Pathway: Rn Spinal Cord Injury WP2433 83002

1322Tnfsf13PdynNOCd47Plxna2Tnfsf13bNgfrLTB4Ltb4rPtprz1Cspg4Ltb1731243840Motor NeuronOligodendrocyteAstroctyeSpinal Cord InjuryTimePro-InflammatoryFactorsZfp36Fcgr2aPrb1PtpraIl1bZfp36Nos2TnfNr4a1Il4Btg2Btg2FBRCdk2Nos1Il2TnfIl6Tlr4FosIl1bTgfb1Tlr4TnfEgr1FosMmp12IfngGlial ScarAstrocyte GliosisSwelling/EdemaMbpAntigens ReleasedRtn4C5Cxcl1Neutrophil ChemoattractantsIL821, 34NeurtrophilsMonocytesAqp4TT32LegendTT:Therapeutic Target (increase)TTTTTT:Therapeutic Target (decrease)T-CellsB-CellsB Cell Stimulating33Activated Microglia/Macrophages(Transient)RepairIl1bNos2TnfArg1TOXIC FERROUSIRONFocal AdensionsEpha41, 16TTEfnb2TTTTTTTTCxcl10Neuro protectionAntibody ReleaseNeuronalInjuryResponseAstrocyteInjuryResponseG1-S Cell Cycle Re-entry (TT)37Ccng1MicrogliaMicrogliaActivationAxonal RetractionRecruitmentRecruitmentMmp9TT9Chondroitin Sulfate ProteoglycansNcan18Slit1Axon Retraction18Slit2Slit3Ntn1RgmaTTTTTTTTTTMmp99Mmp9Mmp999TTTTTTCcr2Il1r134TTECM BreakdownECM BreakdownIl1aCxcl1Monocyte ChemoattractantsCxcl221, 34Ccl2OligodendrocyteInjury ResponsePla2g6Pla2g5Pla2g2amelittinInflammationDemyelinationAnxa136TTTTTTTTRed Blood CellsMyelinEndothelial LeukocyteAdehsion FactorsIcam110SelpTTTTPlasticityKlk8TT4MicrogliaActivated Microglia/MacrophagesActivated Microglia/MacrophagesGfapTT9IntermediateFillament12Cdk4Tacr1E2f5Rb1PrkcaE2f1Mapk1Ccnd1MycGadd45aMapk3TTTTTTAstroctyeNeuron & OligodendrocyteApoptosis/NecrosisMicrogliaProliferationCasp3Tp53CytotoxicCytotoxicChst11VcanCol4a1Xylt1Col2a1AcanBcanGlial Scar FromationSox9Axonal GrowthInhibition12IgG, IgMTp5327TTTTTTGrin1Vim1939TTT Cell Stimulating33FK506Ppp3ca2TTFK5068FK5068Gap43TTFK506Axonal Regeneration8Fkbp1aIl2C3 ToxinC1Q and Fc receptive cellsMagRtn4RhoaRhocRhobRock2OmgRtn4rLilrb323MyelinInjury ResponseArachidonic acidPGH2PTGS27TT3ROSNox4Mir23bOlomoucine5Cdk1Gdnf30TTSema6a40TTAxonal GrowthInhibitionGja1ATP-Release15TTBdnfTTImmediate Response Genes37

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