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Catalog number: genta-ABS0245
Product Quantity: 0.1 ml
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Gene target: sv40 t


Symbol : large NIH gene
chromosome : Un
description : like-glycosyltransferase
type of gene : protein-coding
Modification date : 2015-11-14

Related Pathways to: MOUSE ANTI SV40 LARGE T ANTIGEN

Gene about :antigen
Pathway :Rn Cytokines and Inflammatory Response (BioCarta)

Related product to: MOUSE ANTI SV40 LARGE T ANTIGEN

Related Articles about: MOUSE ANTI SV40 LARGE T ANTIGEN

Pre-polarization fields for earth's field NMR: Fast discharge for use with short T1 and large coils.

The sensitivity of earth's field NMR is greatly increased by the use of a pre-polarizing field Bp. When used with short T1 samples, the field must be decreased rapidly to avoid loss of the pre-polarized magnetization by relaxation. Such a rapid decrease in the field requires rapid discharge (∼10ms) of a large stored magnetic field energy (∼700J). In addition, in order that the full pre-polarized magnetization be available for the subsequent pulse sequence, the field discharge should be adiabatic. This requirement is difficult to fulfill in cases where Bp is not everywhere parallel to the earth's field, such as with a large surface coil. Circuitry for rapid and controlled discharge is presented. Simulations and experiments confirm the importance of both of these conditions. - Source :PubMed

Do large mergers increase or decrease the productivity of pharmaceutical R&D?

There is current uncertainty regarding the effects of mergers on pharmaceutical R&D productivity, with various mechanisms reported by which mergers could either help or harm R&D, and mixed empirical findings in prior analyses. Here, we present an analysis that is novel in several ways: we use downstream measures of R&D productivity, account for both inputs and outputs in our calculations, and use a self-controlled design. We find that recent large pharmaceutical mergers are associated with statistically significant increases in R&D productivity. These results are perhaps not surprising in light of the broader literature on R&D productivity that points to two factors as instrumental in driving higher R&D productivity (depth of scientific information, and objectivity of decision-making based on that information), both of which could be expected to increase because of a merger. - Source :PubMed

Fluctuating effects of genetic and plastic changes in body mass on population dynamics in a large herbivore.

Recent studies suggest that evolutionary changes can occur on a contemporary time scale. Hence, evolution can influence ecology and vice-versa. To understand the importance of eco-evolutionary dynamics in population dynamics, we must quantify the relative contribution of ecological and evolutionary changes to population growth and other ecological processes. To date, however, most eco-evolutionary dynamics studies have not partitioned the relative contribution of plastic and evolutionary changes in traits on population, community and ecosystem processes. Here, we quantify the effects of heritable and non-heritable changes in body mass distribution on survival, recruitment and population growth in wild bighorn sheep (Ovis canadensis) and compare their importance to the effects of changes in age structure, population density and weather. We applied a combination of a pedigree-based quantitative genetics model, statistical analyses on demography and a new statistical decomposition technique, the Geber method, to a long-term dataset of bighorn sheep on Ram Mountain (Canada), monitored individually from 1975 to 2012. We show three main results: (1) The relative importance of heritable change in mass, non-heritable change in mass, age structure, density and climate on population growth rate changed substantially over time. (2) An increase in body mass was accompanied by an increase in population growth through higher survival and recruitment rate. (3) Over the entire study period, changes in the body mass distribution of ewes, mostly through non-heritable changes, affected population growth to a similar extent as changes in age structure or in density. The importance of evolutionary changes was small compared to that of other drivers of changes in population growth but increased with time as evolutionary changes accumulated. Evolutionary changes became increasingly important for population growth as the length of the study period considered increased. Our results highlight the complex ways in which ecological and evolutionary changes can affect population dynamics and illustrate the large potential effect of trait changes on population processes. This article is protected by copyright. All rights reserved. - Source :PubMed

Tonic B-cell receptor signaling in diffuse large B-cell lymphoma.

We used CRISPR/Cas9-mediated genomic modification to investigate B-cell receptor (BCR) signaling in cell lines of diffuse large B-cell lymphoma (DLBCL). Three manipulations that altered BCR genes without affecting surface BCR levels showed that BCR signaling differs between the germinal center B-cell (GCB) subtype, which is insensitive to BTK inhibition by ibrutinib, and the activated B-cell (ABC) subtype. Replacing antigen-binding BCR regions had no effect on BCR signaling in GCB-DLBCL lines, reflecting this subtype's exclusive use of tonic BCR signaling. Conversely, Y188F mutation in the immunoreceptor tyrosine-based activation motif of CD79A inhibited tonic BCR signaling in GCB-DLBCL lines but did not affect their calcium flux after BCR crosslinking, or the proliferation of otherwise-unmodified ABC-DLBCL lines. CD79A-GFP fusion showed BCR clustering or diffuse distribution, respectively, in lines of ABC and GCB subtypes. Tonic BCR signaling acts principally to activate AKT, and forced activation of AKT rescued GCB-DLBCL lines from knockout of the BCR or two mediators of tonic BCR signaling, SYK and CD19. The magnitude and importance of tonic BCR signaling to proliferation and size of GCB-DLBCL lines, shown by the effect of BCR knockout, was highly variable; in contrast, pan-AKT knockout was uniformly toxic. This discrepancy was explained by finding that BCR knockout-induced changes in AKT activity (measured by gene expression, CXCR4 level, and a fluorescent reporter) correlated with changes in proliferation, and with baseline BCR surface density. PTEN protein expression and BCR surface density may influence clinical response to therapeutic inhibition of tonic BCR signaling in DLBCL. - Source :PubMed

A disconnect between disease activity and functional ability already in patients with early rheumatoid arthritis, depending on large joint involvement.

- Source :PubMed

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