MONO_GOAT POLY CONJUGATE DILUENT

Price:
332 EUR
398 USD
275 GBP
known as: MONO_GOAT POLY CONJUGATE DILUENT
Catalog number: genta-ABS0011
Product Quantity: 100 ml
Category:
Supplier: AbD

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Gene target: mono poly conjugate diluent

Related genes to: MONO_GOAT POLY CONJUGATE DILUENT

Symbol : MONO NIH gene
dbXrefs : AnimalQTLdb:5493
chromosome : 11
map location : 11 0-33 cM
description : Monocyte number
type of gene : unknown
Other designations : Monocytes
Modification date : 2015-02-01
Symbol : poly NIH gene
LocusTag : Dmel_CG9829
Synonyms : 0081/31|CG9829|DmelCG9829|did|did/alt1|l(3)05137|l(3)S008131
dbXrefs : FLYBASE:FBgn0086371
chromosome : 3R
map location : 87E7-87E8
description : CG9829 gene product from transcript CG9829-RB
type of gene : protein-coding
Symbol from nomenclature authority : poly
Nomenclature status : O
Other designations : CG9829-PA|CG9829-PB|lethal (3) 05137|poly-PA|poly-PB
Modification date : 2016-05-10

Related Pathways to: MONO_GOAT POLY CONJUGATE DILUENT

Related product to: MONO_GOAT POLY CONJUGATE DILUENT

Related Articles about: MONO_GOAT POLY CONJUGATE DILUENT

Controlled Release from Aspirin based Linear Biodegradable Poly(anhydride esters) for Anti-inflammatory Activity.

This work reports the synthesis of a novel, aspirin-loaded, linear poly (anhydride ester) and provides mechanistic insights into the release of aspirin from this polymer for anti-inflammatory activity. As compared to conventional drug delivery systems that rely on diffusion based release, incorporation of bioactives in the polymer backbone is challenging and high loading is difficult to achieve. In the present study, we exploit the pentafunctional sugar alcohol (xylitol) to provide sites for drug (aspirin) attachment at its non-terminal OH groups. The terminal OH groups are polymerized with a diacid anhydride. The hydrolysis of the anhydride and ester bonds under physiological conditions release aspirin from the matrix. The resulting poly(anhydride ester) has high drug loading (53%) and displays controlled release kinetics of aspirin. The polymer releases 8.5 % and 20%, of the loaded drug in one and four weeks, respectively and has a release rate constant of 0.0035h(-0.61). The release rate is suitable for its use as an anti-inflammatory agent without being cytotoxic. The polymer exhibits good cytocompatibility and anti-inflammatory properties and may find applications as injectable or as an implantable bioactive material. The physical insights into the release mechanism may provide development of other drug loaded polymers. - Source :PubMed

Comparison study of exhaust plume impingement effects of small mono- and bipropellant thrusters using parallelized DSMC method.

A space propulsion system is important for the normal mission operations of a spacecraft by adjusting its attitude and maneuver. Generally, a mono- and a bipropellant thruster have been mainly used for low thrust liquid rocket engines. But as the plume gas expelled from these small thrusters diffuses freely in a vacuum space along all directions, unwanted effects due to the plume collision onto the spacecraft surfaces can dramatically cause a deterioration of the function and performance of a spacecraft. Thus, aim of the present study is to investigate and compare the major differences of the plume gas impingement effects quantitatively between the small mono- and bipropellant thrusters using the computational fluid dynamics (CFD). For an efficiency of the numerical calculations, the whole calculation domain is divided into two different flow regimes depending on the flow characteristics, and then Navier-Stokes equations and parallelized Direct Simulation Monte Carlo (DSMC) method are adopted for each flow regime. From the present analysis, thermal and mass influences of the plume gas impingements on the spacecraft were analyzed for the mono- and the bipropellant thrusters. As a result, it is concluded that a careful understanding on the plume impingement effects depending on the chemical characteristics of different propellants are necessary for the efficient design of the spacecraft. - Source :PubMed

Binding Differences of Two Homochiral [Ru(bpy)2dppz](2+) Complexes with poly(U)·poly(A)*poly(U) Triplex RNA.

The first investigation of chiral ruthenium(II) complexes Δ- and Λ-[Ru(bpy)2dppz](2+) and triplex RNA poly(U)·poly(A)*poly(U) was carried out, which showed that Δ enantiomer displayed significant ability in stabilizing model triplex RNA. - Source :PubMed

DNA Loading and Release Using Custom-Tailored Poly(L-lysine) Surfaces.

This manuscript describes the generation and study of surfaces modified with custom-crafted poly(L-lysine) (PLL) coatings for use in the loading and delivery of single-stranded DNA (ssDNA). The experimental strategy utilizes bidentate dithiol adsorbates to generate stably-bound azide-terminated self-assembled monolayers (SAMs) on gold possessing an oligo(ethylene glycol) (OEG) spacer. Consequent to the molecular assembly on gold, the azide termini are covalently attached to a maleimide linker moiety via a copper-catalyzed azide-alkyne "click" reaction. Functionalization with maleimide provides a platform for the subsequent attachment of cysteine-terminated poly(L-lysine) (PLL), thus forming a suitable surface for the loading of ssDNA via electrostatic interactions. In efforts to maximize DNA loading, we generate SAMs containing mixtures of short and long PLL segments and explore the DNA-loading capability of the various PLL SAMs. We then use thermal increases to trigger the release of the ssDNA from the surface. By examining the loading and release of ssDNA using these new two-dimensional systems, we gain preliminary insight into the potential efficacy of this approach when using three-dimensional gold nanostructure systems in future gene-delivery and biosensing applications. - Source :PubMed

Translation repression via modulation of the cytoplasmic poly(A)-binding protein in the inflammatory response.

Gene expression is precisely regulated during the inflammatory response to control infection and limit the detrimental effects of inflammation. Here, we profiled global mRNA translation dynamics in the mouse primary macrophage-mediated inflammatory response and identified hundreds of differentially translated mRNAs. These mRNAs' 3'UTRs have enriched binding motifs for several RNA-binding proteins, which implies extensive translational regulatory networks. We characterized one such protein, Zfp36, as a translation repressor. Using primary macrophages from a Zfp36-V5 epitope tagged knock-in mouse generated by CRISPR/Cas9-mediated genome editing, we found that the endogenous Zfp36 directly interacts with the cytoplasmic poly(A)-binding protein. Importantly, this interaction is required for the translational repression of Zfp36's target mRNAs in resolving inflammation. Altogether, these results uncovered critical roles of translational regulations in controlling appropriate gene expression during the inflammatory response and revealed a new biologically relevant molecular mechanism of translational repression via modulating the cytoplasmic poly(A)-binding protein. - Source :PubMed

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