MOUSE ANTI BOVINE MICROTUBULE ASSOCIATED PROTEIN TAU

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472 EUR
566 USD
391 GBP
known as: MOUSE ANTI BOVINE MICROTUBULE ASSOCIATED PROTEIN TAU
Catalog number: genta-ABS0243
Product Quantity: 0.1 ml
Category:
Supplier: AbD

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Gene target: microtubule associated protein tau

Related genes to: MOUSE ANTI BOVINE MICROTUBULE ASSOCIATED PROTEIN TAU

Symbol : Tau NIH gene
chromosome : Un
description : tau-like protein
type of gene : protein-coding
Modification date : 2015-11-14

Related Pathways to: MOUSE ANTI BOVINE MICROTUBULE ASSOCIATED PROTEIN TAU

Gene about :Microtubule
Pathway :Hs Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
Microtubule
Gene about :Tau
Pathway :Mm Alzheimers Disease
Tau
Gene about :PROTEIN
Pathway :Sc Protein Modifications
PROTEIN

Related product to: MOUSE ANTI BOVINE MICROTUBULE ASSOCIATED PROTEIN TAU

Related Articles about: MOUSE ANTI BOVINE MICROTUBULE ASSOCIATED PROTEIN TAU

Tau-Induced Ca(2+)/Calmodulin-Dependent Protein Kinase-IV Activation Aggravates Nuclear Tau Hyperphosphorylation.

Hyperphosphorylated tau is the major protein component of neurofibrillary tangles in the brains of patients with Alzheimer's disease (AD). However, the mechanism underlying tau hyperphosphorylation is not fully understood. Here, we demonstrated that exogenously expressed wild-type human tau40 was detectable in the phosphorylated form at multiple AD-associated sites in cytoplasmic and nuclear fractions from HEK293 cells. Among these sites, tau phosphorylated at Thr205 and Ser214 was almost exclusively found in the nuclear fraction at the conditions used in the present study. With the intracellular tau accumulation, the Ca(2+) concentration was significantly increased in both cytoplasmic and nuclear fractions. Further studies using site-specific mutagenesis and pharmacological treatment demonstrated that phosphorylation of tau at Thr205 increased nuclear Ca(2+) concentration with a simultaneous increase in the phosphorylation of Ca(2+)/calmodulin-dependent protein kinase IV (CaMKIV) at Ser196. On the other hand, phosphorylation of tau at Ser214 did not significantly change the nuclear Ca(2+)/CaMKIV signaling. Finally, expressing calmodulin-binding protein-4 that disrupts formation of the Ca(2+)/calmodulin complex abolished the okadaic acid-induced tau hyperphosphorylation in the nuclear fraction. We conclude that the intracellular accumulation of phosphorylated tau, as detected in the brains of AD patients, can trigger nuclear Ca(2+)/CaMKIV signaling, which in turn aggravates tau hyperphosphorylation. Our findings provide new insights for tauopathies: hyperphosphorylation of intracellular tau and an increased Ca(2+) concentration may induce a self-perpetuating harmful loop to promote neurodegeneration. - Source :PubMed

Book Review: Implementing the evidence-based practice (EBP) competencies in healthcare Melnyk B. Gallagher-Ford L. Fineout-Overholt E. Implementing the evidence-based practice (EBP) competencies in healthcare . Indianapolis, IN : Sigma Theta Tau International Honor Society of Nursing . 352 pp. $59.95 . ISBN: 978-1-940-44642-4 .

- Source :PubMed

Genome-wide association and interaction studies of CSF T-tau/Aβ42 ratio in ADNI cohort.

The pathogenic relevance in Alzheimer's disease (AD) presents a decrease of cerebrospinal fluid amyloid-ß42 (Aß42) burden and an increase in cerebrospinal fluid total tau (T-tau) levels. In this work, we performed genome-wide association study (GWAS) and genome-wide interaction study of T-tau/Aß42 ratio as an AD imaging quantitative trait on 843 subjects and 563,980 single-nucleotide polymorphisms (SNPs) in ADNI cohort. We aim to identify not only SNPs with significant main effects but also SNPs with interaction effects to help explain "missing heritability". Linear regression method was used to detect SNP-SNP interactions among SNPs with uncorrected p-value ≤0.01 from the GWAS. Age, gender, and diagnosis were considered as covariates in both studies. The GWAS results replicated the previously reported AD-related genes APOE, APOC1, and TOMM40, as well as identified 14 novel genes, which showed genome-wide statistical significance. Genome-wide interaction study revealed 7 pairs of SNPs meeting the cell-size criteria and with bonferroni-corrected p-value ≤0.05. As we expect, these interaction pairs all had marginal main effects but explained a relatively high-level variance of T-tau/Aß42, demonstrating their potential association with AD pathology. - Source :PubMed

A comparison of five partial volume correction methods for Tau and Amyloid PET imaging with [(18)F]THK5351 and [(11)C]PIB.

To suppress partial volume effect (PVE) in brain PET, there have been many algorithms proposed. However, each methodology has different property due to its assumption and algorithms. Our aim of this study was to investigate the difference among partial volume correction (PVC) method for tau and amyloid PET study. - Source :PubMed

A Pilot Longitudinal Study on Cerebrospinal Fluid (CSF) Tau Protein in Alzheimer's Disease and Vascular Dementia.

Alzheimer's disease (AD) has high a prevalence rate, high medical costs, and care difficulties, and has become a serious social and economic problem in our aging society. So far, there has not been a reliable and objective diagnostic criteria for AD found. In recent years, there have been many domestic and foreign studies on the biological markers of cerebrospinal fluid in the patients with AD, and high levels of the T-tau, P-tau found in cerebrospinal fluid (CSF) is at this point an indisputable fact. However, the relationship between these markers and the severity of dementia, as well as the development of the disease, should be further studied. - Source :PubMed

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