBgn0086371
chromosome : 3R
map location : 87E7-87E8
description : CG9829 gene product from transcript CG9829-RB
type of gene : protein-coding
Symbol from nomenclature authority : poly
Nomenclature status : O
Other designations : CG9829-PA|CG9829-PB|lethal (3) 05137|poly-PA|poly-PB
Modification date : 2016-05-10


Gene about :ribose
Pathway :Sc Salvage Pathways of Pyrimidine Ribonucleotides
Gene about :ADP
Pathway :Zm Vitamin B9 (folate) biosynthesis pathway



Transient Fiber Mats of Electrospun Poly(Propylene Carbonate) Composites with Remarkable Mechanical Strength.

Polymers with a triggered decomposition are attractive for an array of applications ranging from patterning to transient packaging materials as well as for environmental protection. This work showed for the first time UV and thermally triggered transience in fiber mats using poly(propylene carbonate) (PPC) composites. The electrospun PPC-composite fiber mats combine excellent decomposition performance (due to the high surface to volume ratio) with high stiffness and thus represent a new class of materials enabling innovative applications such as transient filter materials, short-time plant protection materials as well as temporary lightweight materials for aerospace engineering. Thermally and UV-triggerable additives (protected acids or base) have been used in different concentrations to tune the transience performance of the fiber mats over a wide range (75 - 212 °C). The addition of organo-modified clay (OMMT) enhanced mechanical stability and prevented shrinkage at room temperature. Different annealing methods have been used to improve the mechanical properties even further (tensile strength: 2 - 12 MPa, Young's modulus: 55 - 747 MPa) making these fiber mats attractive for a broad field of applications. An Ashby plot of Young's modulus versus degradation temperature for electrospun fiber mats is shown, revealing much lower degradation temperatures with higher moduli for PPC composites compared to other electrospun polymers. - Source :PubMed

Development of Silver Nanoparticles Decorated Emulsion-Templated Hierarchically Porous Poly(1-vinylimidazole) Beads for Water Treatment.

Water, the driver of nature, has always been polluted by the blind hurling of highly toxic contaminants, but human-friendly science continuously been presenting better avenues to help solve these challenging issues. In this connection, the present study introduces novel nanocomposites comprised of emulsion-templated hierarchically porous poly(1-vinylimidazole) beads loaded with the silver nanoparticles generated via an in-situ approach. These nanocomposites have been thoroughly characterized by FTIR, TGA, BET and FESEM. The appropriate surface chemistry, good thermal stability, swelling behavior, porosity, and nano-dimensions, contributed to achieve very good performance in water treatment. Keeping in view the decent adsorption capacity, easier handling and separation of the composite beads, these novel nanocomposites are highly efficient to remove arsenic and erichrome black T dye in addition to the inactivation and killing of Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive) bacteria. - Source :PubMed

A Design of Experiments (DoE) approach to identify the influencing parameters that determine poly-D,L-lactic acid (PDLLA) electrospun scaffold morphologies.

Electrospun fibrous materials have increasing applications in regenerative medicine due to the similarity of fibre constructs to the morphology of certain extracellular matrices. Although experimentally the electrospinning method is relatively simple, at the theoretical level the interactions between process parameters and their influence on the fibre morphology is not yet fully understood. Here, we hypothesised that a design of experiments (DoE) model could determine combinations of process parameters that result in significant effects on poly-D,L-lactic acid (PDLLA) fibre morphology. The process parameters used in this study were applied voltage, needle-to-collector distance, flow rate and polymer concentration. Data obtained for mean fibre diameter, standard deviation of the fibre diameter (stdev, measure of fibre morphology) and presence of 'beading' on the fibres (beads per µm2) were evaluated as a measure of PDLLA fibre morphology. Uniform fibres occurred at standard deviations of ≤ 500 nm, 'beads-on-string' morphologies were apparent between ± 500-1300 nm and large beads were observed at ± 1300-1800 nm respectively. Mean fibre diameter was significantly influenced by the applied voltage and interaction between flow rate and polymer concentration. Fibre morphology was mainly influenced by the polymer concentration, while bead distribution was significantly influenced by the polymer concentration as well as the flow rate. The resultant DoE model regression equations were tested and considered suitable for the prediction of parameters combinations needed for desired PDLLA fibre diameter and additionally provided information regarding the expected fibre morphology. - Source :PubMed

EXPRESS: Structural Changes in Poly(trimethylene adipate) and Poly(trimethylene succinate) During Melt Crystallization Studied by In-situ Infrared Spectroscopy.

- Source :PubMed

The penetration and phenotype modulation of smooth muscle cells on surface heparin modified Poly(ε-caprolactone) vascular scaffold.

The tubular porous poly(ε-caprolactone)(PCL) scaffold was fabricated by electrospinning. After then, the scaffold's surface was firstly eroded by hexyldiamine to endow amine group, and heparin was covalently grafted to the surface to get surface heparin modified scaffold(ShPCL scaffold). It was found that ShPCL scaffold can induce smooth muscle cells (SMCs) to penetrate the scaffold surface, while the SMCs can't penetrate the surface of PCL scaffold. Subsequently, the rabbit SMCs were seeded on the ShPCL scaffold and cultured for 14 days. It was found the expression of α-smooth muscle actin(α-SMA) in ShPCL scaffold maintained much higher level than that in culture plate, which implied the beginning of SMC differentiation in ShPCL scaffold. Furthermore, the immune-fluorescence staining of the cross-sections of ShPCL scaffold exhibited the expression of calponin in ShPCL scaffold can be detected after 7 and 14 days, whereas the expression of smooth muscle myosin heavy chain(SM-MHC) can also be detected at 14 days. These results proved that penetrated SMCs preferably differentiated in to contractile phenotype. The successful SMC penetration and the contractile phenotype implied ShPCL scaffold is a suitable candidate for regenerating smooth muscle layer in vascular tissue engineering. This article is protected by copyright. All rights reserved. - Source :PubMed

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